Neurobiology of Aging
Volume 32, Issue 3 , Pages 554.e7-554.e11 , March 2011

Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old

  • Jonas Mengel-From

      Affiliations

    • The Danish Aging Research Center, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    • Department of Clinical Biochemistry and Clinical Genetics, Odense University Hospital, Odense, Denmark
    • Corresponding Author InformationCorresponding author at: The Danish Aging Research Center, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9, DK-5000 Odense, Denmark. Tel.: +45 6550 4082; fax: +45 6550 3682
    • ,
  • Kaare Christensen

      Affiliations

    • The Danish Aging Research Center, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    • ,
  • Matt McGue

      Affiliations

    • The Danish Aging Research Center, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    • Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Lene Christiansen

      Affiliations

    • The Danish Aging Research Center, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    • Department of Clinical Biochemistry and Clinical Genetics, Odense University Hospital, Odense, Denmark

Received 16 February 2010 ,Revised 7 July 2010 ,Accepted 19 July 2010.

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  3. Bookheimer S, Burggren A. APOE-4 genotype and neurophysiological vulnerability to Alzheimer's and cognitive aging. Annu. Rev. Clin. Psychol. 2009;5:343–362
  4. Campion D, Dumanchin C, Hannequin D, Dubois B, Belliard S, Puel M, et al. Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. Am. J. Hum. Genet. 1999;65:664–670
  5. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet. 2009;41:1088–1093
  6. Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease. Nat. Genet. 2009;41:1094–1099
  7. Mario A. Cleves. Exploratory analysis of single nucleotide polymorphism (SNP) for quantitative traits. STATA J. 2005;5:141–153
  8. McGue M, Christensen K. The heritability of cognitive functioning in very old adults: evidence from Danish twins aged 75 years and older. Psychol. Aging. 2001;16:272–280
  9. McGue M, Christensen K. The heritability of level and rate-of-change in cognitive functioning in Danish twins aged 70 years and older. Exp. Aging Res. 2002;28:435–451
  10. Nybo H, Petersen HC, Gaist D, Jeune B, Andersen K, McGue M, et al. Predictors of mortality in 2,249 nonagenarians − the Danish 1905-Cohort Survey. J. Am. Geriatr. Soc. 2003;51:1365–1373
  11. Small BJ, Rosnick CB, Fratiglioni L, Backman L. Apolipoprotein E and cognitive performance: a meta-analysis. Psychol. Aging. 2004;19:592–600

PII: S0197-4580(10)00324-6

doi: 10.1016/j.neurobiolaging.2010.07.016

Neurobiology of Aging
Volume 32, Issue 3 , Pages 554.e7-554.e11 , March 2011

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