Neurobiology of Aging
Volume 33, Issue 3 , Pages 466-478 , March 2012

Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease

  • Walter Koch

      Affiliations

    • Institute for Clinical Radiology, University of Munich, Munich, Germany
    • Corresponding Author InformationCorresponding author at: Institute for Clinical Radiology, University of Munich, Marchioninistr. 15, 81377 Munich, Germany. Tel.: +49 89 7095 3620
    • ,
  • Stephan Teipel

      Affiliations

    • Department of Psychiatry, University of Rostock, Rostock, Germany
    • Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Germany
    • ,
  • Sophia Mueller

      Affiliations

    • Institute for Clinical Radiology, University of Munich, Munich, Germany
    • ,
  • Jens Benninghoff

      Affiliations

    • Department of Psychiatry & Alzheimer Memorial Center, University of Munich, Munich, Germany
    • ,
  • Maxmilian Wagner

      Affiliations

    • Department of Psychiatry & Alzheimer Memorial Center, University of Munich, Munich, Germany
    • ,
  • Arun L.W. Bokde

      Affiliations

    • Department of Psychiatry & Alzheimer Memorial Center, University of Munich, Munich, Germany
    • Discipline of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland
    • Trinity College Institute of Neuroscience (TCIN), Laboratory of Neuroimaging & Biomarker Research, Trinity College, Dublin, Ireland
    • The Adelaide and Meath Hospital Incorporating the National Children's Hospital (AMiNCH), Dublin, Ireland
    • ,
  • Harald Hampel

      Affiliations

    • Department of Psychiatry & Alzheimer Memorial Center, University of Munich, Munich, Germany
    • Discipline of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland
    • Trinity College Institute of Neuroscience (TCIN), Laboratory of Neuroimaging & Biomarker Research, Trinity College, Dublin, Ireland
    • The Adelaide and Meath Hospital Incorporating the National Children's Hospital (AMiNCH), Dublin, Ireland
    • ,
  • Ute Coates

      Affiliations

    • Institute for Clinical Radiology, University of Munich, Munich, Germany
    • ,
  • Maximilian Reiser

      Affiliations

    • Institute for Clinical Radiology, University of Munich, Munich, Germany
    • ,
  • Thomas Meindl

      Affiliations

    • Institute for Clinical Radiology, University of Munich, Munich, Germany

Received 3 November 2009 ,Revised 7 April 2010 ,Accepted 13 April 2010.

