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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation
DOI: 10.1016/j.neurobiolaging.2011.12.036
Abstract: Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. T...
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Petroula Proitsi,
Michelle K. Lupton,
Frank Dudbridge,
Magda Tsolaki,
Gillian Hamilton,
Makrina Daniilidou,
Megan Pritchard,
Kathryn Lord,
Belinda M. Martin,
David Craig,
Stephen Todd,
Bernadette McGuinness,
Paul Hollingworth,
Denise Harold,
Iwona Kloszewska,
Hilkka Soininen,
Patrizia Mecocci,
Bruno Velas,
Michael Gill,
Brian Lawlor,
David C. Rubinsztein,
Carol Brayne,
Peter A. Passmore,
Julie Williams,
Simon Lovestone,
John F. Powell
et al.
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Full-length article
(In Press Corrected Proof)
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03 February 2012 |
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Acute moderate exercise enhances compensatory brain activation in older adults
DOI: 10.1016/j.neurobiolaging.2011.12.022
Abstract: A growing number of reports state that regular exercise enhances brain function in older adults. Recently a functional near-infrared spectroscopy (fNIRS) study revealed that an acute bout of...
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Kazuki Hyodo,
Ippeita Dan,
Kazuya Suwabe,
Yasushi Kyutoku,
Yuhki Yamada,
Mitsuya Akahori,
Kyeongho Byun,
Morimasa Kato,
Hideaki Soya
et al.
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Full-length article
(In Press Corrected Proof)
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03 February 2012 |
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Expression pattern of oxidative stress and antioxidant defense-related genes in the aging Fischer 344/NHsd rat cochlea
DOI: 10.1016/j.neurobiolaging.2011.12.027
Abstract: The biological mechanisms that give rise to age-related hearing loss (ARHL) are still poorly understood. However, there is growing recognition that oxidative stress may be an important facto...
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Chiemi Tanaka,
Donald E. Coling,
Senthilvelan Manohar,
Guang-Di Chen,
Bo Hua Hu,
Richard Salvi,
Donald Henderson
et al.
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Full-length article
(In Press Corrected Proof)
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03 February 2012 |
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ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome
DOI: 10.1016/j.neurobiolaging.2011.12.035
Abstract: Mutations in ATP13A2 cause autosomal-recessive parkinsonism (Kufor-Rakeb syndrome; KRS). Because several other parkinsonism-associated proteins have been connected to mitochondrial function ...
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Anne Grünewald,
Björn Arns,
Philip Seibler,
Aleksandar Rakovic,
Alexander Münchau,
Alfredo Ramirez,
Carolyn M. Sue,
Christine Klein
et al.
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Full-length article
(In Press Corrected Proof)
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02 February 2012 |
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Behavioral decay in aging male C. elegans correlates with increased cell excitability
DOI: 10.1016/j.neurobiolaging.2011.12.016
Abstract: Deteriorative changes in behavioral functions are natural processes that accompany aging. In advanced aged C. elegans nematodes, gross decline in general behaviors, such as locomotion and fe...
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Xiaoyan Guo,
Andrew Navetta,
Daisy G. Gualberto,
L. Rene García
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Full-length article
(In Press Corrected Proof)
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30 January 2012 |
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Effect of plasma lipids, hypertension and APOE genotype on cognitive decline
DOI: 10.1016/j.neurobiolaging.2011.12.028
Abstract: We examined the combined effect of plasma lipids/hypertension and apolipoprotein E (APOE) genotype on cognitive function in elderly individuals. Plasma concentrations of high-density lipopro...
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Fumihiko Yasuno,
Satoshi Tanimukai,
Megumi Sasaki,
Chiaki Ikejima,
Fumio Yamashita,
Chiine Kodama,
Shin Hidaka,
Katsuyoshi Mizukami,
Takashi Asada
et al.
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Full-length article
(In Press Corrected Proof)
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30 January 2012 |
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Influence of functional connectivity and structural MRI measures on episodic memory
DOI: 10.1016/j.neurobiolaging.2011.12.029
Abstract: Age-related memory decline is the consequence of multiple biological factors that lead to brain structural and functional change, including gray matter atrophy, white matter injury, and loss...
