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Neurobiology of Aging
Volume 31, Issue 9
, Pages 1543-1553
, September 2010
Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner
References
- . Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 2005;25:722–729
- . Developmental changes in the association of NMDA receptors with lipid rafts. J. Neurosci. Res. 2007;85:1876–1883
- . Modification of age-induced changes in heme and hemoproteins by testosterone in male rats. Mech. Ageing Dev. 1983;23:285–296
- . Aberration of heme and hemoprotein in aged female rats. Mech. Ageing Dev. 1987;38:189–197
- . Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. J. Neurochem. 2005;92:1386–1398
- . Lovastatin inhibits the extracellular-signal-regulated kinase pathway in immortalized rat brain neuroblasts. Biochem. J. 2007;401:175–183
- . Heme deficiency is associated with senescence and causes suppression of N-methyl-D-aspartate receptor subunits expression in primary cortical neurons. Mol. Pharmacol. 2006;69:697–705
- . Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation. J. Neurosci. 2007;27:8475–8485
- . Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool. Am. J. Pathol. 2005;166:1041–1053
- . HIV-based vectors. Preparation and use. Methods Mol. Med. 2002;69:259–274
- . Rosuvastatin upregulates the antioxidant defense protein heme oxygenase-1. Biochem. Biophys. Res. Commun. 2004;325:871–876
- . The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells. Free Radic. Biol. Med. 2004;37:2064–2071
- . Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. J. Neurosci. 2003;23:3262–3271
- . Age-associated increases in heme oxygenase-1 and ferritin immunoreactivity in the autopsied brain. Leg Med. (Tokyo). 2003;5(Suppl 1):S360–S366
- . Simvastatin-Induced Heme Oxygenase-1 Increases Apoptosis of Neuro 2A Cells in Response to Glucose Deprivation. Toxicol. Sci. 2008;101:112–121
- . Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo. Biochem. Biophys. Res. Commun. 2006;343:738–744
- . Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. J. Pharmacol. Exp. Ther. 2005;312:786–793
- . Heme oxygenase in experimental intracerebral hemorrhage: the benefit of tin-mesoporphyrin. J. Neuropathol. Exp. Neurol. 2004;63:587–597
- . Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc. Natl. Acad. Sci. U.S.A. 2006;103:3869–3874
- . Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. J. Neurosci. Res. 2002;68:627–635
- . Pleiotropic effects of statins. Annu. Rev. Pharmacol. Toxicol. 2005;45:89–118
- . CNS synaptogenesis promoted by glia-derived cholesterol. Science. 2001;294:1354–1357
- . Processing of neuropeptide Y, galanin, and somatostatin in the cerebrospinal fluid of patients with Alzheimer’s disease and frontotemporal dementia. Peptides. 2001;22:2105–2112
- . Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampus. Neurosci. Lett. 2003;340:9–12
- . An in vitro study of the effects of lovastatin on human fetal brain cells. Neurotoxicol. Teratol. 1995;17:31–39
- . Astrocytes aged in vitro show a decreased neuroprotective capacity. J. Neurochem. 2007;101:794–805
- . GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures. Free Radic. Biol. Med. 2005;39:1611–1619
- . Alpha-spectrins are major ubiquitinated proteins in rat hippocampal neurons and components of ubiquitinated inclusions in neurodegenerative disorders. Brain Res. Bull. 2001;54:405–411
- . Why heme needs to be degraded to iron, biliverdin IXalpha, and carbon monoxide?. Antioxid. Redox Signal. 2004;6:819–824
- . The role of heme in gene expression. Int. J. Hematol. 1996;63:167–178
- . Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress. Ann. N. Y. Acad. Sci. 2004;1012:84–93
- . Heme oxygenase expression in human central nervous system disorders. Free Radic. Biol. Med. 2004;37:1995–2011
- . Over-expression of heme oxygenase-1 promotes oxidative mitochondrial damage in rat astroglia. J. Cell. Physiol. 2006;206:655–663
- . Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development. J. Neurosci. 2007;27:6417–6427
- . CYP2E1 overexpression up-regulates both non-specific delta-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE/2E1. Int. J. Mol. Med. 2003;11:57–62
- . Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors. Hepatology. 1998;27:808–814
- . Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. Neurosci. Lett. 2004;354:107–110
- . Inhibition of delta-aminolevulinic acid dehydrase by 4,6-dioxoheptanoic acid. J. Biol. Chem. 1981;256:9915–9923
- . Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier. J. Pharmacol. Exp. Ther. 1993;267:1085–1090
- . Erythropoietic protoporphyria in the house mouse. A recessive inherited ferrochelatase deficiency with anemia, photosensitivity, and liver disease. J. Clin. Invest. 1991;88:1730–1736
- . Prevention of stroke and dementia with statins: Effects beyond lipid lowering. Am. J. Cardiol. 2003;91:23B–29B
- . Statin-associated memory loss: analysis of 60 case reports and review of the literature. Pharmacotherapy. 2003;23:871–880
- . Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage. Brain. 2007;130:1643–1652
- . The lipid and non-lipid effects of statins. Pharmacol. Ther. 2003;99:95–112
- . Heme oxygenase (HO-1): His-132 stabilizes a distal water ligand and assists catalysis. Biochemistry. 1996;35:930–936
- . Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science. 2007;318:1786–1789
- . 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J. Neurosci. 2003;23:11104–11111
PII: S0197-4580(08)00329-1
doi: 10.1016/j.neurobiolaging.2008.09.004
© 2008 Elsevier Inc. All rights reserved.
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Neurobiology of Aging
Volume 31, Issue 9
, Pages 1543-1553
, September 2010
