Neurobiology of Aging
Volume 31, Issue 5 , Pages 765-771 , May 2010

Shorter telomeres may indicate dementia status in older individuals with Down syndrome

  • Edmund C. Jenkins

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 718 494 5236; fax: +1 718 494 1026.
    • ,
  • Lingling Ye

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    • ,
  • Hong Gu

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    • ,
  • Samantha A. Ni

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    • ,
  • Milen Velinov

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    • ,
  • Deborah Pang

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 West 168th St., New York, NY 10032, United States
    • ,
  • Sharon J. Krinsky-McHale

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    • ,
  • Warren B. Zigman

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    • ,
  • Nicole Schupf

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 West 168th St., New York, NY 10032, United States
    • ,
  • Wayne P. Silverman

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    • The Kennedy Krieger Institute and The Johns Hopkins University School of Medicine, Suite 222s, 707 North Broadway, Baltimore, MD 21205, United States

Received 12 February 2008 ,Revised 13 May 2008 ,Accepted 7 June 2008.

References 

  1. Ahmed A, Tollefsbol T. Telomeres and telomerase: basic science implications for aging. J. Am. Geriatr. Soc. 2001;49:1105–1109
  2. Allsopp RC, Caziri H, Patterson C, Boldsten S, Younglai EV, Futcher AB, et al. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 1992;89:10114–10118
  3. Aylward E, Burt D, Thorpe L, Lai F, Dalton A. Diagnosis of dementia in individuals with intellectual disability. J. Intellect. Disabil. Res. 1997;41:162–164
  4. Benetos A, Gardner JP, Zureik M, Labat C, Xiaobin L, Adamopoulos C, et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension. 2004;43(20):182–185
  5. Burt DB, Aylward E. Test battery for the diagnosis of dementia in individuals with intellectual disability. J. Intellect. Disabil. Res. 2000;44:262–270
  6. Damjanovic AK, Yang Y, Glaser R, Kiecolt-Glaser JK, Nguyen H, Laskowski B, et al. Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients. J. Immunol. 2007;179:4249–4254
  7. Devenny DA, Krinsky-McHale SJ, Sersen G, Silverman WP. Sequence of cognitive decline in dementia in adults with Down's syndrome. J. Intellect. Disabil. Res. 2000;44(Pt. 6):654–665
  8. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, et al. Accelerated telomere shortening in response to life stress. P.N.A.S. 2004;101(49):17312–17315
  9. Flanary BE, Streit WJ. Telomeres shorten with age in rat cerebellum and cortex in vivo. J. Anti-Aging Med. 2003;6:299–308
  10. Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, et al. Mild cognitive impairment. Lancet. 2006;367(9518):1262–1270
  11. Hao LY, Strong MA, Greider CW. Phosphorylation of H2AX at short telomeres in T cells and fibroblasts. J. Biol. Chem. 2004;279(43):45148–45154
  12. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC. Telomere reduction in human colorectal carcinomal and with ageing. Nature. 1990;346(6287):866–868
  13. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J. Lipid Res. 1990;31(3):545–548
  14. Jenkins EC, Velinov MT, Ye L, Gu H, Li S, Jenkins EC, et al. Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia. Neurobiol. Aging. 2006;27:41–45
  15. Lansdorp PM, Verwoerd NP, van de Rijke FM, Dragowska V, Little M-T, Dirks RW, et al. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 1996;5:685–691
  16. Lindsey J, McGill NI, Linsey LA, Gren DK, Cooke HJ. In vivo loss of telomeric repeats with age in humans. Mutat. Res. 1991;256(1):45–48
  17. Londoño-Vallejo JA, DerSarkissian H, Cazes L, Thomas G. Differences in telomere length between homologous chromosomes in humans. Nucleic Acids Res. 2001;29:3164–3171
  18. Panossian LA, Porter VR, Valenzuela HF, Znhu X, Reback E, Masterman D, et al. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol. Aging. 2003;24:77–84
  19. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch. Neurol. 1999;56(3):303–308
  20. Plentz RR, Caselitz M, Bleck JS, Gebel M, Flemming P, Kubicka S, et al. Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma. Hepatology. 2004;40(1):80–86
  21. Samani JJ, Boultby R, Butler R, Thompson JR, Goodall AH. Telomere shortening and atherosclerosis. Lancet. 2001;358(9280):472–473
  22. Schoeftner S, Blasco MA. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat. Cell Biol. 2008;10(2):228–236
  23. Schupf N, Kapell D, Lee JH, Zigman W, Canto B, Tycko B, et al. Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome. Ann. Neurol. 1996;40(5):799–801
  24. Schupf N, Pang D, Patel BN, Silverman W, Schubert R, Lai F, et al. Onset of dementia is associated with age at menopause in women with Down syndrome. Ann. Neurol. 2003;54:433–438
  25. Silverman W, Schupf N, Zigman W, Devenny D, Miezejeski C, Schubert R, et al. Dementia in adults with mental retardation: assessment at a single point in time. Am. J. Ment. Retard. 2004;109(2):111–125
  26. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, et al. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005;366(9486):662–664
  27. Valdes AM, Richards JB, Gardner JP, Swaminathan R, Kimura M, Xiaobin L, et al. Telomere length correlates with bone mineral density and is shorter in women with osteoporosis. Osteoporosis Int. 2007;18(9):1203–1210
  28. Vulliamy TJ, Dokal I. The diverse clinical presentation of mutations in the telomerase complex. Biochimie. 2007;90(1):122–130
  29. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, et al. Mild cognitive impairment—beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J. Intern. Med. 2004;256(3):240–246
  30. Zigman WB, Schupf N, Devenny DA, Miezejeski C, Ryan R, Urv TK, et al. Incidence and prevalence of dementia in elderly adults with mental retardation without Down syndrome. Am. J. Ment. Retard. 2004;109(2):126–141
  31. Zigman WB, Jenkins EC, Tycko B, Schupf N, Silverman W. Mortality is associated with Apolipoprotein E in nondemented adults with Down syndrome. Neurosci. Lett. 2005;390(2):93–97

PII: S0197-4580(08)00207-8

doi: 10.1016/j.neurobiolaging.2008.06.001

Neurobiology of Aging
Volume 31, Issue 5 , Pages 765-771 , May 2010

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