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Jing He,
Owen Carmichael,
Evan Fletcher,
Baljeet Singh,
Ana-Maria Iosif,
Oliver Martinez,
Bruce Reed,
Andy Yonelinas,
Charles DeCarli
et al.
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Full-length article
(In Press Corrected Proof)
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30 January 2012 |
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PET imaging with [18F]AV-45 in an APP/PS1-21 murine model of amyloid plaque deposition
DOI: 10.1016/j.neurobiolaging.2011.12.024
Abstract: Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is characterized by the accumulation of β-amyloid peptide. In man, [18F]AV-45 with positron emission tomogra...
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Géraldine Poisnel,
Martine Dhilly,
Olivier Moustié,
Jérôme Delamare,
Ahmed Abbas,
Denis Guilloteau,
Louisa Barré
et al.
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory
DOI: 10.1016/j.neurobiolaging.2011.12.020
Abstract: One of the hot topics in Alzheimer's disease research field is the “amyloid hypothesis” postulating that the increase and deposition of beta-amyloid peptides (Aβ) is the main pathogenetic fa...
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Daniela Puzzo,
Lucia Privitera,
Agostino Palmeri
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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A simultaneous ERP/fMRI investigation of the P300 aging effect
DOI: 10.1016/j.neurobiolaging.2011.12.021
Abstract: One of the most reliable psychophysiological markers of aging is a linear decrease in the amplitude of the P300 potential, accompanied by a more frontal topographical orientation, but the pr...
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Redmond G. O'Connell,
Joshua H. Balsters,
Sophia M. Kilcullen,
William Campbell,
Arun W. Bokde,
Robert Lai,
Neil Upton,
Ian H. Robertson
et al.
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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Multiple inflammatory pathways are involved in the development and progression of cognitive deficits in APPswe/PS1dE9 mice
DOI: 10.1016/j.neurobiolaging.2011.12.023
Abstract: Increased accumulation of amyloid-beta peptide (Aβ) and neuroinflammation is known to exist within the Alzheimer's disease (AD) brain. However, it remains unclear which form of Aβ pathologie...
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Wei Zhang,
Miao Bai,
Ye Xi,
Jian Hao,
Zhuo Zhang,
Changjun Su,
Gesheng Lei,
Jianting Miao,
Zhuyi Li
et al.
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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Ventral and dorsal visual streams in posterior cortical atrophy: A DT MRI study
DOI: 10.1016/j.neurobiolaging.2011.12.025
Abstract: Using diffusion tensor magnetic resonance imaging tractography, ventral (inferior longitudinal fasciculus) and fronto-occipital (inferior fronto-occipital fasciculus) and dorsal (fronto-pari...
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Raffaella Migliaccio,
Federica Agosta,
Elisa Scola,
Giuseppe Magnani,
Stefano F. Cappa,
Elisabetta Pagani,
Elisa Canu,
Giancarlo Comi,
Andrea Falini,
Maria Luisa Gorno-Tempini,
Paolo Bartolomeo,
Massimo Filippi
et al.
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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Age-related changes to Na+ channel gating contribute to modified intrinsic neuronal excitability
DOI: 10.1016/j.neurobiolaging.2011.12.030
Abstract: Cognitive decline occurs during normal aging and is likely to be reflected in the neurophysiological properties of neural circuits with key roles in cognition, for example those of the limbi...
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Andrew D. Randall,
Clair Booth,
Jon T. Brown
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Short communication
(In Press Corrected Proof)
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27 January 2012 |
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Alterations in the histaminergic system in Alzheimer's disease: a postmortem study
DOI: 10.1016/j.neurobiolaging.2011.12.026
Abstract: Histamine is produced by the hypothalamic tuberomamillary nucleus (TMN). We studied its involvement in Alzheimer's disease (AD) by in situ hybridization of histidine decarboxylase (HDC), the...
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Ling Shan,
Koen Bossers,
Unga Unmehopa,
Ai-Min Bao,
Dick F. Swaab
et al.
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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Test sequence of CSF and MRI biomarkers for prediction of AD in subjects with MCI
DOI: 10.1016/j.neurobiolaging.2011.12.017
Abstract: Our aim was to identify the best diagnostic test sequence for predicting Alzheimer's disease (AD)-type dementia in subjects with mild cognitive impairment (MCI) using cerebrospinal fluid (CS...
