Neurobiology of Aging
Volume 33, Issue 3 , Pages 629.e1-629.e3, March 2012

No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts

  • Sandra Barral

      Affiliations

    • The Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA
    • Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    • Corresponding Author InformationCorresponding author at: Columbia University Medical Center, The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA. Tel.: +1 212 305 5139; fax: +1 212 305 2426
    • ,
  • Israel Fernández-Cadenas

      Affiliations

    • Neurovascular Research Laboratory Institut de Recerca, Vall d'Hebron Hospital, Universitat Autonoma de Barcelona, Paseo Vall d'Hebron 119-129, 08035, Barcelona, Spain
    • ,
  • Joshua C. Bis

      Affiliations

    • Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
    • Department of Medicine, University of Washington, Seattle, WA, USA
    • ,
  • Joan Montaner

      Affiliations

    • Neurovascular Research Laboratory Institut de Recerca, Vall d'Hebron Hospital, Universitat Autonoma de Barcelona, Paseo Vall d'Hebron 119-129, 08035, Barcelona, Spain
    • ,
  • Arfan M. Ikram

      Affiliations

    • Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    • Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    • Netherlands Consortium for Healthy Aging, The Netherlands
    • ,
  • Lenore J. Launer

      Affiliations

    • Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD, USA
    • ,
  • Myriam Fornage

      Affiliations

    • Brown Foundation Institute of Molecular Medicine, Division of Epidemiology School of Public Health, University of Texas Health Science Center at Houston, TX, USA
    • Human Genetics Center, Division of Epidemiology School of Public Health, University of Texas Health Science Center at Houston, TX, USA
    • ,
  • Helena Schmidt

      Affiliations

    • Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria
    • ,
  • Adam M. Brickman

      Affiliations

    • The Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA
    • Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    • Department of Neurology, Columbia University Medical Center, New York, NY, USA
    • ,
  • Sudha Seshadri

      Affiliations

    • Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    • ,
  • Richard Mayeux

      Affiliations

    • The Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA
    • Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    • Department of Neurology, Columbia University Medical Center, New York, NY, USA

Received 11 March 2011; received in revised form 19 August 2011; accepted 12 October 2011. published online 11 November 2011.

Abstract 

The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene has been associated with stroke. The majority of the reported ALOX5AP associations have considered non-radiologically confirmed infarcts as the stroke phenotype. We assessed the association of genetic variants in ALOX5AP with stroke defined by the presence of infarcts on brain magnetic resonance imaging (MRI). We studied 202 persons with MRI-defined brain infarcts and 487 healthy individuals of Caribbean Hispanic ancestry. Another sample of European ancestry comprised 1823 persons with MRI-defined brain infarct and 7578 control subjects. Subjects were genotyped for the 4 single nucleotide polymorphisms (SNPs) that define ALOX5AP HapA haplotype. No association was found between SNPs and MRI-defined brain infarcts. Our data do not support the hypothesis that variants in ALOX5AP are associated with risk of MRI-defined brain infarcts.

Keywords:  MRI-defined brain infarcts , ALOX5AP

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PII: S0197-4580(11)00406-4

doi:10.1016/j.neurobiolaging.2011.10.010

Neurobiology of Aging
Volume 33, Issue 3 , Pages 629.e1-629.e3, March 2012

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