Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects

Samuraki, Miharu; Matsunari, Ichiro; Chen, Wei-Ping; Shima, Keisuke; Yanase, Daisuke; Takeda, Nozomi; Matsuda, Hiroshi; Yamada, Masahito

doi:10.1016/j.neurobiolaging.2011.11.020

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Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects

Miharu Samuraki
- Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa-city, Ishikawa, Japan
- Corresponding author at: Department of Neurology and Neurobiology of Aging, Kanazawa University, Graduate School of Medical Science, 13–1, Takara-town, Kanazawa-city, Ishikawa 920-8640, Japan. Tel.: +81 76 265 2292; fax: +81 76 234 4253
Ichiro Matsunari
- The Medical and Pharmacological Research Center Foundation, Hakui-city, Ishikawa, Japan
Wei-Ping Chen
- The Medical and Pharmacological Research Center Foundation, Hakui-city, Ishikawa, Japan
Keisuke Shima
- Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa-city, Ishikawa, Japan
Daisuke Yanase
- Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa-city, Ishikawa, Japan
Nozomi Takeda
- The Medical and Pharmacological Research Center Foundation, Hakui-city, Ishikawa, Japan
Hiroshi Matsuda
- Department of Nuclear Medicine, Saitama Medical University International Medical Center, Hidaka-city, Saitama, Japan
Masahito Yamada
- Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa-city, Ishikawa, Japan

Received 3 November 2010; received in revised form 10 November 2011; accepted 12 November 2011. published online 22 December 2011.
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Abstract

Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively normal ApoE ε4 carriers using ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM). Forty-five cognitive normal ApoE ε4 allele carriers and 45 noncarriers underwent both FDG positron emission tomography and magnetic resonance imaging (MRI). A total of 90 normal database sets were generated for the individual 45 ε4 carriers and 45 noncarriers. Mean z-scores in the predefined AD-specific regions of interest (ROI) were calculated for each ε4 carrier and noncarrier using the individually defined normal database. The prevalence of AD-like hypometabolism and atrophy in the ε4 carriers was 8.9% and 17.7%, respectively, and did not differ significantly from those in the noncarriers (8.9%, 8.8%). The majority of ε4 carriers showed preserved FDG uptake or gray matter concentration.

Keywords: Alzheimer's disease , FDG PET , ApoE ε4