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Editorial Advisory Board
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IFC
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| Regular Papers |
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The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE
01 July 2010
Abstract: Alzheimer's disease (AD) is a complex disorder with a clear genetic component. Three genes have been identified as the cause of early onset familial AD (EOAD). The most common form of the di...
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Rita J. Guerreiro,
Deborah R. Gustafson,
John Hardy
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437-456
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Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease
07 June 2010
Abstract: Replications of the association between APOE-ε4 allele load and regional brain atrophy in Alzheimer's disease (AD) patients hold promise for future studies testing relationships between othe...
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Becky Inkster,
Anil W. Rao,
Khanum Ridler,
Nicola Filippini,
Brandon Whitcher,
Thomas E. Nichols,
Sally Wetten,
Rachel A. Gibson,
Michael Borrie,
Andrew Kertesz,
Danilo A. Guzman,
Inge Loy-English,
Julie Williams,
Philipp G. Saemann,
Dorothee P. Auer,
Florian Holsboer,
Federica Tozzi,
Pierandrea Muglia,
Emilio Merlo-Pich,
Paul M. Matthews
et al.
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457-465
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Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease
14 June 2010
Abstract: Functional magnetic resonance imaging (fMRI) of default mode network (DMN) brain activity during resting is recently gaining attention as a potential noninvasive biomarker to diagnose incipi...
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Walter Koch,
Stephan Teipel,
Sophia Mueller,
Jens Benninghoff,
Maxmilian Wagner,
Arun L.W. Bokde,
Harald Hampel,
Ute Coates,
Maximilian Reiser,
Thomas Meindl
et al.
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466-478
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Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study
31 May 2010
Abstract: In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT2A) receptors. To establish if this was d...
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Lisbeth Marner,
Vibe G. Frokjaer,
Jan Kalbitzer,
Szabolcs Lehel,
Karine Madsen,
William F.C. Baaré,
Gitte M. Knudsen,
Steen G. Hasselbalch
et al.
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479-487
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Microstructural changes and atrophy in brain white matter tracts with aging
01 July 2010
Abstract: Diffusion tensor (DT) magnetic resonance imaging (MRI) tractography was used to investigate microstructural and volumetric abnormalities of the major brain white matter (WM) tracts with agin...
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Stefania Sala,
Federica Agosta,
Elisabetta Pagani,
Massimiliano Copetti,
Giancarlo Comi,
Massimo Filippi
et al.
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488-498.e2
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Amyloid β1–42 oligomer inhibits myelin sheet formation in vitro
01 July 2010
Abstract: Accumulating evidence indicates that white matter degeneration contributes to the neural disconnections that underlie Alzheimer's disease pathophysiology. Although this white matter degenera...
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Makoto Horiuchi,
Izumi Maezawa,
Aki Itoh,
Kouji Wakayama,
Lee-Way Jin,
Takayuki Itoh,
Charles DeCarli
et al.
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499-509
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Brain iron deposits are associated with general cognitive ability and cognitive aging
09 June 2010
Abstract: A novel analysis of magnetic resonance imaging (MRI) scans based on multispectral image fusion was used to quantify iron deposits in basal ganglia and microbleeds in 143 nondemented subjects...
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Lars Penke,
Maria C. Valdés Hernandéz,
Susana Muñoz Maniega,
Alan J. Gow,
Catherine Murray,
John M. Starr,
Mark E. Bastin,
Ian J. Deary,
Joanna M. Wardlaw
et al.
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510-517.e2
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| Brief Communication |
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Association of CLU and PICALM variants with Alzheimer's disease
07 June 2010
Abstract: Two recent large genome-wide association studies have reported significant associations in the CLU (APOJ), CR1, and PICALM genes with the risk of Alzheimer’s disease (AD). In order to replic...
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M. Ilyas Kamboh,
Ryan L. Minster,
F. Yesim Demirci,
Mary Ganguli,
Steven T. DeKosky,
Oscar L. Lopez,
M. Michael Barmada
et al.
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518-521
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| Regular Papers |
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MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice
12 July 2010
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder mainly characterized by amyloid-beta (Aβ) deposition and neurofibrillary tangles (NFTs). The abnormal enrichment of amylo...
