Neurobiology of Aging
Volume 33, Issue 5 , Pages 1015.e25-1015.e26 , May 2012

No association between DNA repair gene XRCC1 and amyotrophic lateral sclerosis

  • Fang Fang

      Affiliations

    • Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    • Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationCorresponding author at: P.O. Box 281, Karolinska Institutet, Stockholm 171 77, Sweden. Tel: +46 8 524 86131; fax: +46 8 31 49 75
    • ,
  • David M. Umbach

      Affiliations

    • Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    • ,
  • Zongli Xu

      Affiliations

    • Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    • ,
  • Weimin Ye

      Affiliations

    • Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Dale P. Sandler

      Affiliations

    • Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    • ,
  • Jack A. Taylor

      Affiliations

    • Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    • ,
  • Freya Kamel

      Affiliations

    • Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA

Received 14 May 2010 ,Revised 1 July 2010 ,Accepted 5 July 2010.

References 

  1. Bradley WG , Krasin F . A new hypothesis of the etiology of amyotrophic lateral sclerosis (The DNA hypothesis) . Arch. Neurol . 1982;39:677–680
  2. Cronin S, Berger S, Ding J, Schymick JC, Washecka N, Hernandez DG, et al. A genomewide association study of sporadic ALS in a homogenous Irish population . Hum. Mol. Genet . 2008;17:768–774
  3. Kamel F , Umbach DM , Munsat TL , Shefner JM , Hu H , Sandler DP . Lead exposure and amyotrophic lateral sclerosis . Epidemiology . 2002;13:311–319
  4. Schymick JC, Scholz SW, Fung HC, Britton A, Arepalli S, Gibbs JR, et al. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls, first stage analysis and public release of data . Lancet Neurol . 2007;6:322–328
  5. Stephens M , Smith NJ , Donnelly P . A new statistical method for haplotype reconstruction from population data . Am. J. Hum. Genet. . 2001;68:978–989

PII: S0197-4580(10)00311-8

doi: 10.1016/j.neurobiolaging.2010.07.004

Neurobiology of Aging
Volume 33, Issue 5 , Pages 1015.e25-1015.e26 , May 2012

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