Neurobiology of Aging
Volume 31, Issue 4 , Pages 636-646 , April 2010

Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model

  • Haiqun Jia

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Zhongbo Liu

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Xin Li

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • ,
  • Zhihui Feng

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Jiejie Hao

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Xuesen Li

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Weili Shen

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • ,
  • Hongyu Zhang

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • ,
  • Jiankang Liu

      Affiliations

    • Institute for Brain Aging and Dementia, University of California, 1261 Gillespie Neuroscience Research Facility, Irvine, CA 92697-4540, USA
    • Institute of Sports and Nutrition, College of Physical Education and Health, East China Normal University, Shanghai 200241, China
    • Corresponding Author InformationCorresponding author. Tel.: +1 949 824 9896; fax: +1 949 824 2071.

Received 11 July 2007 ,Revised 11 May 2008 ,Accepted 28 May 2008.

References 

  1. Alisky JM. Niacin improved rigidity and bradykinesia in a Parkinson's disease patient but also caused unacceptable nightmares and skin rash—a case report. Nutr. Neurosci. 2005;8(5–6):327–329
  2. Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. Am. J. Clin. Nutr. 2002;75(4):616–658
  3. Ames BN, Suh JH, Liu J. Enzymes lose binding affinity for coenzymes and substrates with age: a strategy for remediation. In:  Kaput J editors. Nutrigenomics: Concerpts and Technologies. Hoboken: NJ: John Wiley and Sons, Inc.; 2006;p. 277–291
  4. Anderson DW, Bradbury KA, Schneider JS. Neuroprotection in Parkinson models varies with toxin administration protocol. Eur. J. Neurosci. 2006;24(11):3174–3182
  5. Aruoma OI, Colognato R, Fontana I, Gartlon J, Migliore L, Koike K, et al. Molecular effects of fermented papaya preparation on oxidative damage, MAP Kinase activation and modulation of the benzo[a]pyrene mediated genotoxicity. Biofactors. 2006;26(2):147–159
  6. Beal MF. Bioenergetic approaches for neuroprotection in Parkinson's disease. Ann. Neurol. 2003;53(Suppl. 3):S39–S47discussion S-8
  7. Beal MF, Matthews RT, Tieleman A, Shults CW, Coenzyme . Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res. 1998;783(1):109–114
  8. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol. Rev. 1998;78(2):547–581
  9. Betarbet R, Sherer TB, Greenamyre JT. Animal models of Parkinson's disease. Bioessays. 2002;24(4):308–318
  10. Betarbet R, Sherer TB, Greenamyre JT. Ubiquitin-proteasome system and Parkinson's diseases. Exp. Neurol. 2005;191(Suppl. 1):S17–27
  11. Choo HJ, Kim JH, Kwon OB, Lee CS, Mun JY, Han SS, et al. Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabetologia. 2006;49(4):784–791
  12. Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell. 2006;127(1):59–69
  13. de Grey ADJ. The Mitochondrial Free Radical Theory of Aging. Georgetown. Texas: R.G. Landers Company; 1999;
  14. Ebadi M, Govitrapong P, Sharma S, Muralikrishnan D, Shavali S, Pellett L, et al. Ubiquinone (coenzyme Q10) and mitochondria in oxidative stress of Parkinson's disease. Biol. Signals Recept. 2001;10(3–4):224–253
  15. Flachs P, Horakova O, Brauner P, Rossmeisl M, Pecina P, Franssen-van Hal N, et al. Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. Diabetologia. 2005;48(11):2365–2375
  16. Frei B, Kim MC, Ames BN. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc. Natl. Acad. Sci. USA. 1990;87(12):4879–4883
  17. Gardner TS. The use of Drosophila melanogaster as a screening agent for longevity factors. II. The effects of biotin, pyridoxine, sodium yeast nucleate, and pantothenic acid on the life span of the fruit fly. J. Gerontol. 1948;1(3):9–13
  18. Glinka Y, Tipton KF, Youdim MB. Mechanism of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine and its prevention by desferrioxamine. Eur. J. Pharm. 1998;351(1):121–129
  19. Hagen TM, Yowe DL, Bartholomew JC, Wehr CM, Do KL, Park JY, et al. Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc. Natl. Acad. Sci. USA. 1997;94(7):3064–3069
  20. Hu ML, Chen YK, Lin YF. The antioxidant and prooxidant activity of some B vitamins and vitamin-like compounds. Chem. Biol. Interact. 1995;97(1):63–73
