Neurobiology of Aging
Volume 31, Issue 5 , Pages 780-786 , May 2010

Altered connectivity among emotion-related brain regions during short-term memory in Alzheimer's disease

  • R. Shayna Rosenbaum

      Affiliations

    • Department of Psychology, York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3
    • The Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, Ontario, Canada M5A 2E1
    • Corresponding Author InformationCorresponding author at: Department of Psychology, York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3. Tel.: +1 416 736 2100x20449; fax: +1 416 736 5662.
  • ,
  • Maura L. Furey

      Affiliations

    • Neuroimaging Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, USA
  • ,
  • Barry Horwitz

      Affiliations

    • Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
  • ,
  • Cheryl L. Grady

      Affiliations

    • The Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, Ontario, Canada M5A 2E1
    • Departments of Psychology and Psychiatry, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada M5S 3G3

Received 5 October 2007 ,Revised 30 May 2008 ,Accepted 9 June 2008.

References 

  1. Amaral DG, Price JL, Pitkanen A, Carmichael ST. Anatomical organization of the primate amygdaloid complex. In:  Aggleton JP editors. The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction. New York: Wiley Liss; 1992;p. 1–66
  2. Azari NP, Rapoport SI, Grady CL, Schapiro MB, Salerno JA, Gonzales-Aviles A, et al. Patterns of interregional correlations of cerebral glucose metabolic rates in patients with dementia of the Alzheimer type. Neurodegeneration. 1992;1:101–111
  3. Bechara A, Tranel D, Damasio H, Adolphs R, Rockland C, Damasio AR. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science. 1995;269:1115–1118
  4. Bokde AL, Lopez-Bayo P, Meindl T, Pechler S, Born C, Faltraco F, et al. Functional connectivity of the fusiform gyrus during a face-matching task in subjects with mild cognitive impairment. Brain. 2006;129:1113–1124
  5. Braak H, Braak E, Bohl J. Staging of Alzheimer-related cortical destruction. Eur. Neurol. 1993;33:403–408
  6. Cabeza R, Grady CL, Nyberg L, McIntosh AR, Tulving E, Kapur S, et al. Age-related differences in neural activity during memory encoding and retrieval: a positron emission tomography study. J. Neurosci. 1997;17:391–400
  7. Chase TN, Burrows GH, Mohr E. Cortical glucose utilization patterns in primary degenerative dementias of the anterior and posterior types. Arch. Gerontol. Geriatr. 1987;6:289–297
  8. Critchley H, Daly E, Phillips M, Brammer M, Bullmore E, Williams S, et al. Explicit and implicit neural mechanisms for processing of social information from facial expressions: a functional magnetic resonance imaging study. Hum. Brain Mapp. 2000;9:93–105
  9. Dalgleish T. The emotional brain. Nat. Rev. Neurosci. 2004;5:582–589
  10. Dolan RJ, Fletcher P, Morris J, Kapur N, Deakin JF, Frith CD. Neural activation during covert processing of positive emotional facial expressions. Neuroimage. 1996;4:194–200
  11. Dolcos F, Kragel P, Wang L, McCarthy G. Role of the inferior frontal cortex in coping with distracting emotions. NeuroReport. 2006;17:1591–1594
  12. Dolcos F, McCarthy G. Brain systems mediating cognitive interference by emotional distraction. J. Neurosci. 2006;26:2072–2079
  13. Fitzgerald DA, Angstadt M, Jelsone LM, Nathan PJ, Phan KL. Beyond threat: amygdala reactivity across multiple expressions of facial affect. NeuroImage. 2006;30:1441–1448
  14. Gorno-Tempini ML, Pradelli S, Serafini M, Pagnoni G, Baraldi P, Porro C, et al. Explicit and incidental facial expression processing: an fMRI study. NeuroImage. 2001;14:465–473
  15. Grady CL, Haxby JV, Schapiro MB, Gonzalez-Aviles A, Kumar A, Ball MJ, et al. Subgroups in dementia of the Alzheimer type identified using positron emission tomography. J. Neuropsychiatry Clin. Neurosci. 1990;2:373–384
  16. Grady CL, Furey ML, Pietrini P, Horwitz B, Rapoport SI. Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. Brain. 2001;124:739–756
  17. Grady CL, Maisog JM, Horwitz B, Ungerleider LG, Mentis MJ, Salerno JA, et al. Age-related changes in cortical blood flow activation during visual processing of faces and location. J. Neurosci. 1994;14:1450–1462
  18. Grady CL, McIntosh AR, Beig S, Keightley ML, Burian H, Black SE. Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease. J. Neurosci. 2003;23:986–993
  19. Hamann S. Cognitive and neural mechanisms of emotional memory. Trends Cogn. Sci. 2001;5:394–400
  20. Haxby JV, Ungerleider LG, Horwitz B, Rapoport SI, Grady CL. Hemispheric differences in neural systems for face working memory: a PET-rCBF study. Hum. Brain Mapp. 1995;3:68–82
  21. Hornak J, Rolls ET, Wade D. Face and voice expression identification in patients with emotional and behavioural changes following ventral frontal lobe damage. Neuropsychologia. 1996;34:247–261
