« Previous
Next »
Neurobiology of Aging
Volume 32, Issue 8
, Pages 1495-1504
, August 2011
Reduced serine racemase expression contributes to age-related deficits in hippocampal cognitive function
References
- . Hippocampal dependent learning ability correlates with N-methyl-d-aspartate (NMDA) receptor levels in CA3 neurons of young and aged rats. J. Comp. Neurol. 2001;432:230–243
- . The LOU/c/jall rat as an animal model of healthy aging?. J. Gerontol. A Biol. Sci. Med. Sci. 2002;57:B312–320
- . Tetrahydroaminoacridine and d-cycloserine stimulate acquisition of water maze spatial navigation in aged rats. Eur. J. Pharmacol. 1998;342:15–20
- . Pre-training blocks the improving effect of tetrahydroaminoacridine and d-cycloserine on spatial navigation performance in aged rats. Eur. J. Pharmacol. 2000;390:313–318
- . An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses. Behav. Neurosci. 1985;99:1040–1048
- . Involvement of LTP in memory: are we “searching under the street light”?. Neuron. 1995;15:751–754
- . Age-related decrease in the N-methyl-d-aspartateR-mediated excitatory postsynaptic potential in hippocampal region CA1. Neurobiol. Aging. 1997;18:445–452
- . Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol. Psychiatry. 2009;14:719–727
- . d-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats. Neurobiol. Aging. 1994;15:207–213
- . Ageing, hippocampal synaptic activity and magnesium. Magnes. Res. 2006;19:199–215
- . d-serine signalling as a prominent determinant of neuronal-glial dialogue in the healthy and diseased brain. J. Cell Mol. Med. 2008;12:1872–1884
- . Age-related deficits as working memory load increases: relationships with growth factors. Neurobiol. Aging. 2003;24:37–48
- . Protein kinase C activity is associated with prefrontal cortical decline in aging. Neurobiol. Aging. 2009;30:782–792
- . Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 2002;99:13675–13680
- . A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat. J. Neurosci. 2002;22:3628–3637
- . Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell. 2007;6:361–370
- . Serine racemase expression and d-serine content are developmentally regulated in neuronal ganglion cells of the retina. J. Neurochem. 2008;104:970–978
- . Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiol. Aging. 2007;28:424–439
- . Caloric restriction prevents age-related deficits in LTP and in NMDA receptor expression. Brain Res. Mol. Brain Res. 2000;78:154–162
- . Learning from LTP: a comment on recent attempts to identify cellular and molecular mechanisms of memory. Learn. Mem. 1996;3:61–73
- . Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc. Natl. Acad. Sci. U.S.A. 1996;93:4765–4769
- . Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell. 2007;6:319–325
- . Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidative defense systems. Ann. N.Y. Acad. Sci. 2001;928:168–175
- . Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release. J. Neurosci. 2006;26:3482–3490
- . Fat intake reverses the beneficial effects of low caloric intake on skeletal muscle mitochondrial H(2)O(2) production. Free Radic. Biol. Med. 2005;39:1249–1261
- . d-amino-acid oxidase is confined to the lower brain stem and cerebellum in rat brain: regional differentiation of astrocytes. Brain Res. 1994;652:297–303
- . Role of NMDA receptors in memory. Trends Pharmacol. Sci. 1991;12:128–129
- . Age-related effects of the neuromodulator d-serine on neurotransmission and synaptic potentiation in the CA1 hippocampal area of the rat. J. Neurochem. 2006;98:1159–1166
- . Preserved memory capacities in aged Lou/C/Jall rats. Neurobiol. Aging. 2008;
- . Intracellular calcium stores contribute to increased susceptibility to LTD induction during aging. Brain Res. 2005;1031:125–128
- . Impaired monosynaptic potentiation in in vitro hippocampal slices from aged, memory-deficient rats. J. Gerontol. 1977;32:523–533
- . The effects of high Mg2+-to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats. J. Neurophysiol. 1986;56:797–811
- . Synaptic plasticity: a molecular memory switch. Curr. Biol. 2001;11:R788–791
- . Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc. Natl. Acad. Sci. U.S.A. 2003;100:8526–8531
