Neurobiology of Aging
Volume 31, Issue 5 , Pages 772-779 , May 2010

Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease

  • IL Han Choo

      Affiliations

    • Department of Neuropsychiatry and Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    • ,
  • Dong Young Lee

      Affiliations

    • Department of Neuropsychiatry and Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    • Interdisciplinary Program for Cognitive Science, Seoul National University, Seoul, Republic of Korea
    • Corresponding Author InformationCorresponding author at: Department of Neuropsychiatry, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea. Tel.: +82 2 2072 2205; fax: +82 2 744 7241.
    • ,
  • Jungsu S. Oh

      Affiliations

    • Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    • ,
  • Jae Sung Lee

      Affiliations

    • Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    • ,
  • Dong Soo Lee

      Affiliations

    • Interdisciplinary Program for Cognitive Science, Seoul National University, Seoul, Republic of Korea
    • Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    • ,
  • In Chan Song

      Affiliations

    • Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea
    • ,
  • Jong Choul Youn

      Affiliations

    • Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Kyunggi, Republic of Korea
    • ,
  • Shin Gyeom Kim

      Affiliations

    • Department of Neuropsychiatry and Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    • ,
  • Ki Woong Kim

      Affiliations

    • Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Kyunggi, Republic of Korea
    • ,
  • Jin Hyeong Jhoo

      Affiliations

    • Department of Psychiatry, Kangwon National University Hospital, Chuncheon, Kangwon, Republic of Korea
    • ,
  • Jong Inn Woo

      Affiliations

    • Department of Neuropsychiatry and Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    • Interdisciplinary Program for Cognitive Science, Seoul National University, Seoul, Republic of Korea
    • Neuroscience Research Institute of the Medical Research Center, Seoul National University, Seoul, Republic of Korea

Received 31 January 2008 ,Revised 4 June 2008 ,Accepted 29 June 2008.

