Neurobiology of Aging
Volume 33, Issue 1 , Pages 197.e1-197.e9 , January 2012

White matter hyperintensities alter functional organization of the motor system

  • Patricia Linortner

      Affiliations

    • Department of Neurology, Medical University of Graz, Graz, Austria
    • Laboratory of Brain-Computer Interfaces, Institute for Knowledge Discovery, Graz Institute of Technology Graz, Graz, Austria
    • Department of Psychology, Karl-Franzens University Graz, Graz, Austria
    • ,
  • Franz Fazekas

      Affiliations

    • Department of Neurology, Medical University of Graz, Graz, Austria
    • ,
  • Reinhold Schmidt

      Affiliations

    • Department of Neurology, Medical University of Graz, Graz, Austria
    • ,
  • Stefan Ropele

      Affiliations

    • Department of Neurology, Medical University of Graz, Graz, Austria
    • ,
  • Barbara Pendl

      Affiliations

    • Department of Neurology, Medical University of Graz, Graz, Austria
    • ,
  • Katja Petrovic

      Affiliations

    • Department of Neurology, Medical University of Graz, Graz, Austria
    • ,
  • Marisa Loitfelder

      Affiliations

    • Department of Neurology, Medical University of Graz, Graz, Austria
    • Department of Psychology, Karl-Franzens University Graz, Graz, Austria
    • ,
  • Christa Neuper

      Affiliations

    • Laboratory of Brain-Computer Interfaces, Institute for Knowledge Discovery, Graz Institute of Technology Graz, Graz, Austria
    • Department of Psychology, Karl-Franzens University Graz, Graz, Austria
    • ,
  • Christian Enzinger

      Affiliations

    • Department of Neurology, Medical University of Graz, Graz, Austria
    • Section of Neuroradiology, Department of Radiology, Medical University of Graz, Graz, Austria
    • Corresponding Author InformationCorresponding author at: Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A-8036 Graz, Austria. Tel.: +43 316 385 82180; fax: +43 316 385 6808

Received 20 April 2010 ,Revised 6 June 2010 ,Accepted 9 June 2010.

