Neurobiology of Aging
Volume 33, Issue 1 , Pages 199.e13-199.e17 , January 2012

Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels

  • Christiane Reitz

      Affiliations

    • The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
    • The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
    • Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • ,
  • Rong Cheng

      Affiliations

    • The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
    • The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
    • Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA
    • ,
  • Nicole Schupf

      Affiliations

    • The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
    • The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
    • Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA
    • ,
  • Joseph H. Lee

      Affiliations

    • The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
    • The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
    • Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA
    • ,
  • Pankaj D. Mehta

      Affiliations

    • Department of Immunology, Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    • ,
  • Ekaterina Rogaeva

      Affiliations

    • Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    • ,
  • Peter St George-Hyslop

      Affiliations

    • Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    • Department of Medicine, University Health Network, Toronto, Ontario, Canada
    • Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    • ,
  • Richard Mayeux

      Affiliations

    • The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
    • The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
    • Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA
    • Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • Corresponding Author InformationCorresponding author at: Gertrude H. Sergievsky Center, 630 West 168th Street, Columbia University, New York, NY 10032, USA. Tel.: +1 212 305 3192; fax: +1 212 305 2518

Received 7 April 2010 ,Revised 29 June 2010 ,Accepted 5 July 2010.

  • Image Result

    Linkage disequilibrium (LD) pattern of the 10q region spanning IDE, KIF11, and HHEX in the present sample. The boxes indicate SNPs significant in the present analyses, the black arrows indicate SNPs s

    Linkage disequilibrium (LD) pattern of the 10q region spanning IDE, KIF11, and HHEX in the present sample. The boxes indicate SNPs significant in the present analyses, the black arrows indicate SNPs significant in the study by Ertekin-Taner (2004). The green arrow indicates the SNPs that have been shown to influence IDE expression in LOAD brain samples in the study by Zou et al. (2010)

PII: S0197-4580(10)00312-X

doi: 10.1016/j.neurobiolaging.2010.07.005

Neurobiology of Aging
Volume 33, Issue 1 , Pages 199.e13-199.e17 , January 2012

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