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Stephanie Vos,
Ineke van Rossum,
Leah Burns,
Dirk Knol,
Philip Scheltens,
Hilkka Soininen,
Lars-Olof Wahlund,
Harald Hampel,
Magda Tsolaki,
Lennart Minthon,
Ron Handels,
Gilbert L'Italien,
Wiesje van der Flier,
Pauline Aalten,
Charlotte Teunissen,
Frederik Barkhof,
Kaj Blennow,
Robin Wolz,
Daniel Rueckert,
Frans Verhey,
Pieter Jelle Visser
et al.
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Full-length article
(In Press Corrected Proof)
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24 January 2012 |
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Toward a multifactorial model of Alzheimer disease
DOI: 10.1016/j.neurobiolaging.2011.11.029
Abstract: Relations among antecedent biomarkers of Alzheimer disease (AD) were evaluated using causal modeling; although correlation cannot be equated to causation, causation does require correlation....
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Martha Storandt,
Denise Head,
Anne M. Fagan,
David M. Holtzman,
John C. Morris
et al.
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Full-length article
(In Press Corrected Proof)
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20 January 2012 |
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Age-related differences in corticospinal excitability and inhibition during coordination of upper and lower limbs
DOI: 10.1016/j.neurobiolaging.2011.12.019
Abstract: The ability to coordinate upper and lower limbs—a prerequisite for many everyday activities—is known to decline with age. Here we report 2 experiments in which transcranial magnetic stimulat...
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Hakuei Fujiyama,
Mark R. Hinder,
Matthew W. Schmidt,
Michael I. Garry,
Jeffery J. Summers
et al.
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Full-length article
(In Press Corrected Proof)
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19 January 2012 |
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Body mass index is associated with biological CSF markers of core brain pathology in Alzheimer's disease
DOI: 10.1016/j.neurobiolaging.2011.12.012
demonstrate an association between lower body mass index (BMI) and positive Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in a cohort comprising individuals with AD, minimal cognitive...
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Ali Jawaid,
Henning Leske,
Manuela Neumann
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Correspondence
(In Press Corrected Proof)
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16 January 2012 |
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Quantitative EEG and LORETA: valuable tools in discerning FTD from AD?
DOI: 10.1016/j.neurobiolaging.2011.12.011
Abstract: Drawing a clinical distinction between frontotemporal dementia (FTD) and Alzheimer's disease (AD) is tricky, particularly at the early stages of disease. This study evaluates the possibility...
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Francesca Caso,
Marco Cursi,
Giuseppe Magnani,
Giovanna Fanelli,
Monica Falautano,
Giancarlo Comi,
Letizia Leocani,
Fabio Minicucci
et al.
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Whole brain N-acetylaspartate concentration is conserved throughout normal aging
DOI: 10.1016/j.neurobiolaging.2011.12.008
Abstract: We hypothesize that normal aging implies neuronal durability, reflected by age-independent concentrations of their marker—the amino acid derivative N-acetylaspartate (NAA). To test this, we ...
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William E. Wu,
Achim Gass,
Lidia Glodzik,
James S. Babb,
Jochen Hirsch,
Marc Sollberger,
Lutz Achtnichts,
Michael Amann,
Andreas U. Monsch,
Oded Gonen
et al.
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Sleep modulates word-pair learning but not motor sequence learning in healthy older adults
DOI: 10.1016/j.neurobiolaging.2011.06.029
Abstract: Sleep benefits memory across a range of tasks for young adults. However, remarkably little is known of the role of sleep on memory for healthy older adults. We used 2 tasks, 1 assaying motor...
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Jessica K. Wilson,
Bengi Baran,
Edward F. Pace-Schott,
Richard B. Ivry,
Rebecca M.C. Spencer
et al.
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Nuclear localization of Klotho in brain: an anti-aging protein
DOI: 10.1016/j.neurobiolaging.2011.12.018
Abstract: Klotho is a putative age-suppressing gene whose overexpression in mice results in extension of life span. The Klotho gene encodes a single-pass transmembrane protein whose extracellular doma...
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Dwight C. German,
Ida Khobahy,
Johanne Pastor,
Makoto Kuro-o,
Xinran Liu
et al.
