Neurobiology of Aging
Volume 30, Issue 10 , Pages 1523-1534 , October 2009

Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide

Received 14 May 2009 ,Revised 1 June 2009 ,Accepted 5 June 2009.

References 

  1. Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J. Neurosci. 1996;16:1066–1071
  2. Bonnefoy M, Drai J, Kosika T. Antioxidants to delay the process of aging: facts and figures. Presse Medicale. 2002;31:1174–1184
  3. Butterfield DA, Perluigi M, Sultana R. Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics. Eur. J. Pharmacol. 2006;545:39–50
  4. Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, et al. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochem. Res. 2008;33:2444–2471
  5. Danielson K, Andersen JK. Oxidative and nitrative protein modifications in Parkinson's disease. Free Radic. Biol. Med. 2008;44:1787–1794
  6. Enokido Y, Suzuki E, Iwasawa K, Kazuhiko N, Okazawa H, Kimura H. Cystathionine B-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS. FASEB J. 2005;19:1854–1856
  7. Eto K, Ogasawara K, Umemura Y, Nagai Y, Kimura H. Hydrogen sulfide is produced in response to neuronal stimulation. J. Neurosci. 2002;22:3386–3391
  8. Hashioka S, Klegeris A, Schwab C, McGeer PL. Interferon—dependent cytotoxic activation of human astrocytes and astrocytoma cells. Neurobiol. Aging. 2008;
  9. Hosoki R, Matsuki N, Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem. Biophys. Res. Commun. 1997;237:527–531
  10. Ichinohe A, Kanaumi T, Takashima S, Enokido Y, Nagai Y, Kimura H. Cystathionine B-synthase is enriched in the brains of Down's patients. Biochem. Biophys. Res. Commun. 2005;338:1547–1550
  11. Kamoun P. Endogenous production of hydrogen sulfide in mammals. Amino Acids. 2004;26:243–254
  12. Kimura H. Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. Biochem. Biophys. Res. Commun. 2000;267:129–133
  13. Kimura H. Hydrogen sulfide as a neuromodulator. Mol. Neurobiol. 2002;26:13–19
  14. Klegeris A, Giasson BI, Zhang H, Maguire J, Pelech S, McGeer PL. Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells. FASEB J. 2006;20:2000–2008
  15. Klegeris A, Walker DG, McGeer PL. Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs). Neuropharmacology. 1999;38:1017–1025
  16. Klegeris A, Bissonnette CJ, McGeer PL. Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system. Neurobiol. Aging. 2005;26:673–682
  17. Lee M, Lee SJ, Choi HJ, Jung YW, Frokiaer J, Nielsen S, et al. Regulation of AQP4 protein expression in rat brain astrocytes: role of P2X7 receptor activation. Brain Res. 2008;1195:1–11
  18. Lee, M., Sparatore, A., Soldato, P., McGeer, E.G., McGeer, P.L., 2009. Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation. Glia, in press, doi:10.1002/glia.20905.
  19. Li L, Bhatia M, Zhu Y, Zhu YC, Ramath RD, Wang ZJ, et al. Hydrogen sulfide is a novel mediator of endotoxic shock. FASEB J. 2005;19:1196–1198
  20. Li L, Rossoni G, Sparatore A, Lee LC, Del Soldato P, Moore PK. Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative. Free Radic. Biol. Med. 2007;42:706–719
  21. Lowicka E, Beltowski J. Hydrogen sulfide (H2S)—the third gas of interest for pharmacologists. Pharmacol. Rep. 2007;59:4–24
  22. Mudd SH, Skovby F, Levy HL, Pettigrew KD, Wilcken B, Pyeritz RE, et al. The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am. J. Hum. Genet. 1985;37:1–31
  23. Pratico D. Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy. Ann. N. Y. Acad. Sci. 2008;1147:70–78
  24. Qu K, Lee SW, Bian JS, Low CM, Wong PT. Hydrogen sulfide: neurochemistry and neurobiology. Neurochem. Int. 2008;52:155–165
  25. Rossoni G, Sparatore A, Tazzari V, Manfredi B, Del Soldato P, Berti F. The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia reperfusion injury in the isolated rabbit heart. Br. J. Pharmacol. 2008;153:100–109
  26. Sakurai H, Chiba H. IkB kinases phosphorylate NF-kB p65 subunit on serine 536 in the transactivation domain. J. Biol. Chem. 1999;274:30353–30356
  27. Sayre M, Smith MA, Perry G. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr. Med. Chem. 2001;8:721–738
  28. Sun B, Zou X, Yueling C, Zhang P, Shi G. Precondtioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVEC. Int. J. Biol. Sci. 2008;4:270–278
  29. Szabo C. Hydrogen sulphide and its therapeutic potential. Nat. Rev. Drug Discov. 2007;6:917–935
  30. Warenycia MW, Goodwin LR, Benishin CG, Reiffenstein RJ, Francom DM, Taylor JD, et al. Acute hydrogen sulfide poisoning. Demonstration of selective uptake of sulfide by the brainstem by measurement of brain sulfide levels. Biochem. Pharmacol. 1989;38:973–981
  31. Webb GD, Lim LH, Oh VMS, Yeo SB, Cheong YP, Ali MY, et al. Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human mammary artery. J. Pharmacol. Exp. Ther. 2008;324:876–882
  32. Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, et al. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008;322:587–590
  33. Zhao W, Zhang J, Lu Y, Wang R. The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J. 2001;20:6008–6016

PII: S0197-4580(09)00205-X

doi: 10.1016/j.neurobiolaging.2009.06.001

Neurobiology of Aging
Volume 30, Issue 10 , Pages 1523-1534 , October 2009