Neurobiology of Aging
Volume 31, Issue 3 , Pages 409-415 , March 2010

Genetic association to the amyloid plaque associated protein gene COL25A1 in Alzheimer's disease

  • Charlotte Forsell

      Affiliations

    • Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KASPAC, Novum, S-141 57 Huddinge, Sweden
    • These authors contributed equally to the work.
    • ,
  • Behnosh Fakhri Björk

      Affiliations

    • Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI-Alzheimer Disease Research Center, Novum, S-141 57 Huddinge, Sweden
    • These authors contributed equally to the work.
    • ,
  • Lena Lilius

      Affiliations

    • Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KASPAC, Novum, S-141 57 Huddinge, Sweden
    • ,
  • Karin Axelman

      Affiliations

    • Karolinska University Hospital Huddinge, Department of Geriatric Medicine, S-141 86 Stockholm, Sweden
    • ,
  • Susanne Froelich Fabre

      Affiliations

    • Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KASPAC, Novum, S-141 57 Huddinge, Sweden
    • ,
  • Laura Fratiglioni

      Affiliations

    • Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Aging Research Center and Gerontology Research Center, S-113 30 Stockholm, Sweden
    • ,
  • Bengt Winblad

      Affiliations

    • Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KASPAC, Novum, S-141 57 Huddinge, Sweden
    • ,
  • Caroline Graff

      Affiliations

    • Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KASPAC, Novum, S-141 57 Huddinge, Sweden
    • Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI-Alzheimer Disease Research Center, Novum, S-141 57 Huddinge, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 8 585 83619; fax: +46 8 585 83610.

Received 27 August 2007 ,Revised 25 March 2008 ,Accepted 14 April 2008.

References 

  1. Atwood CS, Martins RN, Smith MA, Perry G. Senile plaque composition and posttranslational modification of amyloid-b peptide and associated proteins. Peptides. 2002;23:1343–1350
  2. Commenges D, Letenneur L, Joly P, Alioum A, Dartigues JF. Modelling age-specific risk: application to dementia. Stat. Med. 1998;17:1973–1988
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  8. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the nincds-ardra work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology. 1984;34:939–944
  9. Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo T. Clac binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. J. Biol. Chem. 2005;280:8596–8605
  10. Sillén A, Forsell C, Lilius L, Axelman K, Björk BF, Onkamo P, et al. Genome scan on Swedish Alzheimer's disease families. Mol. Psychiatry. 2006;11:182–186
  11. Sillén A, Andrade J, Lilius L, Forsell C, Axelman K, Odeberg J, et al. Expanded high-resolution genetic study of 109 Swedish families with Alzheimer's disease. Eur. J. Hum. Genet. 2008;16:202–208
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  13. Söderberg L, Dahlqvist C, Kakuyama H, Thyberg J, Ito A, Winblad B, et al. Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates. FEBS J. 2005;272:2231–2236
  14. Söderberg L, Kakuyama H, Möller A, Ito A, Winblad B, Tjernberg LO, et al. Characterization of the Alzheimer's disease-associated clac protein and identification of an amyloid b-peptid-binding site. J. Biol. Chem. 2005;280:1007–1015
  15. Söderberg L, Bogdanovic N, Axelsson B, Winblad B, Näslund J, Tjernberg LO. Analysis of single Alzheimer solid plaque cores by laser capture microscopy and nanoelectrospray/tandem mass spectrometry. Biochemistry. 2006;45:9849–9856

PII: S0197-4580(08)00135-8

doi: 10.1016/j.neurobiolaging.2008.04.009

Neurobiology of Aging
Volume 31, Issue 3 , Pages 409-415 , March 2010

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