  21. Humphries KM, Szweda LI. Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry. 1998;37(45):15835–15841
  22. Kirsch M, De Groot H. NAD(P)H, a directly operating antioxidant?. FASEB J. 2001;15(9):1569–1574
  23. Langston JW. Current theories on the cause of Parkinson's disease. J. Neurol. Neurosurg. Psychiatry. 1989;Suppl.: 13–7
  24. Liu J, Ames BN. Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease. Nutr. Neurosci. 2005;8(2):67–89
  25. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-l-carnitine and/or R-alpha-lipoic acid. Proc. Natl. Acad. Sci. USA. 2002;99(4):2356–2361
  26. Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l-carnitine and/or R-alpha-lipoic acid. Proc. Natl. Acad. Sci. USA. 2002;99(4):1876–1881
  27. Liu Y, Fiskum G, Schubert D. Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 2002;80(5):780–787
  28. McCarty MF. Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity. Med. Hypotheses. 2005;64(2):399–407
  29. Olive PL, Durand RE. Heterogeneity in DNA damage using the Comet assay. Cytometry A. 2005;66(1):1–8
  30. Olive PL, Banath JP, Durand RE. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the “comet” assay. Radiat. Res. 1990;122(1):86–94
  31. Parker WD, Swerdlow RH. Mitochondrial dysfunction in idiopathic Parkinson disease. Am. J. Hum. Genet. 1998;62(4):758–762
  32. Poon HF, Frasier M, Shreve N, Calabrese V, Wolozin B, Butterfield DA. Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice—a model of familial Parkinson's disease. Neurobiol. Dis. 2005;18(3):492–498
  33. Shamoto-Nagai M, Maruyama W, Kato Y, Isobe K, Tanaka M, Naoi M, et al. An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells. J. Neurosci. Res. 2003;74(4):589–597
  34. Shea TB, Ekinci FJ, Ortiz D, Dawn-Linsley M, Wilson TO, Nicolosi RJ. Efficacy of vitamin E, phosphatidyl choline, and pyruvate on buffering neuronal degeneration and oxidative stress in cultured cortical neurons and in central nervous tissue of apolipoprotein E-deficient mice. Free Radic. Biol. Med. 2002;33(2):276–282
  35. Shea TB, Ekinci FJ, Ortiz D, Wilson TO, Nicolosi RJ. Efficacy of vitamin E, phosphatidyl choline and pyruvate on Abeta neurotoxicity in culture. J. Nutr. Health Aging. 2003;7(4):252–255
  36. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, et al. R-alpha-Lipoic acid and acetyl-l-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. Diabetologia. 2008;51(1):165–174
  37. Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, et al. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J. Neurosci. 2002;22(16):7006–7015
  38. Sherer TB, Kim JH, Betarbet R, Greenamyre JT. Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Exp. Neurol. 2003;179(1):9–16
  39. Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. USA. 1994;91:10771–10778
  40. Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch. Neurol. 2002;59(10):1541–1550
  41. Smiley ST, Reers M, Mottola-Hartshorn C, Lin M, Chen A, Smith TW, et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc. Natl. Acad. Sci. USA. 1991;88(9):3671–3675
  42. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jager S, et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 2006;127(2):397–408
  43. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, et al. Single cell gel/Comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000;35(3):206–221
  44. Tirosh O, Sen CK, Roy S, Packer L. Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death. Neuroscience. 2000;97(3):531–541
  45. Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, et al. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J. Biol. Chem. 2005;280(52):42655–42668
  46. Veurink G, Liu D, Taddei K, Perry G, Smith MA, Robertson TA, et al. Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free Radic. Biol. Med. 2003;34(8):1070–1077
  47. Zhang, H., Jia, H., Liu, J.H., Ao, N., Yan, B., Shen, W., Wang, X., Li, X., Luo, C., Liu, J., 2008. Combined R-α–lipoic acid and acetyl-l-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease J. Cell Mol. Med., in press.

PII: S0197-4580(08)00181-4

doi: 10.1016/j.neurobiolaging.2008.05.031

Neurobiology of Aging
Volume 31, Issue 4 , Pages 636-646 , April 2010

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