References 

  1. Artero S , Tierney MC , Touchon J , Ritchie K . Prediction of transition from cognitive impairment to senile dementia: a prospective, longitudinal study . Acta Psychiatr. Scand . 2003;107:390–393
  2. Beckmann CF , Smith SM . Tensorial extensions of independent component analysis for multisubject FMRI analysis . Neuroimage . 2005;25:294–311
  3. Benjamini Y , Hochberg Y . Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing . J. R. Stat. Soc. B . 1995;57:289–300
  4. Binder JR , Frost JA , Hammeke TA , Bellgowan PS , Rao SM , Cox RW . Conceptual processing during the conscious resting state (A functional MRI study) . J. Cogn. Neurosci . 1999;11:80–95
  5. Birn RM , Diamond JB , Smith MA , Bandettini PA . Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI . Neuroimage . 2006;31:1536–1548
  6. Bluhm RL, Osuch EA, Lanius RA, Boksman K, Neufeld RW, Theberge J, et al. Default mode network connectivity: effects of age, sex, and analytic approach . Neuroreport . 2008;19:887–891
  7. Braak H , Braak E . Neuropathological staging of Alzheimer-related changes . Acta Neuropathol . 1991;82:239–259
  8. Buckner RL, Snyder AZ, Shannon BJ, laRossa G, Sachs R, Fotenos AF, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory . J. Neurosci . 2005;25:7709–7717
  9. Buerger K, Ewers M, Andreasen N, Zinkowski R, Ishiguro K, Vanmechelen E, et al. Phosphorylated tau predicts rate of cognitive decline in MCI subjects: a comparative CSF study . Neurology . 2005;65:1502–1503
  10. Conde JR , Streit WJ . Microglia in the aging brain . J. Neuropathol. Exp. Neurol . 2006;65:199–203
  11. Damoiseaux JS, Beckmann CF, Arigita EJ, Barkhof F, Scheltens P, Stam CJ, et al. Reduced resting-state brain activity in the “default network” in normal aging . Cereb. Cortex . 2008;18:1856–1864
  12. Damoiseaux JS, Rombouts SA, Barkhof F, Scheltens P, Stam CJ, Smith SM, et al. Consistent resting-state networks across healthy subjects . Proc. Natl. Acad. Sci. U. S. A. . 2006;103:13848–13853
  13. De Luca M , Beckmann CF , De Stefano N , Matthews PM , Smith SM . fMRI resting state networks define distinct modes of long-distance interactions in the human brain . Neuroimage . 2006;29:1359–1367
  14. De Santi S, de Leon MJ, Convit A, Tarshish C, Rusinek H, Tsui WH, et al. Age-related changes in brain: II (Positron emission tomography of frontal and temporal lobe glucose metabolism in normal subjects) . Psychiatr. Q. . 1995;66:357–370
  15. Delbeuck X , Van der Linden M , Collette F . Alzheimer's disease as a disconnection syndrome? . Neuropsychol. Rev . 2003;13:79–92
  16. Drzezga A, Grimmer T, Riemenschneider M, Lautenschlager N, Siebner H, Alexopoulus P, et al. Prediction of individual clinical outcome in MCI by means of genetic assessment and (eighteen) F-FDG PET . J. Nucl. Med . 2005;46:1625–1632
  17. Drzezga A, Lautenschlager N, Siebner H, Riemenschneider M, Willoch F, Minoshima S, et al. Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study . Eur. J. Nucl. Med. Mol. Imaging . 2003;30:1104–1113
  18. Esposito F, Bertolino A, Scarabino T, Latorre V, Blasi G, Popolizio T, et al. Independent component model of the default-mode brain function: Assessing the impact of active thinking . Brain Res. Bull . 2006;70:263–269
  19. Esposito F, Scarabino T, Hyvarinen A, Himberg J, Formisano E, Comani S, et al. Independent component analysis of fMRI group studies by self-organizing clustering . Neuroimage . 2005;25:193–205
  20. Fox MD , Snyder AZ , Vincent JL , Corbetta M , Van Essen DC , Raichle ME . The human brain is intrinsically organized into dynamic, anticorrelated functional networks . Proc. Natl. Acad. Sci. U. S. A. . 2005;102:9673–9678
  21. Fransson P . Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis . Hum. Brain Mapp . 2005;26:15–29
  22. Fukunaga M, Horovitz SG, van Gelderen P, de Zwart JA, Jansma JM, Ikonomidou VN, et al. Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages . Magn. Reson. Imaging . 2006;24:979–992
  23. Garrity AG , Pearlson GD , McKiernan K , Lloyd D , Kiehl KA , Calhoun VD . Aberrant “default mode” functional connectivity in schizophrenia . Am. J. Psychiatry . 2007;164:450–457
  24. Goebel R , Esposito F , Formisano E . Analysis of functional image analysis contest (FIAC) data with brainvoyager QX: From single-subject to cortically aligned group general linear model analysis and self-organizing group independent component analysis . Hum. Brain Mapp . 2006;27:392–401
  25. Good CD , Johnsrude IS , Ashburner J , Henson RN , Friston KJ , Frackowiak RS . A voxel-based morphometric study of ageing in 465 normal adult human brains . Neuroimage . 2001;14:21–36
  26. Grady CL , Furey ML , Pietrini P , Horwitz B , Rapoport SI . Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease . Brain . 2001;124:739–756
  27. Greicius MD, Flores BH, Menon V, Glover GH, Solvason HB, Kenna H, et al. Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus . Biol. Psychiatry . 2007;62:429–437
  28. Greicius MD , Srivastava G , Reiss AL , Menon V . Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI . Proc. Natl. Acad. Sci. U. S. A. . 2004;101:4637–4642