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Short communication
(In Press Corrected Proof)
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16 January 2012 |
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Screening of the SOD1, FUS, TARDBP, ANG, and OPTN mutations in Korean patients with familial and sporadic ALS
DOI: 10.1016/j.neurobiolaging.2011.12.003
Abstract: About 5% of amyotrophic lateral sclerosis (ALS) cases are known to be familial (fALS) and mutations in SOD1 and other genes are found in more than 20% of fALS patients and in 2%–4% of appare...
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Min-Jung Kwon,
Wonki Baek,
Chang-Seok Ki,
Hyun Young Kim,
Seong-Ho Koh,
Jong-Won Kim,
Seung Hyun Kim
et al.
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Lipofuscin can be eliminated from the retinal pigment epithelium of monkeys
DOI: 10.1016/j.neurobiolaging.2011.12.009
Abstract: Lipofuscin is a cytologic hallmark of aging in metabolically active postmitotic cells including neurons, cardiac muscle cells, and the retinal pigment epithelium (RPE). High levels of lipofu...
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Sylvie Julien,
Ulrich Schraermeyer
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Development of large-scale functional networks over the lifespan
DOI: 10.1016/j.neurobiolaging.2011.11.031
Abstract: The development of large-scale functional organization of the human brain across the lifespan is not well understood. Here we used magnetoencephalographic recordings of 53 adults (ages 18–89...
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Winfried Schlee,
Vera Leirer,
Stephan Kolassa,
Franka Thurm,
Thomas Elbert,
Iris-Tatjana Kolassa
et al.
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Full-length article
(In Press Corrected Proof)
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12 January 2012 |
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Musical experience offsets age-related delays in neural timing
DOI: 10.1016/j.neurobiolaging.2011.12.015
Abstract: Aging disrupts neural timing, reducing the nervous system's ability to precisely encode sound. Given that the neural representation of temporal features is strengthened with musical training...
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Alexandra Parbery-Clark,
Samira Anderson,
Emily Hittner,
Nina Kraus
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Short communication
(In Press Corrected Proof)
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09 January 2012 |
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Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity
DOI: 10.1016/j.neurobiolaging.2011.12.006
Abstract: Parkinson's disease (PD) is a common neurodegenerative disorder of unknown pathogenesis characterized by the loss of nigrostriatal dopaminergic neurons. Oxidative stress, microglial activati...
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Peter Teismann,
Kinnari Sathe,
Angelika Bierhaus,
Lin Leng,
Heather L. Martin,
Richard Bucala,
Bernd Weigle,
Peter P. Nawroth,
Jörg B. Schulz
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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What predicts cognitive decline in de novo Parkinson's disease?
DOI: 10.1016/j.neurobiolaging.2011.11.028
Abstract: Subtle cognitive impairment can be detected in early Parkinson's disease (PD). In a consecutive series of de novo, drug-naive PD patients, we applied stepwise regression analysis to assess w...
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Dario Arnaldi,
Claudio Campus,
Michela Ferrara,
Francesco Famà,
Agnese Picco,
Fabrizio De Carli,
Jennifer Accardo,
Andrea Brugnolo,
Gianmario Sambuceti,
Silvia Morbelli,
Flavio Nobili
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Thirst deficits in aged rats are reversed by dietary omega-3 fatty acid supplementation
DOI: 10.1016/j.neurobiolaging.2011.12.001
Abstract: During heat waves many elderly individuals die as a consequence of dehydration. This is partially due to deficits in mechanisms controlling thirst. Reduced thirst following dipsogenic stimul...
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Denovan P. Begg,
Andrew J. Sinclair,
Richard S. Weisinger
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids
DOI: 10.1016/j.neurobiolaging.2011.11.025
Abstract: Glucocorticoids (GC)—corticosterone (CORT) in rodents and cortisol in primates—are stress-induced hormones secreted by adrenal glands that interact with the hypothalamic pituitary axis. High...
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Guang Qiu,
Edward L. Spangler,
Ruiqian Wan,
Marshall Miller,
Mark P. Mattson,
Kwok-Fai So,
Rafael de Cabo,
Sige Zou,
Donald K. Ingram
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice
DOI: 10.1016/j.neurobiolaging.2011.12.010
Abstract: Transgenic mice are used to model increased brain amyloid-β (Aβ) and amyloid plaque formation reflecting Alzheimer's disease pathology. In our study hippocampal network oscillations, populat...