  22. Horwitz B, Grady CL, Schageter NL, Duara R, Rapoport SI. Intercorrelations of regional glucose metabolic rates in Alzheimer's disease. Brain Res. 1987;407:294–306
  23. Horwitz B, McIntosh AR, Haxby JV, Furey M, Salerno J, Schapiro MB, et al. Network analysis of PET-mapped visual pathways in Alzheimer's type dementia. NeuroReport. 1995;6:2287–2292
  24. Joreskog KG, Sorbom D. LISREL 8.3: User's Reference Guide. Mooresville: Scientific Software Inc.; 1999;
  25. Kazui H, Mori E, Hashimoto M, Hirono N, Imamura T, Tanimukai S, et al. Impact of emotion on memory. Controlled study of the influence of emotionally charged material on declarative memory in Alzheimer's disease. Br. J. Psychiatry. 2000;177:343–347
  26. Killgore WD, Yurgelun-Todd DA. Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy faces. NeuroImage. 2004;21:1215–1223
  27. Kilpatrick L, Cahill L. Amygdala modulation of parahippocampal and frontal regions during emotionally influenced memory storage. NeuroImage. 2003;20:2091–2099
  28. LaBar KS, Cabeza R. Cognitive neuroscience of emotional memory. Nat. Rev. Neurosci. 2006;7:54–64
  29. LaBar KS, Mesulam M, Gitelman DR, Weintraub S. Emotional curiosity: modulation of visuospatial attention by arousal is preserved in aging and early-stage Alzheimer's disease. Neuropsychologia. 2000;38:1734–1740
  30. McIntosh AR, Gonzalez-Lima F. Structural equation modeling and its application to network analysis in functional brain imaging. Hum. Brain Mapp. 1994;2:2–22
  31. Morris JS, Friston KJ, Buchel C, Frith CD, Young AW, Calder AJ, et al. A neuromodulatory role for the human amygdala in processing emotional facial expressions. Brain. 1998;121:147–157
  32. Nyberg L, McIntosh AR, Cabeza R, Nilsson L-G, Houle S, Habib R, et al. Network analysis of positron emission tomography regional cerebral blood flow data: ensemble inhibition during episodic memory retrieval. J. Neurosci. 1996;16:3753–3759
  33. Padovan C, Versace R, Thomas-Anterion C, Laurent B. Evidence for a selective deficit in automatic activation of positive information in patients with Alzheimer's disease in an affective priming paradigm. Neuropsychologia. 2002;40:335–339
  34. Perry RJ, Hodges JR. Spectrum of memory dysfunction in degenerative disease. Curr. Opin. Neurol. 1996;9:281–285
  35. Petrides M, Pandya DN. Comparative architectonic analysis of the human and macaque frontal cortex. In:  Boller F,  Grafman J editor. Handbook of Neuropsychology, vol. 9. Amsterdam: Elsevier; 1994;p. 17–57
  36. Phelps EA. Human emotion and memory: interactions of the amygdala and hippocampal complex. Curr. Opin. Neurobiol. 2004;14:198–202
  37. Phillips ML, Young AW, Senior C, Brammer M, Andrew C, Calder AJ, et al. A specific neural substrate for perceiving facial expressions of disgust. Nature. 1997;389:495–498
  38. Price CJ, Friston KJ. Functional imaging studies of neuropsychological patients: applications and limitations. Neurocase. 2002;8:345–354
  39. Ressler KJ, Mayberg HS. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat. Neurosci. 2007;10:1116–1124
  40. Stern Y, Moeller JR, Anderson KE, Luber B, Zubin NR, DiMauro AA, et al. Different brain networks mediate task performance in normal aging and AD: defining compensation. Neurology. 2000;55:1291–1297
  41. Stuss DT, Levine B. Adult clinical neuropsychology: lessons from studies of the frontal lobes. Annu. Rev. Psychol. 2002;53:401–433
  42. Suzuki WA, Amaral DG. Perirhinal and parahippocampal cortices of the macaque monkey: cortical afferents. J. Comp. Neurol. 1994;350:497–533
  43. Van Hoesen GW, Morecraft RJ, Vogt BA. Connections of the monkey cingulate cortex. In:  Vogt BA,  Gabriel M editor. Neurobiology of Cingulate Cortex and Limbic Thalamus: A Comprehensive Handbook. Boston: Birkhauser; 1993;p. 461–477
  44. Wang K, Liang M, Wang L, Tian L, Zhang X, Li K, et al. Altered functional connectivity in early Alzheimer's disease: a resting-state fMRI study. Hum. Brain Mapp. 2007;28:967–978
  45. Whalen PJ, Rauch SL, Etcoff NL, McInerney SC, Lee MB, Jenike MA. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J. Neurosci. 1998;18:411–418
  46. Williams MA, Morris AP, McGlone F, Abbott DF, Mattingley JB. Amygdala responses to fearful and happy facial expressions under conditions of binocular suppression. J. Neurosci. 2004;24:2898–2904
  47. Winograd E, Goldstein FC, Monarch ES, Peluso JP, Goldman WP. The mere exposure effect in patients with Alzheimer's disease. Neuropsychology. 1999;13:41–46

 This work was supported by a grant from the Canadian Institutes of Health Research (MOP 14036).

PII: S0197-4580(08)00208-X

doi: 10.1016/j.neurobiolaging.2008.06.002

Neurobiology of Aging
Volume 31, Issue 5 , Pages 780-786 , May 2010