Neurobiology of Aging
Volume 31, Issue 10 , Pages 1669-1678 , October 2010

Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease

  • Meredith N. Braskie

      Affiliations

    • Helen Wills Neuroscience Institute, University of California Berkeley, CA 94720, USA
    • Ahmanson-Lovelace Brain Mapping Center, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Andrea D. Klunder

      Affiliations

    • Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Kiralee M. Hayashi

      Affiliations

    • Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Hillary Protas

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CA 90095, USA
    • Department of Biomathematics, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Vladimir Kepe

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Karen J. Miller

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • S.-C. Huang

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Jorge R. Barrio

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Linda M. Ercoli

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Prabha Siddarth

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Nagichettiar Satyamurthy

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Jie Liu

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Arthur W. Toga

      Affiliations

    • Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Susan Y. Bookheimer

      Affiliations

    • Ahmanson-Lovelace Brain Mapping Center, David Geffen School of Medicine at UCLA, CA 90095, USA
    • Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, CA 90095, USA
    • Department of Psychology, David Geffen School of Medicine at UCLA, CA 90095, USA
  • ,
  • Gary W. Small

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, CA 90095, USA
    • UCLA Center on Aging, CA 90095, USA
  • ,
  • Paul M. Thompson

      Affiliations

    • Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, CA 90095, USA
    • Corresponding Author InformationCorresponding author at: Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, 635 Charles E. Young Drive South, Suite 225E, Los Angeles, CA 90095-7332, USA. Tel.: +1 310 206 2101; fax: +1 310 206 5518.

Received 26 March 2008 ,Revised 9 July 2008 ,Accepted 22 September 2008.

