Neurobiology of Aging
Volume 31, Issue 10 , Pages 1679-1689 , October 2010

Potential amyloid plaque-specific peptides for the diagnosis of Alzheimer's disease

  • Lionel Larbanoix

      Affiliations

    • Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut, 24 Avenue du Champ de Mars, B-7000 Mons, Belgium
  • ,
  • Carmen Burtea

      Affiliations

    • Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut, 24 Avenue du Champ de Mars, B-7000 Mons, Belgium
  • ,
  • Sophie Laurent

      Affiliations

    • Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut, 24 Avenue du Champ de Mars, B-7000 Mons, Belgium
  • ,
  • Fred Van Leuven

      Affiliations

    • Experimental Genetics Group, KULeuven, Herestraat 49, B-3000 Leuven, Belgium
  • ,
  • Gérard Toubeau

      Affiliations

    • Department of Histology, University of Mons-Hainaut, 6 Avenue du Champ de Mars, B-7000 Mons, Belgium
  • ,
  • Luce Vander Elst

      Affiliations

    • Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut, 24 Avenue du Champ de Mars, B-7000 Mons, Belgium
  • ,
  • Robert N. Muller

      Affiliations

    • Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut, 24 Avenue du Champ de Mars, B-7000 Mons, Belgium
    • Corresponding Author InformationCorresponding author. Tel.: +32 65 373520; fax: +32 65 373520.

Received 26 February 2008 ,Revised 23 June 2008 ,Accepted 30 September 2008.