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Wei Liu,
Chang Liu,
Jingxi Zhu,
Pengcheng Shu,
Bin Yin,
Yanhua Gong,
Boqin Qiang,
Jiangang Yuan,
Xiaozhong Peng
et al.
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522-534
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Protein oxidation inhibits NO-mediated signaling pathway for synaptic plasticity
28 June 2010
Abstract: Oxidative stress is a primary factor inducing brain dysfunction in aged animals. However, how oxidation affects brain function is not fully understood. Here we show that oxidation inhibits s...
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Sho Kakizawa,
Masahiko Shibazaki,
Nozomu Mori
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535-545
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BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog
07 May 2010
Abstract: The aged canine (dog) is an excellent model for investigating the neurobiological changes that underlie cognitive impairment and neurodegeneration in humans, as canines and humans undergo si...
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Margaret Fahnestock,
Monica Marchese,
Elizabeth Head,
Viorela Pop,
Bernadeta Michalski,
William N. Milgram,
Carl W. Cotman
et al.
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546-554
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Object recognition memory and BDNF expression are reduced in young TgCRND8 mice
07 May 2010
Abstract: The TgCRND8 mouse model of Alzheimer's disease exhibits progressive cortical and hippocampal β-amyloid accumulation, resulting in plaque pathology and spatial memory impairment by 3 months o...
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Beverly M. Francis,
John Kim,
Meredith E. Barakat,
Stephan Fraenkl,
Yeni H. Yücel,
Shiyong Peng,
Bernadeta Michalski,
Margaret Fahnestock,
JoAnne McLaurin,
Howard T.J. Mount
et al.
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555-563
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| Brief Communication |
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Age-related changes in the Bengalese finch song motor program
07 June 2010
Abstract: It is well established that there are remarkable similarities between song learning in oscine birds and acquisition of speech in young children. Human speech shows marked changes with senesc...
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Brenton G. Cooper,
Jorge M. Méndez,
Sigal Saar,
Addison G. Whetstone,
Ron Meyers,
Franz Goller
et al.
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564-568
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| Regular Papers |
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Lactate dyscrasia: a novel explanation for amyotrophic lateral sclerosis
14 June 2010
Abstract: Amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) is a progressive debilitating neurodegenerative disease with no cure. We propose a novel molecular model for the pathogenesis of ALS...
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Sivan Vadakkadath Meethal,
Craig S. Atwood
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569-581
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Cognitive performance in older males is associated with growth hormone secretion
20 May 2010
Abstract: Decreases in GH secretion with age may contribute to cognitive changes associated with aging. We evaluated the relation between GH secretion and cognition in elderly males by assessing corre...
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E.H. Quik,
E.B. Conemans,
G.D. Valk,
J.L. Kenemans,
H.P.F. Koppeschaar,
P.S. van Dam
et al.
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582-587
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Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation
17 May 2010
Abstract: Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) have a potential therapeutic role in the treatment of neurological disorders, but their current clinical usage and mechan...
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Hyun Ju Lee,
Jong Kil Lee,
Hyun Lee,
Janet E. Carter,
Jong Wook Chang,
Wonil Oh,
Yoon Sun Yang,
Jun-Gyo Suh,
Byoung-Hee Lee,
Hee Kyung Jin,
Jae-sung Bae
et al.
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588-602
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Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium
14 May 2010
Abstract: Delirium is an acute, severe neuropsychiatric syndrome, characterized by cognitive deficits, that is highly prevalent in aging and dementia and is frequently precipitated by peripheral infec...
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Carol Murray,
David J. Sanderson,
Chris Barkus,
Robert M.J. Deacon,
J. Nicholas P. Rawlins,
David M. Bannerman,
Colm Cunningham
et al.
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603-616.e3
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| Abstracts of Online Articles |
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Normal age-related brain morphometric changes: nonuniformity across cortical thickness, surface area and gray matter volume?
26 August 2010
Abstract: Normal aging is accompanied by global as well as regional structural changes. While these age-related changes in gray matter volume have been extensively studied, less has been done using ne...
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Herve Lemaitre,
Aaron L. Goldman,
Fabio Sambataro,
Beth A. Verchinski,
Andreas Meyer-Lindenberg,
Daniel R. Weinberger,
Venkata S. Mattay
et al.
