Neurobiology of Aging
Volume 33, Issue 6 , Pages 1085-1095 , June 2012

Age-related increase of sIAHP in prefrontal pyramidal cells of monkeys: relationship to cognition

Received 13 May 2010 ,Revised 23 June 2010 ,Accepted 5 July 2010.

References 

  1. Barnes CA . Long-term potentiation and the ageing brain . Philos. Trans. R. Soc. Lond. B Biol. Sci . 2003;358:765–772
  2. Barnes CA , McNaughton BL , O'Keefe J . Loss of place specificity in hippocampal complex spike cells of senescent rat . Neurobiol. Aging . 1983;4:113–119
  3. Bartus JM , Dean RL , Fleming D . Aging in the rhesus monkey: effects on visual discrimination learning and reversal learning . J. Gerontol . 1979;34:209–219
  4. Burke SN , Barnes CA . Neural plasticity in the ageing brain . Nat. Rev. Neurosci . 2006;7:30–40
  5. Burke SN , Barnes CA . Senescent synapses and hippocampal circuit dynamics . Trends Neurosci . 2010;33:153–161
  6. Chang Y , Rosene DL , Killiany RJ , Mangiamele LA , Luebke JL . Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys . Cereb. Cortex . 2005;15:409–418
  7. Clodfelter GV , Porter NM , Landfield PW , Thibault O . Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons . Eur. J. Pharmacol . 2002;447:189–200
  8. Dickstein DL , Kabaso D , Rocher AB , Luebke JI , Wearne SL , Hof PR . Changes in the structural complexity of the aged brain . Aging Cell . 2007;6:275–284
  9. Disterhoft JF , Coulter DA , Alkon DL . Conditioning-specific membrane changes of rabbit hippocampal neurons measured in vitro . Proc. Natl. Acad. Sci. USA . 1986;83:2733–2737
  10. Disterhoft JF , Thompson LT , Moyer JR , Mogul DJ . Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus . Life Sci . 1996;59:413–420
  11. Faber ES , Sah P . Calcium-activated potassium channels: multiple contributions to neuronal function . Neuroscientist . 2003;9:181–194
  12. Foster TC . Calcium homeostasis and modulation of synaptic plasticity in the aged brain . Aging Cell . 2007;6:319–325
  13. Gant JC , Sama MM , Landfield PW , Thibault O . Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release . J. Neurosci . 2006;26:3482–3490
  14. Herndon JG , Moss MB , Rosene DL , Killiany RJ . Patterns of cognitive decline in aged rhesus monkeys . Behav. Brain Res . 1997;87:25–35
  15. Lai ZC , Moss MB , Killiany RJ , Rosene DL , Herndon JG . Executive system dysfunction in the aged monkey: spatial and object reversal learning . Neurobiol. Aging . 1995;16:947–954
  16. Landfield PW , Pitler TA . Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats . Science . 1984;226:1089–1092
  17. Leventhal AG , Wang Y , Pu M , Zhou Y , Ma Y . GABA and its agonists improved visual cortical function in senescent monkeys . Science . 2003;300:812–815
  18. Luebke JI , Barbas H , Peters A . Effects of normal aging on prefrontal area 46 in the rhesus monkey . Brain Res. Rev . 2010;62:212–232
  19. Luebke JI , Chang Y . Effects of aging on the electrophysiological properties of layer 5 pyramidal cells in the prefrontal cortex . Neuroscience . 2007;150:556–562
  20. Luebke JI , Chang Y , Moore TL , Rosene DL . Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex . Neuroscience . 2004;125:277–288
  21. Kumar A , Foster TC . 17beta-estradiol benzoate decreases the AHP amplitude in CA1 pyramidal neurons . J. Neurophysiol . 2002;88:621–626
  22. Kumar A , Foster TC . Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores . J. Neurophysiol . 2004;91:2437–2444
  23. Matthews EA , Linardakis JM , Disterhoft JF . The fast and slow afterhyperpolarizations are differentially modulated in hippocampal neurons by aging and learning . J. Neurosci . 2009;29:4750–4755
  24. Moore TL , Killiany RJ , Herndon JG , Rosene DL , Moss MB . Impairment in abstraction and set shifting in aged rhesus monkeys . Neurobiol. Aging . 2003;24:125–134
  25. Moore TL , Killiany RJ , Herndon JG , Rosene DL , Moss MB . Executive system dysfunction occurs as early as middle-age in the rhesus monkey . Neurobiol. Aging . 2006;27:1484–1493
  26. Moore TL, Schettler SP, Killiany RJ, Herndon JG, Luebke JI, Moss MB, et al. Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex . Behav. Brain Res . 2005;160:208–221
