Neurobiology of Aging
Volume 31, Issue 5 , Pages 725-731 , May 2010

Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP

  • Rita Joao Guerreiro

      Affiliations

    • Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    • Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal
    • ,
  • Miquel Baquero

      Affiliations

    • Neurology Department, Hospital Universitario “La Fe”, Valencia, Spain
    • ,
  • Rafael Blesa

      Affiliations

    • Memory Unit, Alzheimer's Laboratory, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    • Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, UK
    • ,
  • Mercè Boada

      Affiliations

    • Alzheimer Research Center, Memory Clinic. Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain
    • ,
  • Jose Miguel Brás

      Affiliations

    • Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    • Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal
    • ,
  • Maria J. Bullido

      Affiliations

    • Centro de Biología Molecular Severo Ochoa, Madrid, Spain
    • Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, UK
    • ,
  • Ana Calado

      Affiliations

    • Hospital Santo António dos Capuchos, Lisboa, Portugal
    • ,
  • Richard Crook

      Affiliations

    • Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    • ,
  • Carla Ferreira

      Affiliations

    • Hospital de Sao Marcos, Braga, Portugal
    • ,
  • Ana Frank

      Affiliations

    • Servicio de Neurología, Hospital Universitario La Paz, Madrid, Spain
    • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
    • ,
  • Teresa Gómez-Isla

      Affiliations

    • Memory Unit, Alzheimer's Laboratory, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
    • ,
  • Isabel Hernández

      Affiliations

    • Alzheimer Research Center, Memory Clinic. Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain
    • ,
  • Alberto Lleó

      Affiliations

    • Memory Unit, Alzheimer's Laboratory, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
    • ,
  • Alvaro Machado

      Affiliations

    • Hospital de Sao Marcos, Braga, Portugal
    • ,
  • Pablo Martínez-Lage

      Affiliations

    • Alzheimer Research Center, Memory Clinic. Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain
    • ,
  • José Masdeu

      Affiliations

    • Neurogenetics Laboratory, Division of Neurociences. Center for Applied Medical Research (CIMA), University of Navarra Medical School, Pamplona, Spain
    • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
    • ,
  • Laura Molina-Porcel

      Affiliations

    • Memory Unit, Alzheimer's Laboratory, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
    • ,
  • José L. Molinuevo

      Affiliations

    • Alzheimer's Disease and Other Cognitive Disorders Unit, Department of Neurology, Institute of Neurosciences, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain
    • ,
  • Pau Pastor

      Affiliations

    • Neurogenetics Laboratory, Division of Neurociences. Center for Applied Medical Research (CIMA), University of Navarra Medical School, Pamplona, Spain
    • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
    • ,
  • Jordi Pérez-Tur

      Affiliations

    • Institut de Biomedicina de Valencia-CSIC, Valencia, Spain
    • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
    • ,
  • Rute Relvas

      Affiliations

    • Hospital Santo António dos Capuchos, Lisboa, Portugal
    • ,
  • Catarina Resende Oliveira

      Affiliations

    • Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal
    • Neurology Service, Coimbra University Hospital, Coimbra, Portugal
    • ,
  • Maria Helena Ribeiro

      Affiliations

    • Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal
    • ,
  • Ekaterina Rogaeva

      Affiliations

    • Division of Neurology, Department of Medicine, University Health Network, Toronto, Ont., Canada
    • ,
  • Alfredo Sa

      Affiliations

    • Hospital de Leiria, Leiria, Portugal
    • ,
  • Lluís Samaranch

      Affiliations

    • Neurogenetics Laboratory, Division of Neurociences. Center for Applied Medical Research (CIMA), University of Navarra Medical School, Pamplona, Spain
    • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
    • ,
  • Raquel Sánchez-Valle

      Affiliations

    • Alzheimer's Disease and Other Cognitive Disorders Unit, Department of Neurology, Institute of Neurosciences, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain
    • ,
  • Isabel Santana

      Affiliations

    • Neurology Service, Coimbra University Hospital, Coimbra, Portugal
    • ,
  • Lluís Tàrraga

      Affiliations

    • Alzheimer Research Center, Memory Clinic. Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain
    • ,
  • Fernando Valdivieso

      Affiliations

    • Centro de Biología Molecular Severo Ochoa, Madrid, Spain
    • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
    • ,
  • Andrew Singleton

      Affiliations

    • Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    • ,
  • John Hardy

      Affiliations

    • Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    • Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, UK
    • ,
  • Jordi Clarimón

      Affiliations

    • Memory Unit, Alzheimer's Laboratory, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
    • Corresponding Author InformationCorresponding author at: Memory Unit, Alzheimer's Laboratory, Neurology Department, Hospital de la Santa Creu i Sant Pau, Sant Antoni Ma Claret 167, Barcelona 08025, Spain. Tel.: +34 93 291 90 50x2185; fax: +34 93 291 91 78.

Received 4 May 2008 ,Revised 9 June 2008 ,Accepted 20 June 2008.

References 

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PII: S0197-4580(08)00219-4

doi: 10.1016/j.neurobiolaging.2008.06.012

Neurobiology of Aging
Volume 31, Issue 5 , Pages 725-731 , May 2010

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