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617.e1-617.e9
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Hormone levels and cognitive function in postmenopausal midlife women
04 October 2010
Abstract: Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women's Midlife Health Project cohort were administered a comprehensive batt...
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Joanne Ryan,
Frank Z. Stanczyk,
Lorraine Dennerstein,
Wendy J. Mack,
Margaret S. Clark,
Cassandra Szoeke,
Daniel Kildea,
Victor W. Henderson
et al.
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617.e11-617.e22
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The effects of APOE on brain activity do not simply reflect the risk of Alzheimer's disease
13 January 2011
Abstract: Possession of the APOE-ε4 allele is the best established genetic risk factor for sporadic Alzheimer's disease (AD), while the ε2 allele may confer protection against the disease. Previous fu...
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Aaron J. Trachtenberg,
Nicola Filippini,
Jane Cheeseman,
Eugene P. Duff,
Matt J. Neville,
Klaus P. Ebmeier,
Fredrik Karpe,
Clare E. Mackay
et al.
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618.e1-618.e13
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Dynamin binding protein gene expression and memory performance in aged rats
13 January 2011
Abstract: Previous studies have shown that messenger RNA (mRNA) of the dynamin-binding protein (DNMBP), a scaffold protein regulating actin cytoskeleton and synaptic vesicle pools, is lower in neuropa...
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Tiziana Casoli,
Giuseppina Di Stefano,
Patrizia Fattoretti,
Belinda Giorgetti,
Marta Balietti,
Fabrizia Lattanzio,
Giorgio Aicardi,
Daniela Platano
et al.
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618.e15-618.e19
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Ethanol withdrawal hastens the aging of cytochrome c oxidase
25 March 2011
Abstract: We investigated whether abrupt ethanol withdrawal (EW) age-specifically inhibits a key mitochondrial enzyme, cytochrome c oxidase (COX), and whether estrogen mitigates this problem. We also ...
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Marianna E. Jung,
Xiaohua Ju,
Daniel B. Metzger,
James W. Simpkins
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618.e21-618.e32
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Cognitive function in families with exceptional survival
25 March 2011
Abstract: The authors investigated whether cognitive function may be used as an endophenotype for longevity by assessing the cognitive performance of a family-based cohort consisting of 1380 individua...
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Sandra Barral,
Stephanie Cosentino,
Rosann Costa,
Amy Matteini,
Kaare Christensen,
Stacy L. Andersen,
Nancy W. Glynn,
Anne B. Newman,
Richard Mayeux
et al.
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619.e1-619.e7
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Recovery from ischemia in the middle-aged brain: a nonhuman primate model
04 April 2011
Abstract: Studies of recovery from stroke mainly utilize rodent models and focus primarily on young subjects despite the increased prevalence of stroke with age and the fact that recovery of function ...
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Tara L. Moore,
Ronald J. Killiany,
Monica A. Pessina,
Mark B. Moss,
Seth P. Finklestein,
Douglas L. Rosene
et al.
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619.e9-619.e24
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Truncated tau and Aβ cooperatively impair mitochondria in primary neurons
31 March 2011
Abstract: Mitochondrial dysfunction is likely a significant contributing factor to Alzheimer disease pathogenesis, and both amyloid peptide (Aβ) and pathological forms of tau may contribute to this im...
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Rodrigo A. Quintanilla,
Philip J. Dolan,
Youngnam N. Jin,
Gail V.W. Johnson
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619.e25-619.e35
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Regional changes in type 1 cannabinoid receptor availability in Parkinson's disease in vivo
04 April 2011
Abstract: The type 1 cannabinoid receptor (CB1) is a crucial modulator of synaptic transmission in brain and has been proposed as a potential therapeutic target in Parkinson's disease (PD), especially...
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Koen Van Laere,
Cindy Casteels,
Sophie Lunskens,
Karolien Goffin,
Igor D. Grachev,
Guy Bormans,
Wim Vandenberghe
et al.
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620.e1-620.e8
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Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood
18 April 2011
Abstract: It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrate...
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Martin Lövdén,
Sabine Schaefer,
Hannes Noack,
Nils Christian Bodammer,
Simone Kühn,
Hans-Jochen Heinze,
Emrah Düzel,
Lars Bäckman,
Ulman Lindenberger
et al.