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Liam Scott,
Jianlin Feng,
Tamás Kiss,
Elie Needle,
Kevin Atchison,
Thomas T. Kawabe,
Anthony J. Milici,
Éva Hajós-Korcsok,
David Riddell,
Mihály Hajós
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice
DOI: 10.1016/j.neurobiolaging.2011.12.013
Abstract: Methylation reactions linked to homocysteine in the one-carbon metabolism are increasingly elicited in Alzheimer's disease, although the association of hyperhomocysteinemia and of low B vita...
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Andrea Fuso,
Vincenzina Nicolia,
Laura Ricceri,
Rosaria A. Cavallaro,
Elisa Isopi,
Franco Mangia,
Maria Teresa Fiorenza,
Sigfrido Scarpa
et al.
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Full-length article
(In Press Corrected Proof)
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06 January 2012 |
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Tau acts as an independent genetic risk factor in pathologically proven PD
DOI: 10.1016/j.neurobiolaging.2011.11.001
Abstract: MAPT has been repeatedly linked with Parkinson's disease (PD) in association studies. Although tau deposition may be seen in PD, its relevance to the pathogenesis of the condition remains un...
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Gavin Charlesworth,
Sonia Gandhi,
Jose M. Bras,
Roger A. Barker,
David J. Burn,
Patrick F. Chinnery,
Stephen M. Gentleman,
Rita Guerreiro,
John Hardy,
Janice L. Holton,
Andrew Lees,
Karen Morrison,
Una-Marie Sheerin,
Nigel Williams,
Huw Morris,
Tamas Revesz,
Nicholas W. Wood
et al.
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Short communication
(In Press Corrected Proof)
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06 January 2012 |
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Genetic testing in familial and young-onset Alzheimer's disease: mutation spectrum in a Serbian cohort
DOI: 10.1016/j.neurobiolaging.2011.12.007
Abstract: Alzheimer's disease (AD) is the most common form of dementia. To date, more than 200 mutations in three genes have been identified as cause of early-onset autosomal dominant inherited AD. Th...
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Valerija Dobricic,
Elka Stefanova,
Milena Jankovic,
Nicole Gurunlian,
Ivana Novakovic,
John Hardy,
Vladimir Kostic,
Rita Guerreiro
et al.
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Short communication
(In Press Corrected Proof)
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06 January 2012 |
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Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury
DOI: 10.1016/j.neurobiolaging.2011.11.026
Abstract: Advancing age is a major risk factor for many neurodegenerative diseases but the underlying pathophysiology is not clear. We hypothesize that aging impairs the ability of neurons in the cent...
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Yu Xiang George Kong,
Nicole van Bergen,
Bang V. Bui,
Vicki Chrysostomou,
Algis J. Vingrys,
Ian A. Trounce,
Jonathan G. Crowston
et al.
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Full-length article
(In Press Corrected Proof)
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04 January 2012 |
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Vascular predictors of cognitive decline in patients with mild cognitive impairment
DOI: 10.1016/j.neurobiolaging.2011.11.027
Abstract: Our aim in this study was to assess the relationship between the state of cerebral vessels and the risk of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). We inc...
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Giovanna Viticchi,
Lorenzo Falsetti,
Fabrizio Vernieri,
Claudia Altamura,
Marco Bartolini,
Simona Luzzi,
Leandro Provinciali,
Mauro Silvestrini
et al.
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Full-length article
(In Press Corrected Proof)
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04 January 2012 |
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The early events of Alzheimer's disease pathology: from mitochondrial dysfunction to BDNF axonal transport deficits
DOI: 10.1016/j.neurobiolaging.2011.11.004
Abstract: Although there are numerous studies regarding Alzheimer's disease (AD), the cause and progression of AD are still not well understood. The researches in the past decade implicated amyloid-be...
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Xuan Ye,
Wenjiao Tai,
Dan Zhang
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Review article
(In Press Corrected Proof)
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04 January 2012 |
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Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function
DOI: 10.1016/j.neurobiolaging.2011.12.002
Abstract: Vitamin D3 plays a key role in immune regulation and may protect against the aging process. A focal point for age-related changes is the outer retina of the eye where there is high metabolic...
