Neurobiology of Aging
Volume 30, Issue 6 , Pages 847-863 , June 2009

Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin

  • David F. Fischer

      Affiliations

    • Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    • Corresponding Author InformationCorresponding author. Present address: BioFocus DPI, a Galapagos Company, PO Box 127, 2300 CA Leiden, The Netherlands. Tel.: +31 71 7506 728; fax: +31 71 7506 701.
    • These authors contributed equally.
  • ,
  • Renske van Dijk

      Affiliations

    • Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    • These authors contributed equally.
  • ,
  • Paula van Tijn

      Affiliations

    • Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    • These authors contributed equally.
    • Present address: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences & University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
  • ,
  • Barbara Hobo

      Affiliations

    • Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
  • ,
  • Marian C. Verhage

      Affiliations

    • Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
  • ,
  • Roel C. van der Schors

      Affiliations

    • Department of Molecular and Cellular Neurobiology, Research Institute Neurosciences, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
  • ,
  • Ka Wan Li

      Affiliations

    • Department of Molecular and Cellular Neurobiology, Research Institute Neurosciences, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
  • ,
  • Jan van Minnen

      Affiliations

    • Department of Molecular and Cellular Neurobiology, Research Institute Neurosciences, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
  • ,
  • Elly M. Hol

      Affiliations

    • Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
  • ,
  • Fred W. van Leeuwen

      Affiliations

    • Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    • Maastricht University, Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author at: Maastricht University, Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands. Tel.: +31 43 3881044; fax: +31 43 367 1096.

Received 6 March 2008 ,Revised 28 May 2008 ,Accepted 18 June 2008.

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PII: S0197-4580(08)00216-9

doi: 10.1016/j.neurobiolaging.2008.06.009

Neurobiology of Aging
Volume 30, Issue 6 , Pages 847-863 , June 2009