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620.e9-620.e22
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Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse
14 April 2011
Abstract: Tauopathies are characterized by hyperphosphorylation of the microtubule-associated protein tau and its accumulation into fibrillar aggregates. Toxic effects of aggregated tau and/or dysfunc...
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Jonathan Gilley,
Anjan Seereeram,
Kunie Ando,
Suzanne Mosely,
Simon Andrews,
Martin Kerschensteiner,
Thomas Misgeld,
Jean-Pierre Brion,
Brian Anderton,
Diane P. Hanger,
Michael P. Coleman
et al.
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621.e1-621.e15
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Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons
13 April 2011
Abstract: In Huntington's disease (HD), mutated huntingtin (mhtt) causes striatal neurodegeneration which is paralleled by elevated microglia cell numbers. In vitro corticostriatal slice and primary n...
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Andrew D. Kraft,
Linda S. Kaltenbach,
Donald C. Lo,
G. Jean Harry
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621.e17-621.e33
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Preclinical AD Workgroup staging: pathological correlates and potential challenges
21 April 2011
Abstract: The National Institute on Aging Preclinical Alzheimer's disease Workgroup (PADW) has issued a preliminary report with recommendations for classifying preclinical Alzheimer's disease (pAD) ac...
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Gregory A. Jicha,
Erin L. Abner,
Frederick A. Schmitt,
Richard J. Kryscio,
Kathryn P. Riley,
Gregory E. Cooper,
Nancy Stiles,
Marta S. Mendiondo,
Charles D. Smith,
Linda J. Van Eldik,
Peter T. Nelson
et al.
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622.e1-622.e16
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The role of extracerebral cholesterol homeostasis and ApoE e4 in cognitive decline
13 April 2011
Abstract: We examined the associations between extracerebral markers of cholesterol homeostasis and cognitive decline over 6 years of follow-up, and studied the modifying effect of apolipoprotein E (A...
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Tessa N. van den Kommer,
Miranda G. Dik,
Hannie C. Comijs,
Dieter Lütjohann,
Paul Lips,
Cees Jonker,
Dorly J.H. Deeg
et al.
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622.e17-622.e28
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Measuring the impact of exercise on cognitive aging: methodological issues
25 April 2011
Abstract: Physical exercise and fitness have been proposed as potential factors that promote healthy cognitive aging. Support for this hypothesis has come from cross sectional, longitudinal, and inter...
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Delyana I. Miller,
Vanessa Taler,
Patrick S.R. Davidson,
Claude Messier
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622.e29-622.e43
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Local brain atrophy accounts for functional activity differences in normal aging
25 April 2011
Abstract: Functional brain imaging studies of normal aging typically show age-related under- and overactivations during episodic memory tasks. Older individuals also undergo nonuniform gray matter vol...
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Grégoria Kalpouzos,
Jonas Persson,
Lars Nyberg
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623.e1-623.e13
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Dopamine and frontostriatal networks in cognitive aging
22 April 2011
Abstract: Recent studies have linked dopamine to differences in behavior and brain activity in normal individuals. We explored these relationships in older and younger adults by investigating how func...
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Ellen C. Klostermann,
Meredith N. Braskie,
Susan M. Landau,
James P. O'Neil,
William J. Jagust
et al.
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623.e15-623.e24
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Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease
25 April 2011
Abstract: Cognitively normal (NL) individuals with a maternal history of late-onset Alzheimer's disease (MH) show reduced brain glucose metabolism on FDG-PET as compared to those with a paternal histo...
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Lisa Mosconi,
Wai Tsui,
John Murray,
Pauline McHugh,
Yi Li,
Schantel Williams,
Elizabeth Pirraglia,
Lidia Glodzik,
Susan De Santi,
Shankar Vallabhajosula,
Mony J. de Leon
et al.
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624.e1-624.e9
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A potential role for the PD1/PD-L1 pathway in the neuroinflammation of Alzheimer's disease
25 April 2011
Abstract: The interaction between PD1 on T lymphocytes and PD-L1 on antigen presenting cells (APC) modulates the balance between inflammation and tolerance by inducing IL-10 production and apoptosis o...
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Marina Saresella,
Elena Calabrese,
Ivana Marventano,
Federica Piancone,
Andrea Gatti,
Elisabetta Farina,
Margherita Alberoni,
Mario Clerici
et al.