- . Memory and the brain: unexpected chemistries and a new pharmacology. Neurobiol. Learn. Mem. 1998;70:82–100
- . Age-related changes in the protein expression of subunits of the NMDA receptor. Brain Res. Mol. Brain Res. 2002;99:40–45
- . Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study. Neurobiol. Aging. 2007;28:1556–1567
- . d-serine signalling in the brain: friend and foe. Trends Neurosci. 2006;29:481–491
- . Age-related changes in LTP and antioxidant defenses are reversed by an alpha-lipoic acid-enriched diet. Neurobiol. Aging. 1999;20:655–664
- . Serine racemase is predominantly localized in neurons in mouse brain. J. Comp. Neurol. 2008;510:641–654
- . Impairment in abstraction and set shifting in aged rhesus monkeys. Neurobiol. Aging. 2003;24:125–134
- . d-serine is an endogenous ligand for the glycine site of the N-methyl-d-aspartate receptor. Proc. Natl. Acad. Sci. U.S.A. 2000;97:4926–4931
- . A critical role for the glial-derived neuromodulator d-serine in the age-related deficits of cellular mechanisms of learning and memory. Aging Cell. 2006;5:267–274
- . Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of d-serine formation. Proc. Natl. Acad. Sci. U.S.A. 2007;104:2950–2955
- . Prefrontal alterations during memory processing in aging. Cereb. Cortex. 1995;5:541–549
- . Molecular determinants of d-serine-mediated gliotransmission: from release to function. Glia. 2006;54:726–737
- . Decline in motor functions in aging is related to the loss of NMDA receptors. Brain Res. 2001;907:71–83
- . Glia-derived d-serine controls NMDA receptor activity and synaptic memory. Cell. 2006;125:775–784
- . Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats. Neuroscience. 2007;146:1719–1725
- . NMDA receptor activation in the aged rat hippocampus. Exp. Gerontol. 2000;35:1185–1199
- . Calcium-binding proteins map the postnatal development of rat vestibular nuclei and their vestibular and cerebellar projections. J. Comp. Neurol. 2002;451:374–391
- . Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cereb. Cortex. 1997;7:268–282
- . Isolating the neural mechanisms of age-related changes in human working memory. Nat. Neurosci. 2000;3:509–515
- . d-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors. J. Neurosci. 1997;17:1604–1615
- . d-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc. Natl. Acad. Sci. U.S.A. 1995;92:3948–3952
- . Aging differentially alters forms of long-term potentiation in rat hippocampal area CA1. J. Neurophysiol. 1998;79:334–341
- . d-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices. J. Neurosci. 2005;25:9413–9417
- . Oxidative stress, caloric restriction, and aging. Science. 1996;273:59–63
- . Learning deficits in aged rats related to decrease in extracellular volume and loss of diffusion anisotropy in hippocampus. Hippocampus. 2002;12:269–279
- . Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell. 2007;6:307–317
- . Age-and dose-dependent facilitation of associative eyeblink conditioning by d-cycloserine in rabbits. Behav. Neurosci. 1997;111:1303–1312
- . Hippocampus-dependent learning facilitated by a monoclonal antibody or d-cycloserine. Nature. 1992;359:638–641
- . Gene expression of d-amino acid oxidase in cultured rat astrocytes: regional and cell type specific expression. Neurosci. Lett. 2002;324:101–104
- . Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice. Learn. Mem. 2004;11:253–260
- . NMDA receptor regulation by d-serine: new findings and perspectives. Mol. Neurobiol. 2007;36:152–164
- . Serine racemase: a glial enzyme synthesizing d-serine to regulate glutamate-N-methyl-d-aspartate neurotransmission. Proc. Natl. Acad. Sci. U.S.A. 1999;96:13409–13414
- . Age-related decline in water maze learning and memory in rats: strain differences. Neurobiol. Aging. 2000;21:671–681
- . Contribution of astrocytes to hippocampal long-term potentiation through release of d-serine. Proc. Natl. Acad. Sci. U.S.A. 2003;100:15194–15199
- . Immunohistochemical evidences for localization and production of d-serine in some neurons in the rat brain. Neurosci. Lett. 2001;299:162–164
PII: S0197-4580(09)00304-2
doi: 10.1016/j.neurobiolaging.2009.09.001
« Previous
Next »
Neurobiology of Aging
Volume 32, Issue 8
, Pages 1495-1504
, August 2011