  29. Hedges LV , Vevea JL . Fixed- and random-effects models in meta-analysis . Psychol. Methods . 1998;3:486–504
  30. Horwitz B , Grady CL , Schlageter NL , Duara R , Rapoport SI . Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease . Brain Res . 1987;407:294–306
  31. Knopman DS, deKosky ST, Cummings JL, Chui H, Corey-Bloom J, Relkin N, et al. Practice parameter: diagnosis of dementia (an evidence-based review) (Report of the Quality Standards Subcommittee of the American Academy of Neurology) . Neurology . 2001;56:1143–1153
  32. Koch W, Teipel S, Mueller S, Buerger K, Bokde AL, Hampel H, et al. Effects of aging on default mode network activity in resting state fMRI: Does the method of analysis matter? . Neuroimage . 2010;51:280–287
  33. McKeown MJ, Makeig S, Brown GG, Jung TP, Kindermann SS, Bell AJ, et al. Analysis of fMRI data by blind separation into independent spatial components . Hum. Brain Mapp . 1998;6:160–188
  34. McKhann GM , Albert MS , Grossman M , Miller B , Dickson D , Trojanowski JQ . Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease . Arch. Neurol . 2001;58:1803–1809
  35. Minoshima S , Giordani B , Berent S , Frey KA , Foster NL , Kuhl DE . Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease . Ann. Neurol . 1997;42:85–94
  36. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) (Part I. Clinical and neuropsychological assessment of Alzheimer's disease) . Neurology . 1989;39:1159–1165
  37. Mosconi L . Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease (FDG-PET studies in MCI and AD) . Eur. J. Nucl. Med. Mol. Imaging . 2005;32:486–510
  38. Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias . J. Nucl. Med . 2008;49:390–398
  39. Mosconi L, Tsui WH, Pupi A, De Santi S, Drzezga A, Minoshima S, et al. (eighteen) F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's disease . J. Nucl. Med . 2007;48:1129–1134
  40. Nordberg A . Is amyloid plaque imaging the key to monitoring brain pathology of Alzheimer's disease in vivo? . Eur J. Nucl. Med. Mol. Imaging . 2004;31:1540–1543
  41. Nordberg A . Amyloid plaque imaging in vivo: current achievement and future prospects . Eur. J. Nucl. Med. Mol. Imaging . 2008;35(suppl 1):S46–S50
  42. Oldfield RC . The assessment and analysis of handedness: the Edinburgh inventory . Neuropsychologia . 1971;9:97–113
  43. Petersen RC . Mild cognitive impairment as a diagnostic entity . J. Intern. Med . 2004;256:183–194
  44. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, et al. Current concepts in mild cognitive impairment . Arch. Neurol . 2001;58:1985–1992
  45. Petersen RC, Smith GE, Ivnik RJ, Tangalos EG, Schaid DJ, Thibodeau SN, et al. Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals . JAMA . 1995;273:1274–1278
  46. Phelps ME , Schelbert HR , Mazziotta JC . Positron computed tomography for studies of myocardial and cerebral function . Ann. Intern. Med . 1983;98:339–359
  47. Raz N, Gunning FM, Head D, Dupuis JH, McQuain J, Briggs SD, et al. Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter . Cereb. Cortex . 1997;7:268–282
  48. Rombouts SA, Damoiseaux JS, Goekoop R, Barkhof F, Scheltens P, Smith SM, et al. Model-free group analysis shows altered BOLD FMRI networks in dementia . Hum. Brain Mapp . 2009;30:256–266
  49. Shulman GL, Corbetta M, Buckner RL, Raichle ME, Fiez JA, Miezin FM, et al. Top-down modulation of early sensory cortex . Cereb. Cortex . 1997;7:193–206
  50. Sorg C, Riedl V, Muhlau M, Calhoun VD, Eichele T, Laer L, et al. Selective changes of resting-state networks in individuals at risk for Alzheimer's disease . Proc. Natl. Acad. Sci. U. S. A. . 2007;104:18760–18765
  51. Talairach JTP . Co-Planar Stereotaxic Atlas of the Human Brain . New York: Thieme; 1988;
  52. Tierney MC, Szalai JP, Snow WG, Fisher RH, Nores A, Nadon G, et al. Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study . Neurology . 1996;46:661–665
  53. Tierney MC, Szalai JP, Snow WG, Fisher RH, Tsuda T, Chi H, et al. A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment . Neurology . 1996;46:149–154
  54. Wang K, Liang M, Wang L, Tian L, Zhang X, Li K, et al. Altered functional connectivity in early Alzheimer's disease: a resting-state fMRI study . Hum. Brain Mapp . 2007;28:967–978
  55. Wang L, Zang Y, He Y, Liang M, Zhang X, Tian L, et al. Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI . Neuroimage . 2006;31:496–504
  56. Whitwell JL , Jack CR . Comparisons between Alzheimer disease, frontotemporal lobar degeneration, and normal aging with brain mapping . Top. Magn. Reson. Imaging . 2005;16:409–425
  57. Willis MW, Ketter TA, Kimbrell TA, George MS, Herscovitch P, Danielson AL, et al. Age, sex and laterality effects on cerebral glucose metabolism in healthy adults . Psychiatry Res. . 2002;114:23–37

PII: S0197-4580(10)00178-8

doi: 10.1016/j.neurobiolaging.2010.04.013

Neurobiology of Aging
Volume 33, Issue 3 , Pages 466-478 , March 2012

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