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624.e11-624.e22
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Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice
29 April 2011
Abstract: Pathological hyperphosphorylation and aggregation of the tau protein is associated with dementia and can be the central cause of neurodegeneration. Here, we examined potential alterations in...
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María-Ximena Silveyra,
María-Salud García-Ayllón,
Elena Gómez de Barreda,
David H. Small,
Salvador Martínez,
Jesús Avila,
Javier Sáez-Valero
et al.
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624.e23-624.e34
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Regional differences in age-related lipofuscin accumulation in the female hamster brainstem
09 May 2011
Abstract: Lipofuscin accumulation is a characteristic feature of senescent postmitotic neuronal cells but estrogen may have protecting effects by inhibiting its formation. In the present ultrastructur...
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Peter O. Gerrits,
Rudie Kortekaas,
Henk de Weerd,
Jan G. Veening,
Johannes J.L. van der Want
et al.
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625.e1-625.e9
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Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model
06 May 2011
Abstract: Aging is associated with a deterioration of cognitive performance and with increased risk of neurodegenerative disorders. In the present study we tested whether the specific phosphodiesteras...
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Lourdes Orejana,
Lucía Barros-Miñones,
Joaquín Jordán,
Elena Puerta,
Norberto Aguirre
et al.
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625.e11-625.e20
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Sensory memory during physiological aging indexed by mismatch negativity (MMN)
29 April 2011
Abstract: Physiological aging affects early sensory-perceptual processes. The aim of this experiment was to evaluate changes in auditory sensory memory in physiological aging using the Mismatch Negati...
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Manuela Ruzzoli,
Cornelia Pirulli,
Debora Brignani,
Claudio Maioli,
Carlo Miniussi
et al.
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625.e21-625.e30
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Prolonged coenzyme Q10 treatment in Down syndrome patients, effect on DNA oxidation
25 May 2011
Abstract: Oxidative stress is known to play a relevant role in Down syndrome (DS) and its effects are documented from embryonic life. Oxidative DNA damage has been shown to be significantly elevated i...
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Luca Tiano,
Lucia Padella,
Lucia Santoro,
Paola Carnevali,
Federica Principi,
Francesca Brugè,
Orazio Gabrielli,
Gian Paolo Littarru
et al.
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626.e1-626.e8
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Behavioral and cellular markers of olfactory aging and their response to enrichment
25 May 2011
Abstract: Aging of olfactory function (discrimination and short-term memory) was studied in 2, 10, and 23-month-old mice. We also addressed the issue of the responsiveness of the aging system to olfac...
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Nolwen L. Rey,
Joëlle Sacquet,
Alexandra Veyrac,
François Jourdan,
Anne Didier
et al.
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626.e9-626.e23
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Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice
26 May 2011
Abstract: c-Ret has been shown to be crucial for neural development and survival. We have recently shown that complete impairment of tyrosine 1062 (Y1062)-phosphorylation in c-Ret causes congenital he...
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Nobutaka Ohgami,
Michiru Ida-Eto,
Naomi Sakashita,
Michihiko Sone,
Tsutomu Nakashima,
Keiji Tabuchi,
Tomofumi Hoshino,
Atsuyoshi Shimada,
Toyonori Tsuzuki,
Masahiko Yamamoto,
Gen Sobue,
Mayumi Jijiwa,
Naoya Asai,
Akira Hara,
Masahide Takahashi,
Masashi Kato
et al.
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626.e25-626.e34
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Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's disease
19 May 2011
Abstract: Medial temporal lobe atrophy (MTA) is a recognized marker of Alzheimer's disease (AD), however, it can be prominent in frontotemporal lobar degeneration (FTLD). There is an increasing awaren...
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Manja Lehmann,
Esther L.G.E. Koedam,
Josephine Barnes,
Jonathan W. Bartlett,
Natalie S. Ryan,
Yolande A.L. Pijnenburg,
Frederik Barkhof,
Mike P. Wattjes,
Philip Scheltens,
Nick C. Fox
et al.
