Neurobiology of Aging
Volume 30, Issue 12 , Pages 1910-1917 , December 2009

The pathological interaction between diabetes and presymptomatic Alzheimer's disease

  • Joseph R. Burdo

      Affiliations

    • Cellular Neurobiology Laboratory, The Salk Institute For Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA
    • ,
  • Qi Chen

      Affiliations

    • Cellular Neurobiology Laboratory, The Salk Institute For Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA
    • ,
  • Nigel A. Calcutt

      Affiliations

    • Department of Pathology, University of California at San Diego, La Jolla, CA 92093-0612, USA
    • ,
  • David Schubert

      Affiliations

    • Cellular Neurobiology Laboratory, The Salk Institute For Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 858 453 4100x1528; fax: +1 858 535 9062.

Received 10 November 2007 ,Revised 29 January 2008 ,Accepted 19 February 2008.

References 

  1. Arvanitakis Z, Wilson RS, Bienias JL, Evans DA, Bennett DA. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch. Neurol. 2004;61:661–666
  2. Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell. 1994;77:817–827
  3. Biessels GJ, Bravenboer B, Gispen WH. Glucose, insulin and the brain—modulation of cognition and synaptic plasticity in health and disease: a preface. Eur. J. Pharmacol. 2004;490:1–4
  4. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006;5:64–74
  5. Brands AM, Biessels GJ, Kappelle LJ, de Haan EH, de Valk HW, Algra A, et al. Cognitive functioning and brain MRI in patients with type 1 and type 2 diabetes mellitus: a comparative study. Dement. Geriatr. Cogn. Disorders. 2007;23:343–350
  6. Burdo JR, Simpson IA, Menzies S, Beard J, Connor JR. Regulation of the profile of iron-management proteins in brain microvasculature. J. Cereb. Blood Flow Metab. 2004;24:67–74
  7. Chibber R, Molinatti PA, Rosatto N, Lambourne B, Kohner EM. Toxic action of advanced glycation end products on cultured retinal capillary pericytes and endothelial cells: relevance to diabetic retinopathy. Diabetologia. 1997;40:156–164
  8. Choeiri C, Hewitt K, Durkin J, Simard CJ, Renaud JM, Messier C. Longitudinal evaluation of memory performance and peripheral neuropathy in the Ins2C96Y Akita mice.. Behav. Brain Res. 2005;157:31–38
  9. Das P, Parsons AD, Scarborough J, Hoffman J, Wilson J, Thompson RN, et al. Electrophysiological and behavioral phenotype of insulin receptor defective mice. Physiol. Behav. 2005;86:287–296
  10. Gentile MT, Vecchione C, Maffei A, Aretini A, Marino G, Poulet R, et al. Mechanisms of soluble beta-amyloid impairment of endothelial function. J. Biol. Chem. 2004;279:48135–48142
  11. Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 1984;120:885–890
  12. Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation. 2006;114:597–605
  13. Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Shulman RG. 1H NMR studies of glucose transport in the human brain. J. Cereb. Blood Flow Metab. 1996;16:427–438
  14. Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch. Neurol. 2003;60:1119–1122
  15. Heneka MT, Sastre M, Dumitrescu-Ozimek L, Dewachter I, Walter J, Klockgether T, et al. Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J. Neuroinflammat. 2005;2:22
  16. Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, et al. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J. 2004;18:902–904
  17. Huang HJ, Liang KC, Chen CP, Chen CM, Hsieh-Li HM. Intrahippocampal administration of A beta(1–40) impairs spatial learning and memory in hyperglycemic mice. Neurobiol. Learn. Mem. 2007;87:483–494
  18. Jankowsky JL, Younkin LH, Gonzales V, Fadale DJ, Slunt HH, Lester HA, et al. Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. J. Biol. Chem. 2007;282:22707–22720
  19. Li ZG, Zhang W, Sima AA. Alzheimer-like changes in rat models of spontaneous diabetes. Diabetes. 2007;56:1817–1824
  20. Lovell MA, Markesbery WR. Oxidative damage in mild cognitive impairment and early Alzheimer's disease. J. Neurosci. Res. 2007;85:3036–3040
  21. Minkeviciene R, Banerjee P, Tanila H. Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease. J. Pharmacol. Exp. Ther. 2004;311:677–682
  22. Mohmmad Abdul H, Wenk GL, Gramling M, Hauss-Wegrzyniak B, Butterfield DA. APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's disease. Neurosci. Lett. 2004;368:148–150
  23. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods. 1984;11:47–60
  24. Muriach M, Bosch-Morell F, Alexander G, Blomhoff R, Barcia J, Arnal E, et al. Lutein effect on retina and hippocampus of diabetic mice. Free Radic. Biol. Med. 2006;41:979–984
  25. Muruganandam A, Herx LM, Monette R, Durkin JP, Stanimirovic DB. Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood–brain barrier. FASEB J. 1997;11:1187–1197
  26. Rodriguez-Manas L, Angulo J, Vallejo S, Peiro C, Sanchez-Ferrer A, Cercas E, et al. Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature. Diabetologia. 2003;46:556–566
  27. Rolo AP, Palmeira CM. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol. Appl. Pharmacol. 2006;212:167–178
  28. Saxena G, Singh SP, Pal R, Singh S, Pratap R, Nath C. Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice. Pharmacol. Biochem. Behav. 2007;86:797–805
  29. Takahashi H, Mizui T, Shirao T. Down-regulation of drebrin A expression suppresses synaptic targeting of NMDA receptors in developing hippocampal neurones. J Neurochem. 2006;97(Suppl. 1):110–115
  30. Vlassara H, Palace MR. Glycoxidation: the menace of diabetes and aging. Mt. Sinai J. Med. 2003;70:232–241
  31. Xie W, Du L. High-cholesterol diets impair short-term retention of memory in alloxan-induced diabetic mice, but not acquisition of memory nor retention of memory in prediabetic mice. Life Sci. 2005;77:481–495
  32. Xu J, Chen S, Ku G, Ahmed SH, Xu J, Chen H, et al. Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation. J. Cereb. Blood Flow Metab. 2001;21:702–710
  33. Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, et al. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat. Neurosci. 2006;9:234–242
  34. Zhou Q, Homma KJ, Poo MM. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron. 2004;44:749–757

PII: S0197-4580(08)00059-6

doi: 10.1016/j.neurobiolaging.2008.02.010

Neurobiology of Aging
Volume 30, Issue 12 , Pages 1910-1917 , December 2009

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