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Neurobiology of Aging
Volume 31, Issue 5
, Pages 813-825
, May 2010
Synaptic strength and postsynaptically silent synapses through advanced aging in rat hippocampal CA1 pyramidal neurons
References
- . Region-specific age effects on AMPA sensitivity: electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1. Hippocampus. 1992;2:457–468
- . Age-related decrease in the N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potential in hippocampal region CA1. Neurobiol. Aging. 1997;18:445–452
- . Do thin spines learn to be mushroom spines that remember?. Curr. Opin. Neurobiol. 2007;17:381–386
- . Warmer preparation of hippocampal slices prevents synapse proliferation that might obscure LTP-related structural plasticity. Neuropharmacology. 2007;52:55–59
- . AMPA receptor trafficking at excitatory synapses. Neuron. 2003;40:361–379
- . Neural plasticity in the ageing brain. Nat. Rev. Neurosci. 2006;7:30–40
- . Age-related spatial learning impairment is unrelated to spinophilin immunoreactive spine number and protein levels in hippocampus. Neurobiol. Aging. 2007;29:1256–1264
- . Learning, aging, and intrinsic neuronal plasticity. Trends Neurosci. 2006;29:587–599
- . Developmental increase in CA3-CA1 presynaptic function in the hippocampal slice. J. Neurophysiol. 1995;73:1821–1828
- . Long-term potentiation and functional synapse induction in developing hippocampus. Nature. 1996;381:71–75
- . Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell. 2007;6:319–325
- . Individual difference in neurocognitive aging of the medial temporal lobe. Age. 2006;28:221–223
- . Differences in the expression of AMPA and NMDA receptors between axospinous perforated and nonperforated synapses are related to the configuration and size of postsynaptic densities. J. Comp. Neurol. 2004;468:86–95
- . Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release. J. Neurosci. 2006;26:3482–3490
- . Silent synapses in developing hippocampus: lack of functional AMPA receptors or low probability of glutamate release?. Proc. Natl. Acad. Sci. U.S.A. 2000;97:9741–9746
- . Structural synaptic modifications associated with hippocampal LTP and behavioral learning. Cereb. Cortex. 2000;10:952–962
- . Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum. Neurobiol. Aging. 2004;25:407–416
- . Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function. Annu. Rev. Neurosci. 1994;17:341–371
- . Development of excitatory circuitry in the hippocampus. J. Neurophysiol. 1998;79:2013–2024
- . Evidence for silent synapses: implications for the expression of LTP. Neuron. 1995;15:427–434
- . Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells. Proc. Natl. Acad. Sci. U.S.A. 1996;93:8710–8715
- . Silent synapses during development of thalamocortical inputs. Neuron. 1997;18:269–280
- . Structure-stability-function relationships of dendritic spines. Trends Neurosci. 2003;26:360–368
- . Organelles and trafficking machinery for postsynaptic plasticity Annu. Rev. Neurosci. 2006;29:325–362
- . Hypothesis on the regulation of cytosol calcium concentration and the aging brain. Neurobiol. Aging. 1987;8:345–346
- . Dendritic spines disappear with chilling but proliferate excessively upon rewarming of mature hippocampus. Neuroscience. 2004;127:69–80
- . Age-related effects on eyeblink conditioning in the F344 x BN F1 hybrid rat. Neurobiol. Aging. 2001;22:1–8
- . Extrasynaptic glutamate spillover in the hippocampus: evidence and implications. Trends Neurosci. 1998;21:8–14
- . Aging effects on the limits and stability of long-term synaptic potentiation and depression in rat hippocampal area CA1. J Neurophysiol. 2007;98:594–601
- . ‘Increased calcium-current’ hypothesis of brain aging. Neurobiol. Aging. 1987;8:346–347
- . Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature. 1995;375:400–404
- . Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nat. Neurosci. 2000;3:895–903
- . AMPA receptor trafficking and synaptic plasticity. Annu. Rev Neurosci. 2002;25:103–126
- . Synaptic efficacy and EPSP summation in granule cells of rat fascia dentate studied in vitro. J. Neurophysiol. 1981;46:952–966
- Nicholson, D.A., Geinisman, Y. Synaptic subtype-specific differences in structure, size, strength and connectivity in apical dendritic regions of rat hippocampal CA1 pyramidal neurons. J. Comp. Neurol., in press.
- . Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and age-related spatial learning impairments. J. Neurosci. 2004;24:7648–7653
- . Distance-dependent differences in synapse number and AMPA receptor expression in hippocampal CA1 pyramidal neurons. Neuron. 2006;50:431–442
- . Expression mechanisms underlying long-term potentiation: a postsynaptic view. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2003;358:721–726
- . Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron. 1998;21:545–559
- . Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses. Nat. Neurosci. 1999;2:31–36
- . NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area. J. Neurosci. 2000;20:2512–2522
- . Frequency-dependent shift from paired-pulse facilitation to paired-pulse depression at unitary CA3-CA3 synapses in the rat hippocampus. J. Physiol. 2002;544:469–476
- . Occurrence and three-dimensional structure of multiple synapses between individual radiatum axons and their target pyramidal cells in hippocampal area CA1. J. Neurosci. 1993;13:3736–3748
- . Structural and functional properties of hippocampal neurons. In: Andersen P, Morris RG, Amaral D, Bliss T, O’Keefe J editor. The Hippocampus Book. Oxford: Oxford University Press; 2007;p. 133–201
- . Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. J. Physiol. 1995;482:325–352
- . Facilitation and depression at single central synapses. Neuron. 1995;14:795–802
- . Different modes of expression of AMPA and NMDA receptors in hippocampal synapses. Nat. Neurosci. 1999;2:618–624
- . The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging. Aging Cell. 2007;6:267–273
- . Ca2+ regulation and gene expression in normal brain aging. Trends Neurosci. 2004;27:614–620
- . ‘Deaf, mute, and whispering’ silent synapses: their role in plasticity. J. Physiol. 2004;557:3–12
- . Postsynaptic depolarization enhances transmitter release and causes the appearance of responses at “silent” synapses in rat hippocampus. Neuroscience. 2004;126:45–59
- . Neurocognitive aging: prior memories hinder new hippocampal encoding. Trends Neurosci. 2006;29:662–670
- . Estrogen increases synaptic connectivity between single presynaptic inputs and multiple postsynaptic CA1 pyramidal cells: a serial electron- microscopic study. Proc. Natl. Acad. Sci. U.S.A. 2001;98:3525–3530
PII: S0197-4580(08)00206-6
doi: 10.1016/j.neurobiolaging.2008.05.029
© 2008 Elsevier Inc. All rights reserved.
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Neurobiology of Aging
Volume 31, Issue 5
, Pages 813-825
, May 2010