References 

  1. Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, et al. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J. Neurosci. 2001;21:RC189
  2. Agdeppa ED, Kepe V, Shoghi-Jadid K, Satyamurthy N, Small GW, Petric A, et al. In vivo and in vitro labeling of plaques and tangles in the brain of an Alzheimer's disease patient: a case study. Ann. Meet. J. Nuclear Med. 2001;42(Suppl 1):65P
  3. American Psychological Association, 2000. Diagnosis and Statistical Manual of Mental Disorders DSM-IV-TR (Text Revision). Washington, DC.
  4. Apostolova LG, Lu PH, Rogers S, Dutton RA, Hayashi KM, Toga AW, et al. 3D mapping of mini-mental state examination performance in clinical and preclinical Alzheimer disease. Alzheimer Dis. Assoc. Disord. 2006;20:224–231
  5. Berg L, McKeel DW, Miller JP, Storandt M, Rubin EH, Morris JC, et al. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch. Neurol. 1998;55:326–335
  6. Binder LI, Guillozet-Bongaarts AL, Garcia-Sierra F, Berry RW. Tau, tangles, and Alzheimer's disease. Biochim. Biophys. Acta. 2005;1739:216–223
  7. Bouras C, Hof PR, Giannakopoulos P, Michel JP, Morrison JH. Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital. Cereb. Cortex. 1994;4:138–150
  8. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl). 1991;82:239–259
  9. Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol. Aging. 1997;18:351–357
  10. Buckner RL, Snyder AZ, Shannon BJ, LaRossa G, Sachs R, Fotenos AF, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J. Neurosci. 2005;25:7709–7717
  11. Bullmore ET, Suckling J, Overmeyer S, Rabe-Hesketh S, Taylor E, Brammer MJ. Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain. IEEE Trans. Med. Imag. 1999;18:32–42
  12. Castellani RJ, Lee HG, Perry G, Smith MA. Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau. Am. J. Alzheimers Dis. Other Demen. 2006;21:126–130
  13. Collins DL, Neelin P, Peters TM, Evans AC. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J. Comput. Assist. Tomogr. 1994;18:192–205
  14. Giannakopoulos P, Herrmann FR, Bussiere T, Bouras C, Kovari E, Perl DP, et al. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology. 2003;60:1495–1500
  15. Gomez-Isla T, Price JL, McKeel DW, Morris JC, Growdon JH, Hyman BT. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 1996;16:4491–4500
  16. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiat. 1960;23:56–62
  17. Hayashi K.M., Thompson, P.M., Mega, M.S., Zoumalan, C.I., 2002. Medial hemispheric surface gyral pattern delineation in 3D: surface curve protocol, http://www.loni.ucla.edu/∼khayashi/Public/Medial_surface/MedialLinesProtocol.
  18. Jones S, Laukka EJ, Backman L. Differential verbal fluency deficits in the preclinical stages of Alzheimer's disease and vascular dementia. Cortex. 2006;42:347–355
  19. Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann. Neurol. 2004;55:306–319
  20. Lerch JP, Pruessner JC, Zijdenbos A, Hampel H, Teipel SJ, Evans AC. Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy. Cereb. Cortex. 2005;15:995–1001
  21. Liu J, Kepe V, Zabjek A, Petric A, Padgett HC, Satyamurthy N, et al. High-yield, automated radiosynthesis of 2-(1-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile ([18F]FDDNP) ready for animal or human administration. Mol. Imag. Biol. 2007;9:6–16
  22. Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL. Distribution volume ratios without blood sampling from graphical analysis of PET data. J. Cereb. Blood Flow Metab. 1996;16:834–840
  23. MacDonald D, Kabani N, Avis D, Evans AC. Automated 3D extraction of inner and outer surfaces of cerebral cortex from MRI. Neuroimage. 2000;12:340–356
  24. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 1984;34:939–944
  25. Mintun MA, Larossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, et al. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology. 2006;67:446–452
  26. Petersen RC. Mild cognitive impairment as a diagnostic entity. J. Intern. Med. 2004;256:183–194
  27. Protas H, Thompson PM, Hayashi KM, Huang SC. Cortical brain surface mapping for studying partial volume effects in brain FDG-PET images. In: Proceedings of the 52nd Annual Meeting of the Society for Nuclear Medicine (SNM). Toronto, Canada, June 18–22, 2005. 2005;
  28. Sapiro G. Geometric Partial Differential Equations and Image Analysis. Cambridge University Press; 2001;
  29. Selkoe DJ. Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J. Alzheimer's Dis. 2001;3:75–80
  30. Shattuck DW, Sandor-Leahy SR, Schaper KA, Rottenberg DA, Leahy RM. Magnetic resonance image tissue classification using a partial volume model. Neuroimage. 2001;13:856–876
  31. Singh V, Chertkow H, Lerch JP, Evans AC, Dorr AE, Kabani NJ. Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer's disease. Brain. 2006;129:2885–2893
  32. Small GW, Ercoli LM, Silverman DH, Huang SC, Komo S, Bookheimer SY, et al. Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2000;97:6037–6042
  33. Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, et al. PET of brain amyloid and tau in mild cognitive impairment. N. Engl. J. Med. 2006;355:2652–2663
  34. Smith SM. Fast robust automated brain extraction. Hum. Brain Mapp. 2002;17:143–155
  35. Sowell E.R., Thompson, P.M., Mega, M.S., Zoumalan, C.I., Lindshield, C.J., Rex, D.E., 2000. Gyral pattern delineation in 3D: surface curve protocol, http://www.loni.ucla.edu/∼esowell/new_sulc_var.html.
  36. Sowell ER, Thompson PM, Leonard CM, Welcome SE, Kan E, Toga AW. Longitudinal mapping of cortical thickness and brain growth in normal children. J. Neurosci. 2004;24(38):8223–8231
  37. Tabert MH, Manly JJ, Liu X, Pelton GH, Rosenblum S, Jacobs M, et al. Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Arch. Gen. Psychiat. 2006;63:916–924
  38. Thal DR, Rub U, Orantes M, Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology. 2002;58:1791–1800
  39. Thompson PM, Hayashi KM, de Zubicaray G, Janke AL, Rose SE, Semple J, et al. Dynamics of gray matter loss in Alzheimer's disease. J. Neurosci. 2003;23:994–1005
  40. Thompson PM, Hayashi KM, Sowell ER, Gogtay N, Giedd JN, Rapoport JL, et al. Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia. Neuroimage. 2004;23(Suppl 1):S2–18
  41. Verhoeff NP, Wilson AA, Takeshita S, Trop L, Hussey D, Singh K, et al. In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET. Am. J. Geriatr. Psychiat. 2004;12:584–595
  42. Watson D, Castano E, Kokjohn TA, Kuo YM, Lyubchenko Y, Pinsky D, et al. Physicochemical characteristics of soluble oligomeric A beta and their pathologic role in Alzheimer's disease. Neurol. Res. 2005;27:869–881

PII: S0197-4580(08)00347-3

doi: 10.1016/j.neurobiolaging.2008.09.012

Neurobiology of Aging
Volume 31, Issue 10 , Pages 1669-1678 , October 2010