Neurobiology of Aging
Volume 30, Issue 4 , Pages 515-520 , April 2009

The neurobiology of middle-age has arrived

Received 13 October 2008 ,Accepted 6 November 2008.

References 

  1. Amano T, Meyer JS, Okabe T, Shaw T, Mortel KF. Stable xenon CT cerebral blood flow measurements computed by a single compartment-double integration model in normal aging and dementia. J. Comput. Assist. Tomogr. 1982;6:23–932
  2. Arnsten AF, Cai JX, Steere JC, Goldman-Rakic PS. Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys. J. Neurosci. 1995;5:3429–3439
  3. Bartzokis G, Lu PH, Geschwind DH, Huang D, Mendez MF, Edwards N, et al. Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia. Biol. Psychiatry. 2007;62:1380–1387
  4. Calderón-Garcidueñas L, Mora-Tiscareno A, Ontiveros E, Gomez-Garza G, Barraqan-Mejia G, Broadway J, et al. Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs. Brain Cogn. 2008;68:117–127
  5. Calderón-Garcidueñas L, Villarreal-Calderon R, Valencia-Salazar G, Henríquez-Roldán C, Gutiérrez-Castrellón P, Torres-Jardón R, et al. Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutants. Inhal. Toxicol. 2008;20:499–506
  6. Coleman P, Finch CE, Joseph J. The need for multiple time points in aging studies (editorial). Neurobiol. Aging. 1990;11:1–2
  7. D’Armiento FP, Bianchi A, de Nigris F, Capuzzi DM, D’Armiento MR, Crimi G, et al. Age-related effects on atherogenesis and scavenger enzymes of intracranial and extracranial arteries in men without classic risk factors for atherosclerosis. Stroke. 2001;32:2472–2479
  8. Dreher JC, Meyer-Lindenberg A, Kohn P, Berman KF. Age related changes in midbrain dopaminergic regulation of the human reward system. Proc. Natl. Acad. Sci. U. S. A. 2009;106:617–622
  9. Finch CE. Middle-age: an evolving frontier in gerontology (editorial). Neurobiol. Aging. 1991;12:1–2
  10. Finch CE. The brain as a site for cellular pacemakers of aging. In: Ninth International Congress on Gerontology. Kiev USSR. 1972;p. 100–101
  11. Finch CE. Catecholamine metabolism in the brains of ageing male mice. Brain Res. 1973;52:261–276
  12. Finch CE. Developmental origins of aging in brain and blood vessels: an overview. Neurobiol. Aging. 2005;26:281–291
  13. Finch CE. The Biology of Human Longevity. Inflammation, Nutrition and Aging in the Evolution of Lifespans. San Diego: Academic Press; 2007;
  14. Finkel D, Reynolds CA, McArdle JJ, Pedersen NL. Cohort differences in trajectories of cognitive aging. J. Gerontol. B: Psychol. Sci. Soc. Sci. 2007;62:286–294
  15. Hansen LA, Armstrong DM, Terry RD. An immunohistochemical quantification of fibrous astrocytes in the aging human cerebral cortex. Neurobiol. Aging. 1987;8:1–6
  16. Jonec V, Finch CE. Ageing and dopamine uptake by subcellular fractions of the C57BL/6J male mouse brain. Brain Res. 1975;91:197–215
  17. Landau SM, Lal R, O’Neil JP, Baker S, Jagust WJ. Striatal dopamine and working memory. Cereb Cortex. 2009;19:445–454
  18. Levin P, Janda JK, Joseph JA, Ingram DK, Roth GS. Dietary restriction retards the age-associated loss of rat striatal dopaminergic receptors. Science. 1981;214:561–562
  19. Li KZ, Lindenberger U, Freund AM, Baltes PB. Walking while memorizing: age-related differences in compensatory behavior. Psychol. Sci. 2001;12:230–237
  20. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Prospective studies collaboration age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903–1913