References 

  1. Baezner H, Blahak C, Poggesi A, Pantoni L, Inzitari D, Chabriat H, et al. Association of gait and balance disorders with age-related white matter changes (The LADIS study). Neurology. 2008;70:935–942
  2. Blahak C, Baezner H, Pantoni L, Poggesi A, Chabriat H, Erkinjuntti T, et al. Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are associated with falls: cross sectional results from the LADIS study. J. Neurol. Neurosurg. Psychiatry. 2009;80:608–613
  3. Capaday C. The special nature of human walking and its neural control. Trends Neurosci. 2002;25:370–376
  4. Connolly J, Goodale M, Cant J, Munoz D. Effector-specific fields for motor preparation in the human frontal cortex. Neuroimage. 2007;34:1209–1219
  5. Cummings JL. Frontal-subcortical circuits and human behavior. Arch. Neurol. 1993;50:873–880
  6. Deyoe E. Occipital lobe. In:  Ramachandran VS editors. Encyclopedia of the Human Brain. San Diego: Academic Press; 2002;
  7. DuBoisgueheneuc F, Levy R, Volle E, Seassau M, Duffau H, Kinkingnehun S, et al. Functions of the left superior frontal gyrus in humans: a lesion study. Brain. 2006;129:3315–3328
  8. Enzinger C, Dawes H, Johansen-Berg H, Wade D, Bogdanovic M, Collett J, et al. Brain activity changes associated with treadmill training after stroke. Stroke. 2009;40:2460–2467
  9. Enzinger C, Johansen-Berg H, Dawes H, Bogdanovic M, Collett J, Guy C, et al. Functional MRI correlates of lower limb function in stroke victims with gait impairment. Stroke. 2008;39:1–7
  10. Fazekas F, Chawluk J, Alavi A, Hurtig H, Zimmerman R. MR signal abnormalities at 15T in Alzheimer's dementia and normal aging. AJR Am. J. Roentgenol. 1987;149:351–356
  11. Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology. 1993;43:1683–1689
  12. Frisoni G, Galluzzi S, Pantoni L, Filippi M. The effect of white matter lesions on cognition in the elderly − small but detectable. Nat. Clin. Pract. Neurol. 2007;3:620–627
  13. Galluzzi S, Lanni C, Pantoni L, Filippi M, Frisoni G. White matter lesions in the elderly: Pathophysiological hypothesis on the effect on brain plasticity and repair. J. Neurol. Sci. 2008;278:3–9
  14. Inzitari D, Pracucci G, Poggesi A, Carlucci G, Barkhof F, Chabriat H, et al. Changes in white matter as determinant of global functional decline in older independent outpatients: three-year follow-up of LADIS (leukoaraiosis and disability) study cohort. BMJ. 2009;339:b2477
  15. Johansen-Berg H, Behrens TE, Robson MD, Drobnjak I, Rushworth MF, Brady JM, et al. Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex. Proc. Natl. Acad. Sci. U. S. A. 2004;101:13335–13340
  16. Jueptner M, Stephan K, Frith CD, Brooks DJ, Frackowiak RS, Passingham RE. Anatomy of motor learning (I. Frontal cortex and attention to action). J. Neurophysiol. 1997;77:1313–1324
  17. Koechlin E, Ody C, Kouneiher F. The architecture of cognitive control in the human prefrontal cortex. Science. 2003;302:1181–1185
  18. Luft A, Smith G, Forrester L, Whitall J, Macko RF, Hauser TK, et al. Comparing brain activation associated with isolated upper and lower limb movement across corresponding joints. Hum. Brain Mapp. 2002;17:131–140
  19. Nachev P, Kennard C, Husain M. Functional role of the supplementary and pre-supplementary motor areas. Nat. Rev. Neurosci. 2009;9:856–869
  20. Pantoni L, Basile A, Pracucci G, Asplund K, Bogousslavsky J, Chabriat H, et al. Impact of age-related cerebral white matter changes on the transition to disability – the LADIS study: rationale, design and methodology. Neuroepidemiology. 2005;24:51–62
  21. Picard N. Motor areas of the medial wall: A review of their location and functional activation. Cereb. Cortex. 1996;6:342–353
  22. Picard N, Strick P. Imaging the premotor areas. Curr. Opin. Neurobiol. 2001;11:663–672
  23. Raz N. Aging of the brain and its impact on cognitive performance: Integration of structural and functional findings. In:  Craik FIM,  Salthouse TA editor. The Handbook of Aging and Cognition. second ed.. Mahwah: Lawrence Erlbaum Associates; 2000;
  24. Rocca MA, Colombo B, Falini A, Ghezzi A, Martinelli V, Filippi M. Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes. Lancet Neurol. 2005;4:618–626
  25. Rotte M, Kanowski M, Heinze HJ. Functional magnetic resonance imaging for the evaluation of the motor system: Primary and secondary brain areas in different motor tasks. Stereotact. Funct. Neurosurg. 2002;78:3–16
  26. Schmidt R, Enzinger C, Ropele S, Schmidt H, Fazekas F. Progression of cerebral white matter lesions: 6-year results of the Austrian Stroke Prevention Study. Lancet. 2003;361:2046–2048
  27. Schmidt R, Scheltens P, Erkinjuntti T, Pantoni L, Markus HS, Wallin A, et al. White matter lesion progression: a surrogate endpoint for trials in cerebral small-vessel disease. Neurology. 2004;63:139–144
  28. Srikanth TG, Phan J, Chen R, Beare J, Stapleton JM, Reutens DC. Bilateral frontal periventricular locations of cerebral white matter lesions show greatest covariance with poorer gait. Cerebrovasc. Dis. 2010;29(suppl 2):(abstract)
  29. Thompson PD, Marsden CD. Gait disorder of subcortical arteriosclerotic encephalopathy: Binswanger's disease. Mov. Disord. 1987;2:1–8
  30. Wegner C, Filippi M, Korteweg T, Beckmann C, Ciccarelli O, De Stefano N, et al. Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study. Eur. J. Neurol. 2008;15:113–122
  31. West RL. An application of prefrontal cortex function theory to cognitive aging. Psychol. Bull. 1996;120:272–292

PII: S0197-4580(10)00257-5

doi: 10.1016/j.neurobiolaging.2010.06.005

Neurobiology of Aging
Volume 33, Issue 1 , Pages 197.e1-197.e9 , January 2012

Article Tools

* Image Usage & Resolution