Neurobiology of Aging
Volume 33, Issue 3 , Pages 457-465 , March 2012

Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease

  • Becky Inkster

      Affiliations

    • GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
    • Department of Clinical Neuroscience, Imperial College, London, United Kingdom
    • Corresponding Author InformationCorresponding author at: Imperial College London, Hammersmith Campus, Room 313, Third Floor, Burlington Danes Building, Du Cane Road, London W12 0NN, United Kingdom. Tel.: +44 (0)20 7594 7993
  • ,
  • Anil W. Rao

      Affiliations

    • GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
  • ,
  • Khanum Ridler

      Affiliations

    • GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
  • ,
  • Nicola Filippini

      Affiliations

    • Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom
    • LENITEM, Laboratory of Epidemiology, Neuroimaging and Telemedicine-IRCCS, S. Giovanni di Dio-FBF, Brescia, Italy
    • Department of Psychiatry, University of Oxford, Oxford, United Kingdom
  • ,
  • Brandon Whitcher

      Affiliations

    • GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
  • ,
  • Thomas E. Nichols

      Affiliations

    • GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
    • Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom
  • ,
  • Sally Wetten

      Affiliations

    • GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
  • ,
  • Rachel A. Gibson

      Affiliations

    • GlaxoSmithKline, Harlow, United Kingdom
  • ,
  • Michael Borrie

      Affiliations

    • University of Western Ontario, London, ON, Canada
  • ,
  • Andrew Kertesz

      Affiliations

    • University of Western Ontario, London, ON, Canada
  • ,
  • Danilo A. Guzman

      Affiliations

    • University of Ottawa, Ottawa, ON, Canada
  • ,
  • Inge Loy-English

      Affiliations

    • University of Ottawa, Ottawa, ON, Canada
  • ,
  • Julie Williams

      Affiliations

    • MRC Neuropsychiatric Genetics Group, School of Medicine, Cardiff University, Cardiff, United Kingdom
  • ,
  • Philipp G. Saemann

      Affiliations

    • Max Planck Institute of Psychiatry, Munich, Germany
  • ,
  • Dorothee P. Auer

      Affiliations

    • Max Planck Institute of Psychiatry, Munich, Germany
  • ,
  • Florian Holsboer

      Affiliations

    • Max Planck Institute of Psychiatry, Munich, Germany
  • ,
  • Federica Tozzi

      Affiliations

    • Genetics Division, Drug Discovery, Medicine Development Centre, GlaxoSmithKline, Research and Development, Verona, Italy
  • ,
  • Pierandrea Muglia

      Affiliations

    • Genetics Division, Drug Discovery, Medicine Development Centre, GlaxoSmithKline, Research and Development, Verona, Italy
  • ,
  • Emilio Merlo-Pich

      Affiliations

    • Experimental Medical Science, Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Verona, Italy
  • ,
  • Paul M. Matthews

      Affiliations

    • GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
    • Department of Clinical Neuroscience, Imperial College, London, United Kingdom

Received 17 January 2010 ,Revised 8 April 2010 ,Accepted 20 April 2010.