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Vivian Lee,
Elissa Rekhi,
Jaimie Hoh Kam,
Glen Jeffery
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Full-length article
(In Press Corrected Proof)
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04 January 2012 |
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Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease
DOI: 10.1016/j.neurobiolaging.2011.11.030
Abstract: Huntington's disease (HD) is associated with profound autonomic dysfunction including dysregulation of cardiovascular control often preceding cognitive or motor symptoms. Brain-derived neuro...
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Kathleen J. Griffioen,
Ruiqian Wan,
Tashalee R. Brown,
Eitan Okun,
Simonetta Camandola,
Mohamed R. Mughal,
Terry M. Phillips,
Mark P. Mattson
et al.
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Short communication
(In Press Corrected Proof)
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04 January 2012 |
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Age-associated learning and memory deficits in two mouse versions of the stone T-maze
DOI: 10.1016/j.neurobiolaging.2011.12.004
Abstract: We have previously reported that a modified Stone T-maze (STM), using escape from water as motivation, was effective in evaluating learning and memory ability in young C57/BL6 mice. Here we ...
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Paul J. Pistell,
Edward L. Spangler,
Bennett Kelly-Bell,
Marshall G. Miller,
Rafael de Cabo,
Donald K. Ingram
et al.
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Full-length article
(In Press Corrected Proof)
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04 January 2012 |
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Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex
DOI: 10.1016/j.neurobiolaging.2011.12.005
Abstract: Complement plays a vital role in both the innate and adaptive immune systems. It recognizes a target, opsonizes it, generates anaphylatoxins, and directly kills cells through the membrane at...
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Moonhee Lee,
Jian-Ping Guo,
Claudia Schwab,
Edith G. McGeer,
Patrick L. McGeer
et al.
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Full-length article
(In Press Corrected Proof)
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04 January 2012 |
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Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice
DOI: 10.1016/j.neurobiolaging.2011.11.006
Abstract: Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity, learning, and memory. Levels of BDNF and its main receptor TrkB (TrkB.TK) have been reported to be de...
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Susanna Kemppainen,
Tomi Rantamäki,
André Jerónimo-Santos,
Gregoire Lavasseur,
Henri Autio,
Nina Karpova,
Elisa Kärkkäinen,
Saara Stavén,
Hugo Vicente Miranda,
Tiago F. Outeiro,
Maria J. Diógenes,
Serge Laroche,
Sabrina Davis,
Ana M. Sebastião,
Eero Castrén,
Heikki Tanila
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Synaptic protein deficits are associated with dementia irrespective of extreme old age
DOI: 10.1016/j.neurobiolaging.2011.08.017
Abstract: Recent evidence shows that despite high incidence of dementia in the very old, they exhibit significantly lower levels of Alzheimer's disease (AD) neuropathology relative to younger persons ...
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Michal Schnaider Beeri,
Vahram Haroutunian,
James Schmeidler,
Mary Sano,
Peter Fam,
Aaron Kavanaugh,
Alasdair M. Barr,
William G. Honer,
Pavel Katsel
et al.
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Full-length article
(In Press Corrected Proof)
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29 December 2011 |
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Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults
DOI: 10.1016/j.neurobiolaging.2011.11.013
Abstract: The epsilon4 allele of the apolipoprotein E gene (ApoE), as well as aging increase the risk of Alzheimer's and vascular diseases. Electroencephalogram (EEG) reactivity to hyperventilation (H...
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Natalya V. Ponomareva,
Andrey Y. Goltsov,
Svetlana S. Kunijeva,
Nadejda S. Scheglova,
Daria D. Malina,
Andrey A. Mitrofanov,
Tatiana I. Boikova,
Evgeny I. Rogaev
et al.
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Full-length article
(In Press Corrected Proof)
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29 December 2011 |
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Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice
DOI: 10.1016/j.neurobiolaging.2011.11.023
Abstract: We report that neuronal overexpression of the endogenous inhibitor of calpains, calpastatin (CAST), in a mouse model of human Alzheimer's disease (AD) β-amyloidosis, the APP23 mouse, reduces...
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Jose Morales-Corraliza,
Jason D. Berger,
Matthew J. Mazzella,
Veeranna,
Thomas A. Neubert,
Jorge Ghiso,
Mala V. Rao,
Matthias Staufenbiel,
Ralph A. Nixon,
Paul M. Mathews
et al.