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627.e1-627.e12
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Learning capabilities and CA1-prefrontal synaptic plasticity in a mice model of accelerated senescence
10 June 2011
Abstract: SAMP8 mice represent a suitable model of accelerated senescence as compared with SAMR1 animals presenting normal aging. Five-month-old SAMP8 mice presented reflex eyelid responses like those...
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Juan Carlos López-Ramos,
María Teresa Jurado-Parras,
Coral Sanfeliu,
Darío Acuña-Castroviejo,
José M. Delgado-García
et al.
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627.e13-627.e26
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Changes in acetylcholinesterase expression are associated with altered presenilin-1 levels
30 May 2011
Abstract: We have previously identified presenilin-1 (PS1), the active component of the γ-secretase complex, as an interacting protein of the amyloid-associated enzyme acetylcholinesterase (AChE). In ...
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María-Ximena Silveyra,
María-Salud García-Ayllón,
Carol Serra-Basante,
Valeria Mazzoni,
María-Salud García-Gutierrez,
Jorge Manzanares,
Janetta G. Culvenor,
Javier Sáez-Valero
et al.
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627.e27-627.e37
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Association of ApoE and LRP mRNA levels with dementia and AD neuropathology
16 June 2011
Abstract: Inheritance of the ε4 allele of apolipoprotein E (ApoE) is the only confirmed and consistently replicated risk factor for late onset Alzheimer's disease (AD). ApoE is also a key ligand for l...
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Afia Akram,
James Schmeidler,
Pavel Katsel,
Patrick R. Hof,
Vahram Haroutunian
et al.
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628.e1-628.e14
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| Genetic Reports Abstracts |
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Article Title |
Author(s) |
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No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts
11 November 2011
Abstract: The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene has been associated with stroke. The majority of the reported ALOX5AP associations have considered non-radiologically confir...
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Sandra Barral,
Israel Fernández-Cadenas,
Joshua C. Bis,
Joan Montaner,
Arfan M. Ikram,
Lenore J. Launer,
Myriam Fornage,
Helena Schmidt,
Adam M. Brickman,
Sudha Seshadri,
Richard Mayeux
et al.
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629.e1-629.e3
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DLB and PDD: a role for mutations in dementia and Parkinson disease genes?
28 November 2011
Abstract: Based on the substantial overlap in clinical and pathological characteristics of dementia with Lewy bodies (DLB) and Parkinson disease with dementia (PDD) with Alzheimer disease (AD) and Par...
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Bram Meeus,
Aline Verstraeten,
David Crosiers,
Sebastiaan Engelborghs,
Marleen Van den Broeck,
Maria Mattheijssens,
Karin Peeters,
Ellen Corsmit,
Ellen Elinck,
Barbara Pickut,
Rik Vandenberghe,
Patrick Cras,
Peter Paul De Deyn,
Christine Van Broeckhoven,
Jessie Theuns
et al.
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629.e5-629.e18
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Mutational analysis of VCP gene in familial amyotrophic lateral sclerosis
05 December 2011
Abstract: Mutations in valosin-containing protein (VCP) gene, already known to be associated with the multisystemic disorder, inclusion body myopathy with Paget's disease and frontotemporal dementia (...
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Cinzia Tiloca,
Antonia Ratti,
Viviana Pensato,
Alessia Castucci,
Gianni Sorarù,
Roberto Del Bo,
Lucia Corrado,
Cristina Cereda,
Carla D'Ascenzo,
Giacomo P. Comi,
Letizia Mazzini,
Barbara Castellotti,
Nicola Ticozzi,
Cinzia Gellera,
Vincenzo Silani,
SLAGEN Consortium
et al.
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630.e1-630.e2
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UNC13A is a modifier of survival in amyotrophic lateral sclerosis
28 November 2011
Abstract: A large genome-wide screen in patients with sporadic amyotrophic lateral sclerosis (ALS) showed that the common variant rs12608932 in gene UNC13A was associated with disease susceptibility. ...
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Frank P. Diekstra,
Paul W.J. van Vught,
Wouter van Rheenen,
Max Koppers,
R. Jeroen Pasterkamp,
Michael A. van Es,
Helenius J. Schelhaas,
Marianne de Visser,
Wim Robberecht,
Philip Van Damme,
Peter M. Andersen,
Leonard H. van den Berg,
Jan H. Veldink
et al.
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630.e3-630.e8
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632-634
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