  27. Morrison JH , Hof PR . Selective vulnerability of corticocortical and hippocampal circuits in aging Alzheimer's disease . Prof Brain. Resources . 2002;136:467–486
  28. Morrison JH , Hof PR . Life and death of neurons in the aging cerebral cortex . Int. Rev. Neurobiol . 2007;81:41–57
  29. Moyer JR , Thompson LT , Black JP , Disterhoft JF . Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner . J. Neurophysiol . 1992;68:2100–2109
  30. Moyer JR , Power JM , Thompson LT , Disterhoft JF . Increased excitability of aged rabbit CA1 neurons after trace eyeblink conditioning . J. Neurosci . 2000;20:5476–5482
  31. Norris CM , Halpain S , Foster TC . Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels . J. Neurosci . 1998;18:3171–3179
  32. Oler JA , Markus EJ . Age-related deficits in the ability to encode contextual change: a place cell analysis . Hippocampus . 2000;10:338–350
  33. Power JM , Wu WW , Sametsky E , Oh MM , Disterhoft JF . Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro . J. Neurosci . 2002;22:7234–7243
  34. Rapp PR . Visual discrimination and reversal learning in the aged monkey (Macaca mulatta) . Behav. Neurosci . 1990;104:876–884
  35. Sah P , Bekkers JM . Apical dendritic location of slow afterhyperpolarization current in hippocampal pyramidal neurons: implications for the integration of long-term potentiation . J. Neurosci . 1996;16:4537–4542
  36. Sah P , Isaacson JS . Channels underlying the slow afterhyperpolarization in hippocampal pyramidal neurons: neurotransmitters modulate the open probability . Neuron . 1995;15:435–441
  37. Sava S , Markus EJ . Activation of the medial septum reverses age-related hippocampal encoding deficits: a place field analysis . J. Neurosci . 2008;28:1841–1853
  38. Schmolesky MT , Wang Y , Pu M , Leventhal AG . Degradation of stimulus selectivity of visual cortical cells in senescent rhesus monkeys . Nat. Neurosci . 2000;3:384–390
  39. Shen J , Barnes CA , McNaughton BL , Skaggs WE , Weaver KL . The effect of aging on experience-dependent plasticity of hippocampal place cells . J. Neurosci . 1997;17:6769–6782
  40. Steere JC , Arnsten AF . The a-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys . Behav. Neurosci . 1997;111:883–891
  41. Tanila H , Sipilä P , Shapiro M , Eichenbaum H . Brain aging: impaired coding of novel environmental cues . J. Neurosci . 1997;17:5167–5174
  42. Thibault O , Gant JC , Landfield PW . Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store . Aging Cell . 2007;6:307–317
  43. Thibault O , Hadley R , Landfield PW . Elevated postsynaptic [Ca2+]I and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity . J. Neurosci . 2001;21:9744–9756
  44. Thibault O , Landfield PW . Increase in single L-type calcium channels in hippocampal neurons during aging . Science . 1996;272:1017–1020
  45. Thibault O, Porter NM, Chen K-C, Blalock EM, Kaminker PG, Clodfelter GV, et al. Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions . Trends Neurosci . 1998;24:417–433
  46. Thompson LT , Moyer JR , Disterhoft JF . Transient changes in excitability of rabbit CA3 neurons with a time course appropriate to support memory consolidation . J. Neurophysiol . 1996;56:103–110
  47. Tombaugh GC , Rowe WB , Rose GM . The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats . J. Neurosci . 2005;25:2609–2616
  48. Vannucchi MG , Goldman-Rakic PS . Age-dependent decrease in the affinity of muscarinic M1 receptors in neocortex of rhesus monkeys . Proc. Natl. Acad. Sci. USA . 1991;88:11475–11479
  49. Wilson IA , Ikonen S , Gallagher M , Eichenbaum H , Tanila H . Age-associated alterations of hippocampal place cells are subregion specific . J. Neurosci . 2005;25:6877–6886
  50. Zhang J, Wang X, Wang Y, Fu Y, Liang Z, Ma Y, et al. Spatial and temporal sensitivity degradation of primary visual cortical cells in senescent rhesus monkeys . Eur. J. Neurosci . 2008;28:201–207

PII: S0197-4580(10)00309-X

doi: 10.1016/j.neurobiolaging.2010.07.002

Neurobiology of Aging
Volume 33, Issue 6 , Pages 1085-1095 , June 2012

Article Tools

* Image Usage & Resolution