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Full-length article
(In Press Corrected Proof)
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29 December 2011 |
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A new neuronal target for beta-amyloid peptide in the rat hippocampus
DOI: 10.1016/j.neurobiolaging.2011.11.024
Abstract: In Alzheimer's disease, amyloid beta peptide (Aβ) accumulation is associated with hippocampal network dysfunction. Intrahippocampal injections of Aβ induce aberrant inhibitory septohippocamp...
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Vincent Villette,
Frédérique Poindessous-Jazat,
Brice Bellessort,
Elodie Roullot,
Yvan Peterschmitt,
Jacques Epelbaum,
Aline Stéphan,
Patrick Dutar
et al.
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Full-length article
(In Press Corrected Proof)
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29 December 2011 |
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Mutation analysis of VCP in familial and sporadic amyotrophic lateral sclerosis
DOI: 10.1016/j.neurobiolaging.2011.11.022
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive loss of motor neurons in the motor cortex, brain stem and spinal cord. Mutations in...
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Kelly L. Williams,
Jennifer A. Solski,
Garth A. Nicholson,
Ian P. Blair
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Full-length article
(In Press Corrected Proof)
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26 December 2011 |
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Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice
DOI: 10.1016/j.neurobiolaging.2011.10.028
Abstract: The pathogenesis of Alzheimer's disease (AD) is tightly associated with metabolic dysfunctions. In particular, a potential link between type 2 diabetes (T2DM) and AD has been suggested epide...
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Masato Maesako,
Kengo Uemura,
Masakazu Kubota,
Akira Kuzuya,
Kazuki Sasaki,
Megumi Asada,
Kiwamu Watanabe,
Naoko Hayashida,
Masafumi Ihara,
Hidefumi Ito,
Shun Shimohama,
Takeshi Kihara,
Ayae Kinoshita
et al.
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Full-length article
(In Press Corrected Proof)
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26 December 2011 |
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A review of the structural alterations in the cerebral hemispheres of the aging rhesus monkey
DOI: 10.1016/j.neurobiolaging.2011.11.015
Abstract: Like humans, rhesus monkeys show cognitive decline and this review considers what structural age-related changes underlie this decline. Some structural measures do not alter significantly wi...
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Alan Peters,
Thomas Kemper
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Review article
(In Press Corrected Proof)
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23 December 2011 |
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Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects
DOI: 10.1016/j.neurobiolaging.2011.11.020
Abstract: Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively nor...
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Miharu Samuraki,
Ichiro Matsunari,
Wei-Ping Chen,
Keisuke Shima,
Daisuke Yanase,
Nozomi Takeda,
Hiroshi Matsuda,
Masahito Yamada
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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Parasympathetic autonomic dysfunction is common in mild cognitive impairment
DOI: 10.1016/j.neurobiolaging.2011.11.017
Abstract: Components of the central autonomic network attract the greatest neurofibrillary degeneration and related cell death during the course of Alzheimer's disease (AD). The insular cortex and bra...
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Orla Collins,
Shiela Dillon,
Ciaran Finucane,
Brian Lawlor,
Rose Anne Kenny
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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Lack of association between prior depressive episodes and cerebral [11C]PiB binding
DOI: 10.1016/j.neurobiolaging.2011.11.021
Abstract: Depressive symptoms are frequent in Alzheimer's disease (AD), but it is controversial whether depression is a risk factor for AD. This study measured for the first time cortical amyloid-β (A...
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Karine Madsen,
Bo J. Hasselbalch,
Kristian S. Frederiksen,
Mette E. Haahr,
Anders Gade,
Ian Law,
Julie C. Price,
Gitte M. Knudsen,
Lars V. Kessing,
Steen G. Hasselbalch
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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Tocopherols and tocotrienols plasma levels are associated with cognitive impairment
DOI: 10.1016/j.neurobiolaging.2011.11.019
Abstract: Vitamin E includes 8 natural compounds (4 tocopherols, 4 tocotrienols) with potential neuroprotective activity. α-Tocopherol has mainly been investigated in relation to cognitive impairment....