References 

  1. Allen Brain Atlas www.brain-map.org
  2. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders . fourth ed.. Washington, DC: American Psychiatric Association; 1994;
  3. Antúnez C, Boada M, López-Arrieta J, Ramirez-Lorca R, Hernández I, Marín J, et al. GOLPH2 gene markers are not associated with Alzheimer's disease in a sample of the Spanish population . J. Alzheimers Dis. . 2009;18:751–754
  4. Bachert C , Fimmel C , Linstedt AD . Endosomal trafficking and proprotein convertase cleavage of cis Golgi protein GP73 produces marker for hepatocellular carcinoma . Traffic . 2007;8:1415–1423
  5. Badre D , Wagner AD . Left ventrolateral prefrontal cortex and the cognitive control of memory . Neuropsychologia . 2007;45:2883–2901
  6. Barnes J, Bartlett JW, van de Pol LA, Loy CT, Scahill RI, Frost C, et al. A meta-analysis of hippocampal atrophy rates in Alzheimer's disease . Neurobiol. Aging . 2009;30:1711–1723
  7. Barrett JC , Fry B , Maller J , Daly MJ . Haploview: analysis and visualization of LD and haplotype maps . Bioinformatics . 2005;21:263–265
  8. Blacker D, Bertram L, Saunders AJ, Moscarillo TJ, Albert MS, Wiener H, et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families . Hum. Mol. Genet. . 2003;12:23–32
  9. Boccardi M , Sabattoli F , Testa C , Beltramello A , Soininen H , Frisoni GB . APOE and modulation of Alzheimer's and frontotemporal dementia . Neurosci. Lett. . 2004;356:167–170
  10. Chan D, Janssen JC, Whitwell JL, Watt HC, Jenkins R, Frost C, et al. Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: longitudinal MRI study . Lancet . 2003;362:1121–1122
  11. Curtis D , North BV , Sham PC . A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease . Ann. Hum. Genet. . 2001;65(Pt 5):473–481
  12. Filippini N, Rao A, Wetten S, Gibson RA, Borrie M, Guzman D, et al. Anatomically-distinct genetic associations of Apoe e4 allele load with regional cortical atrophy in Alzheimer's disease . Neuroimage . 2009;44:724–728
  13. Folstein MF , Folstein SE , McHugh PR . “Mini-mental state” (A practical method for grading the cognitive state of patients for the clinician) . J. Psychiatr. Res. . 1975;12:189–198
  14. Geroldi C, Pihlajamaki M, Laakso MP, deCarli C, Beltramello A, Bianchetti A, et al. APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD . Neurology . 1999;53:1825–1832
  15. Good CD , Johnsrude IS , Ashburner J , Henson RN , Friston KJ , Frackowiak RS . A voxel-based morphometric study of ageing in 465 normal adult human brains . Neuroimage . 2001;14:21–36
  16. Hashimoto M, Yasuda M, Tanimukai S, Matsui M, Hirono N, Kazui H, et al. Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease . Neurology . 2001;57:1461–1466
  17. Hayasaka S , Phan KL , Liberzon I , Worsley KJ , Nichols TE . Nonstationary cluster- size inference with random field and permutation methods . Neuroimage . 2004;22:676–687
  18. Holmans P, Hamshere M, Hollingworth P, Rice F, Tunstall N, Jones S, et al. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 2005;135B:24–32
  19. Hu Z , Zeng L , Huang Z , Zhang J , Li T . The study of golgi apparatus in alzheimer's disease . Neurochem. Res. . 2007;32:1265–1277
  20. Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, et al. Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder . Arch. Gen. Psychiatry . 2009;66:721–728
  21. Ioannidis JP , Trikalinos TA , Khoury MJ . Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases . Am. J. Epidemiol. . 2006;164:609–614
  22. Jack CR, Petersen RC, Xu Y, O'Brien PC, Smith GE, Ivnik RJ, et al. Rates of hippocampal atrophy correlate with change in clinical status in aging and AD . Neurology . 2000;55:484–489
  23. Judas M , Cepanec M . Adult structure and development of the human fronto-opercular cerebral cortex (Broca's region) . Clin. Linguist. Phon. . 2007;21:975–989
  24. Kladney RD, Bulla GA, Guo L, Mason AL, Tollefson AE, Simon DJ, et al. GP73, a novel Golgi-localized protein upregulated by viral infection . Gene . 2000;249:53–65
  25. Lee JH, Cheng R, Santana V, Williamson J, Lantigua R, Medrano M, et al. Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease . Arch. Neurol. . 2006;63:1591–1598
  26. Lehtovirta M, Laakso MP, Soininen H, Helisalmi S, Mannermaa A, Helkala EL, et al  Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes . Neuroscience . 1995;67:65–72
  27. Lehtovirta M, Soininen H, Laakso MP, Partanen K, Helisalmi S, Mannermaa A, et al. SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele . J. Neurol. Neurosurg. Psychiatry . 1996;60:644–649
  28. Li H, Wetten S, Li L, St. Jean PL, Upmanyu R, Surh L, et al. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease . Arch. Neurol. . 2008;65:45–53
  29. McDonalds CR, McEvoy LK, Gharapetian L, Fennema-Notestine C, Hagler DJ, Holland D, et al. Regional rates of neocortical atrophy from normal aging to Alzheimer's disease . Neurology . 2009;73:457–465
  30. McKhann G , Drachman D , Folstein M , Katzman R , Price D , Stadlan EM . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease . Neurology . 1984;34:939–944
  31. Mudge J, Miller NA, Khrebtukova I, Lindquist IE, May GD, Huntley JJ, et al. Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum . PLoS One . 2008;3:e3625
  32. Muglia P, Tozzi F, Galwey NW, Francks C, Upmanyu R, Kong XQ, et al. Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts . Mol. Psychiatry . 2008; in press. PMID: 19107115
  33. Myers A, Wavrant De-Vrieze F, Holmans P, Hamshere M, Crook R, Compton D, et al. Full genome screen for Alzheimer disease: stage II analysis . Am. J. Med. Genet. . 2002;114:235–244
  34. Nichols T , Hayasaka S . Controlling the familywise error rate in functional neuroimaging: a comparative review . Stat. Methods Med. Res. . 2003;12:419–446
  35. Olson JM , Goddard KA , Dudek DM . A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region . Am. J. Hum. Genet. . 2002;71:154–161
  36. Pericak-Vance MA, Grubber J, Bailey LR, Hedges D, West S, Santoro L, et al. Identification of novel genes in late-onset Alzheimer's disease . Exp. Gerontol. . 2000;35:1343–1352
  37. Puri S , Bachert C , Fimmel CJ , Linstedt AD . Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption . Traffic . 2002;3:641–653
  38. Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, et al. GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results . Arch. Neurol. . 2009;66:250–254
  39. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, et al. A gene atlas of the mouse and human protein-encoding transcriptomes . Proc. Natl. Acad. Sci. U. S. A. . 2004;101:6062–6067
  40. Tanaka S, Kawamata J, Shimohama S, Akaki H, Akiguchi I, Kimura J, et al. Inferior temporal lobe atrophy and APOE genotypes in Alzheimer's disease (X-ray computed tomography, magnetic resonance imaging and Xe-133 SPECT studies) . Dement. Geriatr. Cogn. Disord. . 1998;9:90–98
  41. Thompson PM, Hayashi KM, Dutton RA, Chiang MC, Leow AD, Sowell ER, et al. Tracking Alzheimer's disease . Ann. N.Y. Acad. Sci. . 2007;1097:183–214
  42. Tozzi F, Prokopenko I, Perry JD, Kennedy JL, McCarthy AD, Holsboer F, et al. Family history of depression is associated with younger age of onset in patients with recurrent depression . Psychol. Med. . 2008;38:641–649
  43. Tzourio-Mazoyer N, Landbeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain . Neuroimage . 2002;15:273–289

PII: S0197-4580(10)00183-1

doi: 10.1016/j.neurobiolaging.2010.04.018

Neurobiology of Aging
Volume 33, Issue 3 , Pages 457-465 , March 2012