  21. Lyketsos CG, Chen LS, Anthony JC. Cognitive decline in adulthood: an 11 5-year follow-up of the Baltimore Epidemiologic Catchment Area Study. Am. J. Psychiatry. 1999;156:58–65
  22. Marcusson JO, Morgan DG, Winblad B, Finch CE. Serotonin-2 binding sites in human frontal cortex and hippocampus: selective loss of S-2A sites with age. Brain Res. 1984;311:51–56
  23. Marshall JF, Berrios N. Movement disorders of aged rats: reversal by dopamine receptor stimulation. Science. 1979;206:477–479
  24. Masliah E, Mallory M, Hansen L, DeTeresa R, Terry RD. Quantitative synaptic alterations in the human neocortex during normal aging. Neurology. 1993;43:192–197
  25. McArdle JJ, Ferrer-Caja E, Hamagami F, Woodcock RW. Comparative longitudinal structural analyses of the growth and decline of multiple intellectual abilities over the life span. Dev. Psychol. 2002;38:115–142
  26. McArdle JJ, Fisher GG, Kadlec KM. Latent variable analysis of age trends in tests of cognitive ability in the health and retirement survey 1992–2004. Psychol. Aging. 2007;22:525–545
  27. McArdle JJ. Latent variable modeling of differences and changes with longitudinal data. Ann. Rev. Psychol. 2009;60:577–605
  28. Morgan DG, Marcusson JO, Nyberg P, Wester P, Winblad BN, Gordon MN, et al. Divergent changes in D-1 and D-2 dopamine binding sites of human brain during aging. Neurobiol. Aging. 1987;8:195–201
  29. Morgan DG, May PC, Finch CE. Dopamine and serotonin systems in human and rodent brain: effects of age and degenerative disease. J. Am. Geriatr. Soc. 1987;35:334–345
  30. Morgan TE, Xie Z, Goldsmith S, Yoshida T, Lanzrein AS, Stone D, et al. The mosaic of brain glial hyperactivity during normal aging and its attenuation by food restriction. Neuroscience. 1999;89:687–699
  31. Roth GS, Ingram DK, Joseph JA. Delayed loss of striatal dopamine receptors during aging of dietarily restricted rats. Brain Res. 1984;300:27–32
  32. Rozovsky I, Wei M, Morgan TE, Finch CE. Reversible age impairments in neurite outgrowth by manipulations of astrocytic GFAP. Neurobiol. Aging. 2005;26:705–715
  33. Salthouse T. When does age-related cognitive decline begin?. Neurobiol. Aging. 2009;30(2009):530–533
  34. Severson JA, Finch CE. Reduced dopaminergic binding during aging in the rodent striatum. Brain Res. 1980;192:147–162
  35. Severson JA, Marcusson J, Winbald B, Finch CE. Age-correlated loss of dopaminergic binding sites in human basal ganglia. J. Neurochem. 1982;39:1623–1631
  36. Severson JA, Marcusson JO, Osterburg HH, Finch CE, Winblad B. Elevated density of [3H]Imipramine binding in aged human brain. J. Neurochem. 1985;45:1382–1389
  37. Severson JA, Pittman RN, Gal J, Molinoff PB, Finch CE. Genetic influence on the regulation of beta-adrenergic receptors in mice. J. Pharm. Exp. Ther. 1986;236:24–29
  38. Severson JA, Randall PK, Finch CE. Genotypic influences on striatal dopaminergic regulation in mice. Brain Res. 1981;210:201–215
  39. Waldstein SR, Rice SC, Thayer JF, Najjar SS, Scuteri A, Zonderman AB. Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging. Hypertension. 2008;51:99–104
  40. Wong DF, Wagner HN, Dannals RF, Links JM, Frost JJ, Ravert HT, et al Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain. Science. 1984;226:1393–1396

PII: S0197-4580(09)00023-2

doi: 10.1016/j.neurobiolaging.2008.11.011

Neurobiology of Aging
Volume 30, Issue 4 , Pages 515-520 , April 2009

Article Tools

* Image Usage & Resolution