Neurobiology of Aging
Volume 33, Issue 1 , Pages 199.e13-199.e17 , January 2012

Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels

  • Christiane Reitz

      Affiliations

    • The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
    • The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
    • Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • ,
  • Rong Cheng

      Affiliations

    • The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
    • The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
    • Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA
    • ,
  • Nicole Schupf

      Affiliations

    • The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
    • The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
    • Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA
    • ,
  • Joseph H. Lee

      Affiliations

    • The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
    • The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
    • Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA
    • ,
  • Pankaj D. Mehta

      Affiliations

    • Department of Immunology, Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    • ,
  • Ekaterina Rogaeva

      Affiliations

    • Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    • ,
  • Peter St George-Hyslop

      Affiliations

    • Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    • Department of Medicine, University Health Network, Toronto, Ontario, Canada
    • Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    • ,
  • Richard Mayeux

      Affiliations

    • The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
    • The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
    • Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA
    • Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • Corresponding Author InformationCorresponding author at: Gertrude H. Sergievsky Center, 630 West 168th Street, Columbia University, New York, NY 10032, USA. Tel.: +1 212 305 3192; fax: +1 212 305 2518

Received 7 April 2010 ,Revised 29 June 2010 ,Accepted 5 July 2010.

References 

  1. Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, et al. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science. 2000;290:2302–2303
  2. Cousin E, Mace S, Rocher C, Dib C, Muzard G, Hannequin D, et al. No replication of genetic association between candidate polymorphisms and Alzheimer's disease. Neurobiol. Aging. 2009;Epub ahead of print, Nov. 2
  3. Ertekin-Taner N, Allen M, Fadale D, Scanlin L, Younkin L, Petersen RC, et al. Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. Hum. Mutat. 2004;23:334–342
  4. Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. U. S. A. 2003;100:4162–4167
  5. Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, et al. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003;40:1087–1093
  6. Nyholt DR. Genetic case-control association studies − correcting for multiple testing. Hum. Genet. 2001;109:564–567
  7. Perez A, Morelli L, Cresto JC, Castano EM. Degradation of soluble amyloid beta-peptides 1–40, 1–42, and the Dutch variant 1–40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochem. Res. 2000;25:247–255
  8. Prince JA, Feuk L, Gu HF, Johansson B, Gatz M, Blennow K, et al. Genetic variation in a haplotype block spanning IDE influences Alzheimer disease. Hum. Mutat. 2003;22:363–371
  9. Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, et al. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron. 2007;54:713–720
  10. Romas SN, Santana V, Williamson J, Ciappa A, Lee JH, Rondon HZ, et al. Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE. Arch. Neurol. 2002;59:87–91
  11. Rudovich N, Pivovarova O, Fisher E, Fischer-Rosinsky A, Spranger J, Mohlig M, et al. Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes. J. Mol. Med. 2009;87:1145–1151
  12. Tang MX, Stern Y, Marder K, Bell K, Gurland B, Lantigua R, et al. The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics. JAMA. 1998;279:751–755
  13. Zou F, Carrasquillo MM, Pankratz VS, Belbin O, Morgan K, Allen M, et al. Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease. Neurology. 2010;74:480–486

PII: S0197-4580(10)00312-X

doi: 10.1016/j.neurobiolaging.2010.07.005

Neurobiology of Aging
Volume 33, Issue 1 , Pages 199.e13-199.e17 , January 2012

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