References 

  1. Amaral DG, Insausti R, Cowan WM. The commissural connections of the monkey hippocampal formation. J. Comp. Neurol. 1984;224(3):307–336
  2. American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC.
  3. Baron JC, Chételat G, Desgranges B, Perchey G, Landeau B, de la Sayette V, et al. In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease. Neuroimage. 2001;14(2):298–309
  4. Bottino CM, Castro CC, Gomes RL, Buchpiguel CA, Marchetti RL, Neto MR. Volumetric MRI measurements can differentiate Alzheimer's disease, mild cognitive impairment, and normal aging. Int. Psychogeriatr. 2002;14(1):59–72
  5. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta. Neuropathol. 1991;82(4):239–259
  6. Braak H, Braak E, Bohl J. Staging of Alzheimer-related cortical destruction. Eur. Neurol. 1993;33(6):403–408
  7. Brun A, Englund E. A white matter disorder in dementia of the Alzheimer's type: a pathoanatomical study. Ann. Neurol. 1986;19(3):253–262
  8. Buckner RL, Head D, Parker J, Fotenos AF, Marcus D, Morris JC, et al. A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume. Neuroimage. 2004;23(2):724–738
  9. Callen DJ, Black SE, Gao F, Caldwell CB, Szalai JP. Beyond the hippocampus: MRI volumetry confirms widespread limbic atrophy in AD. Neurology. 2001;57(9):1669–1674
  10. Catani M, Howard RJ, Pajevic S, Jones DK. Virtual in vivo interactive dissection of white matter fasciculi in the human brain. NeuroImage. 2002;17(1):77–94
  11. Chételat G, Desgranges B, de la Sayette V, Viader F, Eustache F, Baron JC. Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease?. Neurology. 2003;60(8):1374–1377
  12. Convit A, De Leon MJ, Tarshish C, De Santi S, Tsui W, Rusinek H, et al. Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease. Neurobiol. Aging. 1997;18(2):131–138
  13. Du AT, Schuff N, Amend D, Laakso MP, Hsu YY, Jagust WJ, et al. Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry. 2001;71(4):441–447
  14. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1,5T in Alzheimer's dementia and normal aging. Am. J. Radiol. 1987;149(2):351–356
  15. Fellgiebel A, Müller MJ, Wille P, Dellani PR, Scheurich A, Schmidt LG, et al. Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment. Neurobiol. Aging. 2005;26(8):1193–1198
  16. Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, et al. Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's disease. NeuroImage. 2007;36(1):1–7
  17. Frisoni GB, Testa C, Zorzan A, Sabattoli F, Beltramello A, Soininen H, et al. Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry. J. Neurol. Neurosurg. Psychiatry. 2002;73(6):657–664
  18. Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, et al. MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. Am. J. Neuroradiol. 1998;19(4):659–671
  19. Ishii K, Mori T, Hirono N, Mori E. Glucose metabolic dysfunction in subjects with a clinical dementia rating of 0.5. J. Neurol. Sci. 2003;215(1–2):71–74
  20. Jack CR, Petersen RC, Xu YC, O’Brien PC, Smith GE, Ivnik RJ, et al. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology. 1999;52(7):1397–1403
  21. Jones BF, Barnes J, Uylings HBM, Fox NC, Frost C, Witter MP, et al. Differential regional atrophy of the cingulated gyrus in Alzheimer disease: a volumetric MRI study. Cereb. Cortex. 2006;16(12):1701–1708
  22. Kalus P, Slotboom J, Gallinat J, Mahlberg R, Cattapan-Ludewig K, Wiest R, et al. Examining the gateway to the limbic system with diffusion tensor imaging: the perforant pathway in dementia. NeuroImage. 2006;30(3):713–720
  23. Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, et al. MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology. 2002;58(8):1188–1196
  24. Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, et al. Diffusion tensor imaging: concepts and applications. J. Magn. Reson. Imaging. 2001;13(4):534–546
  25. Lee DY, Lee KU, Lee JH, Kim KW, Jhoo JH, Kim SY, et al. A normative study of the CERAD neuropsychological assessment battery in the Korean elderly. J. Int. Neuropsychol. Soc. 2004;10(1):72–81
  26. Lee JH, Lee KU, Lee DY, Kim KW, Jhoo JH, Kim JH, et al. Development of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment battery. J. Gerontol. Psychol. Sci. 2002;57(1):47–53
  27. Mckhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task force on Alzheimer's disease. Neurology. 1984;34(7):939–944
  28. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann. Neurol. 1997;42(1):85–94
  29. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43(11):2412–2414
  30. Mosconi L, Tsui WH, De Santi S, Li J, Rusinek H, Convit A, et al. Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis. Neurology. 2005;64(11):1860–1867
  31. Mufson EJ, Pandya DN. Some observations on the course and composition of the cingulum bundle in the rhesus monkey. J. Comp. Neurol. 1984;225(1):31–43
  32. Müller MJ, Greverus D, Dellani PR, Weibrich C, Wille PR, Scheurich A, et al. Functional implications of hippocampal volume and diffusivity in mild cognitive impairment. NeuroImage. 2005;28(4):1033–1042
  33. Nestor PJ, Fryer TD, Hodges JR. Declarative memory impairments in Alzheimer's disease and semantic dementia. NeuroImage. 2006;30(3):1010–1020
  34. Nestor PJ, Fryer TD, Ikeda M, Hodges JR. Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease). Eur. J. Neurosci. 2003;18(9):2663–2667
  35. Nestor PJ, Fryer TD, Smielewski P, Hodges JR. Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment. Ann. Neurol. 2003;54(3):343–351
  36. Oh JS, Song IC, Lee JS, Kang H, Park KS, Kang E, et al. Tractography-guided statistics (TGIS) in diffusion tensor imaging for the detection of gender difference of fiber integrity in the midsagittal and parasagittal corpora callosa. NeuroImage. 2007;36(3):606–616
  37. Pajevic S, Pierpaoli C. Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain. Magn. Reson. Med. 1999;42(3):526–540
  38. Pantel J, O’Leary DS, Cretsinger K, Bockholt HJ, Keefe H, Magnotta VA, et al. A new method for the in vivo volumetric measurement of the human hippocampus with high neuroanatomical accuracy. Hippocampus. 2000;10(6):752–758
  39. Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hänninen T, Laakso MP, et al. Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol. Aging. 2004;25(3):303–310
  40. Petersen RC. Mild cognitive impairment as a diagnostic entity. J. Int. Med. 2004;256(3):183–194
  41. Rose SE, McMahon KL, Janke AL, O’Dowd B, de Zubicaray G, Strudwick MW, et al. Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment. J. Neurol. Neurosurg. Psychiatry. 2006;77(10):1122–2112
  42. Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, et al. PET of brain amyloid and tau in mild cognitive impairment. N. Engl. J. Med. 2006;355(25):2652–2653
  43. Takahashi S, Yonezawa H, Takahashi J, Kudo M, Inoue T, Tohgi H. Selective reduction of diffusion anisotropy in white matter of Alzheimer's disease brains measured by 3.0 Tesla magnetic resonance imaging. Neurosci. Lett. 2002;332(1):45–48
  44. Vogt BA, Van Hosesen GW, Vogt LJ. Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease. Acta. Neuropathol. 1990;80(6):581–589
  45. Vogt BA, Vogt LJ, Vrana KE, Gioia L, Meadows RS, Challa VR, et al. Multivariate analysis of laminar patterns of neurodegeneration in posterior cingulate cortex in Alzheimer's disease. Exp. Neurol. 1998;153(1):8–22
  46. Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PCM, Mori S. Fiber tract-based atlas of human white matter anatomy. Radiology. 2004;230(1):77–87
  47. Xie S, Xiao JX, Wang YH, Wu HK, Gong GL, Jiang XX. Evaluation of bilateral cingulum with tractography in patients with Alzheimer's disease. Neuroreport. 2005;16(12):1275–1278
  48. Xu Y, Jack CR, O’Brien PC, Kokmen E, Smith GE, Ivnik RJ, et al. Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD. Neurology. 2000;54(9):1760–1767
  49. Zhang Y, Schuff N, Jahng GH, Bayne W, Mori S, Schad L, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology. 2007;68(1):13–19

PII: S0197-4580(08)00230-3

doi: 10.1016/j.neurobiolaging.2008.06.015

Neurobiology of Aging
Volume 31, Issue 5 , Pages 772-779 , May 2010

Article Tools

* Image Usage & Resolution