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Francesca Mangialasche,
Weili Xu,
Miia Kivipelto,
Emanuela Costanzi,
Sara Ercolani,
Martina Pigliautile,
Roberta Cecchetti,
Mauro Baglioni,
Andrew Simmons,
Hilkka Soininen,
Magda Tsolaki,
Iwona Kloszewska,
Bruno Vellas,
Simon Lovestone,
Patrizia Mecocci,
AddNeuroMed Consortium
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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Critical role of cPLA2 in Aβ oligomer-induced neurodegeneration and memory deficit
DOI: 10.1016/j.neurobiolaging.2011.11.008
Abstract: Soluble beta-amyloid (Aβ) oligomers are considered to putatively play a critical role in the early synapse loss and cognitive impairment observed in Alzheimer's disease. We previously demons...
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Cédric Desbène,
Catherine Malaplate-Armand,
Ihsen Youssef,
Pierre Garcia,
Christophe Stenger,
Mathilde Sauvée,
Nicolas Fischer,
Dorine Rimet,
Violette Koziel,
Marie-Christine Escanyé,
Thierry Oster,
Badreddine Kriem,
Frances T. Yen,
Thierry Pillot,
Jean Luc Olivier
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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Differential relationships between transcallosal structural and functional connectivity in young and older adults
DOI: 10.1016/j.neurobiolaging.2011.11.018
Abstract: Numerous studies have identified age differences in brain structure and function that correlate with declines in motor performance. While these investigations have typically focused on activ...
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Brett W. Fling,
Youngbin Kwak,
Scott J. Peltier,
Rachael D. Seidler
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Short communication
(In Press Corrected Proof)
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19 December 2011 |
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Centrosomal aggregates and Golgi fragmentation disrupt vesicular trafficking of DAT
DOI: 10.1016/j.neurobiolaging.2011.11.014
Abstract: Lewy bodies containing the centrosomal protein γ-tubulin and fragmentation of Golgi apparatus (GA) have been described in nigral neurons of Parkinson's disease (PD) patients. However, the re...
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Francisco J. Diaz-Corrales,
Ikuko Miyazaki,
Masato Asanuma,
Diego Ruano,
Rosa M. Rios
et al.
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Full-length article
(In Press Corrected Proof)
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19 December 2011 |
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Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse
DOI: 10.1016/j.neurobiolaging.2011.11.016
Abstract: Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease with no specific treatment at present. Several healthy lifestyle options and over-the-counter drugs that it ha...
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Yoelvis García-Mesa,
Lydia Giménez-Llort,
Luis C. López,
Carmen Venegas,
Rosa Cristòfol,
Germain Escames,
Darío Acuña-Castroviejo,
Coral Sanfeliu
et al.
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Full-length article
(In Press Corrected Proof)
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19 December 2011 |
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Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation
DOI: 10.1016/j.neurobiolaging.2011.11.003
Abstract: Understanding the molecular sequence of events that culminate in multiple abnormalities in brains from patients that died with Alzheimer's disease (AD) will help to reveal the mechanisms of ...
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Gary E. Gibson,
Huan-Lian Chen,
Hui Xu,
Linghua Qiu,
Zuoshang Xu,
Travis T. Denton,
Qingli Shi
et al.
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Full-length article
(In Press Corrected Proof)
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15 December 2011 |
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Autophagic degradation of tau in primary neurons and its enhancement by trehalose
DOI: 10.1016/j.neurobiolaging.2011.11.009
Abstract: Modulating the tau level may represent a therapeutic target for Alzheimer's disease (AD), as accumulating evidence shows that Abeta-induced neurodegeneration is mediated by tau. It is theref...
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Ulrike Krüger,
Yipeng Wang,
Satish Kumar,
Eva-Maria Mandelkow
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Full-length article
(In Press Corrected Proof)
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15 December 2011 |
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GABAB receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats
DOI: 10.1016/j.neurobiolaging.2011.11.011
Abstract: Gamma aminobutyric acid (GABA)B receptors (GABABRs) have been linked to a wide range of physiological and cognitive processes and are of interest for treating a number of neurodegenerative a...
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Joseph A. McQuail,
Cristina Bañuelos,
Candi L. LaSarge,
Michelle M. Nicolle,
Jennifer L. Bizon
et al.
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Full-length article
(In Press Corrected Proof)
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15 December 2011 |