Neurobiology of Aging
Volume 29, Issue 8 , Pages 1127-1132 , August 2008

No disease in the brain of a 115-year-old woman

  • Wilfred F.A. den Dunnen

      Affiliations

    • Department of Pathology and Medical Biology, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    • ,
  • Wiebo H. Brouwer

      Affiliations

    • Department of Neurology, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    • ,
  • Eveline Bijlard

      Affiliations

    • Center for Uroneurology, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    • ,
  • Jeanine Kamphuis

      Affiliations

    • Center for Uroneurology, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    • ,
  • Klaas van Linschoten

      Affiliations

    • Department of Anatomy, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    • ,
  • Ellie Eggens-Meijer

      Affiliations

    • Department of Anatomy, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    • ,
  • Gert Holstege

      Affiliations

    • Center for Uroneurology, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 50 363 2456; fax: +31 50 363 8214.

Received 10 April 2008 ,Revised 14 April 2008 ,Accepted 15 April 2008.

References 

  1. Berzlanovich AM, Keil W, Waldhoer T, Sim E, Fasching P, Fazeny-Dorner B. Do centenarians die healthy? An autopsy study. J. Gerontol. A: Biol. Sci. Med. Sci. 2005;60(7):862–865
  2. Braak H, Braak E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol. Aging. 1995;16(3):271–278
  3. Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol. Aging. 1997;18(4):351–357
  4. Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, et al. Neuropathology of cognitively normal elderly. J. Neuropathol. Exp. Neurol. 2003;62(11):1087–1095
  5. Manaye KF, McIntire DD, Mann DM, German DC. Locus coeruleus cell loss in the aging human brain: a non-random process. J. Comp. Neurol. 1995;358(1):79–87
  6. Vijayashankar N, Brody H. A quantitative study of the pigmented neurons in the nuclei locus coeruleus and subcoeruleus in man as related to aging. J. Neuropathol. Exp. Neurol. 1979;38(5):490–497

PII: S0197-4580(08)00134-6

doi: 10.1016/j.neurobiolaging.2008.04.010

Neurobiology of Aging
Volume 29, Issue 8 , Pages 1127-1132 , August 2008

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