References 

  1. Benveniste H, Einstein G, Kim KR, Hulette C, Johnson A. Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. Proc. Natl. Acad. Sci. U.S.A. 1999;96(24):14079–14084
  2. Borthakur A, Gur T, Wheaton AJ, Corbo M, Trojanowski JQ, Lee VM-Y, et al. In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. MRI. 2006;24:1011–1017
  3. Boutry S, Burtea C, Laurent S, Toubeau G, Vander Elst L, Muller RN. Magnetic resonance imaging of inflammation with a specific selectin-targeted contrast agent. Magn. Reson. Med. 2005;53(4):800–807
  4. Brass SD, Chen NK, Mulkern RV, Bakshi R. Magnetic resonance imaging of iron deposition in neurological disorders. Top. Magn. Reson. Imaging. 2006;17(1):31–40
  5. Bryant LH, Brechbiel MW, Wu CC, Bulte JWM, Herynek V, Frank JA. Synthesis and relaxometry of high-generation (G=5, 7, 9, and 10) PAMAM dendrimer-DOTA-gadolinium chelates. J. Magn. Reson. Imaging. 1999;9(2):348–352
  6. Burtea C, Laurent S, Murariu O, Rattat D, Toubeau G, Verbruggen A, et al. Molecular imaging of αvβ3 integrin expression in atherosclerotic plaques with a mimetic of RGD peptide grafted to Gd-DTPA. Cardiovasc. Res. 2008;78(1):148–157
  7. Clackson T, Lowman HB. Phage Display: Practical Approach. New York: Oxford University Press Inc.; 2004;
  8. Dhenain M, El Tannir El TN, Wu TD, Guegan M, Volk A, Quintana C, et al. Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice. Neurobiol. Aging. 2007;
  9. Haataja L, Gurlo T, Huang CJ, Bulter PC. Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr. Rev. 2008;29(3):303–316
  10. Hartmann T, Bieger SC, Bruhl B, Tienari PJ, Ida N, Allsop D, et al. Distinct sites of intracellular production for Alzheimer's disease A beta 40/42 amyloid peptides. Nat. Med. 1997;3(9):1016–1020
  11. Higuchi M, Iwata N, Matsuba Y, Sato K, Sasamoto K, Saido TC. F-19 and H-1 MRI detection of amyloid beta plaques in vivo. Nat. Neurosci. 2005;8(4):527–533
  12. Huang XD, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, et al. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry. 1999;38(24):7609–7616
  13. Iversen LL, Mortishiresmith RJ, Pollack SJ, Shearman MS. The toxicity in-vitro of beta-amyloid protein. Biochem. J. 1995;311:1–16
  14. Jack CR, Garwood M, Wengenack TM, Borowski B, Curran GL, Lin J, et al. In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent. Magn. Reson. Med. 2004;52(6):1263–1271
  15. Jagust W, Reed B, Mungas D, Ellis W, Decarli C. What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?. Neurology. 2007;69(9):871–877
  16. Kang CK, Jayasinha V, Martin PT. Identification of peptides that specifically bind A beta(1–40) amyloid in vitro and amyloid plaques in Alzheimer's disease brain using phage display. Neurobiol. Dis. 2003;14(1):146–156
  17. Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv. Drug Deliv. Rev. 2001;47(1):65–81
  18. Lee SP, Falangola MF, Nixon RA, Duff K, Helpern JA. Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magn. Reson. Med. 2004;52(3):538–544
  19. Nordberg A. Amyloid plaque imaging in vivo: current achievement and future prospects. Eur. J. Nucl. Med. Mol. Imaging. 2008;35(s1):s46–s50
  20. Orner BP, Liu L, Murphy RM, Kiessling LL. Phage display affords peptides that modulate beta-amyloid aggregation. J. Am. Chem. Soc. 2006;128(36):11882–11889
  21. Poduslo JF, Curran GL, Peterson JA, McCormick DJ, Fauq AH, Khan MA, et al. Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood–brain barrier permeability, and in vivo targeting to Alzheimer's disease amyloid plaques. Biochemistry. 2004;43(20):6064–6075
  22. Rapoport M, Ferreira A. PD98059 prevents neurite degeneration induced by fibrillary beta-amyloid in mature hippocampal neurons. J. Neurochem. 2000;74(1):125–133
  23. Rogers J, Lue LF. Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease. Neurochem. Int. 2001;39(5/6):333–340
  24. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press; 1989;
  25. Segers J, Laumonier C, Burtea C, Laurent S, Elst LV, Muller RN. From phage display to magnetophage, a new tool for magnetic resonance molecular imaging. Bioconjug. Chem. 2007;18(4):1251–1258
  26. Sigurdsson EM, Wadghiri YZ, Mosconi L, Blind JA, Knudsen E, Asuni A, et al. A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice. Neurobiol. Aging. 2007;
  27. Sipe JD. Amyloid Proteins. The Beta Sheet Conformation and Disease. New York: WILEY-VCH; 2005;
  28. Smith GP, Petrenko VA. Phage display. Chem. Rev. 1997;97(2):391–410
  29. Van Dorpe J, Smeijers L, Dewachter I, Nuyens D, Spittaels K, Van den Haute C, et al. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons. Am. J. Pathol. 2000;157(4):1283–1298
  30. Vanhoutte G, Dewachter I, Borghgraef P, Van Leuven F, Van der Linden A. Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease. Magn. Reson. Med. 2005;53(3):607–613
  31. Wadghiri YZ, Sigurdsson EM, Sadowski M, Elliott JI, Li YS, Scholtzova H, et al. Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magn. Reson. Med. 2003;50(2):293–302
  32. Weissleder R, Mahmood U. Molecular imaging. Radiology. 2001;219(2):316–333
  33. Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, et al. Selection of d-amino-acid peptides that bind to Alzheimer's disease amyloid peptide A beta(1–42) by mirror image phage display. Chembiochem. 2003;4(8):748–753
  34. Zhao M, Kircher MF, Josephson L, Weissleder R. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug. Chem. 2002;13(4):840–844
  35. Zwick MB, Shen JQ, Scott J. Phage-displayed peptide libraries. Curr. Opin. Biotechnol. 1998;9(4):427–436

PII: S0197-4580(08)00356-4

doi: 10.1016/j.neurobiolaging.2008.09.021

Neurobiology of Aging
Volume 31, Issue 10 , Pages 1679-1689 , October 2010