« Previous
Next »
Neurobiology of Aging
Volume 30, Issue 11
, Pages 1756-1776
, November 2009
Synaptic contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic mice
References
- . Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiol. Dis. 2005;20(2):187–198
- . Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint. J. Neurosci. 2005;25(25):5943–5955
- . Exponentially decreasing distributions for the logarithm of particle size. Proc. Roy. Soc. Lond. A. 1977;353:401–419
- . Altered synaptic function in Alzheimers disease. Eur. J. Pharmacol. 2006;545:11–21
- Blæsild, P., Sørensen, M.K., 1992. Letter to Anonymous.
- . Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice. Exp. Neurol. 2003;184(1):247–263
- . Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice. Neurobiol. Aging. 2005;26(5):607–613
- . Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1–42/1–40 ratio in vitro and in vivo. Neuron. 1996;17(5):1005–1013
- . Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am. J. Pathol. 2004;165(4):1289–1300
- . Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron. 2005;48(6):913–922
- . A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology. 2004;63(7):1155–1162
- . Synaptic slaughter in Alzheimer's disease. Neurobiol. Aging. 2003;24(8):1023–1027
- . A general variance predictor for Cavalieri slices. J. Microsc. 2006;222(Pt 3):158–165
- . Comparison of methods for estimation of the thickness of ultrathin tissue sections. J. Microsc. 1988;151:23–42
- . Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein
+
presenilin-1 transgenic mice. J. Neurosci. 2003;23(12):5219–5226 - . Building a more perfect beast: APP transgenic mice with neuronal loss. Am. J. Pathol. 2004;164(4):1143–1146
- . Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice. J. Comp. Neurol. 2007;500(2):311–321
- . Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Hum. Mol. Genet. 2005;14(3):447–460
- . An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity. Neurobiol. Dis. 2006;23(3):669–678
- . Cylindrical diameters method for calibrating section thickness in serial electron microscopy. J. Microsc. 2001;202(Pt 3):468–472
- . Extending unbiased stereology of brain ultrastructure to three-dimensional volumes. J. Am. Med. Inform. Assoc. 2001;8(1):1–16
- . Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. J. Cell. Mol. Med. 2006;10(3):796–805
- . Differences in the expression of AMPA and NMDA receptors between axospinous perforated and nonperforated synapses are related to the configuration and size of postsynaptic densities. J. Comp. Neurol. 2004;468(1):86–95
- . Synapses with a segmented, completely partitioned postsynaptic density express more AMPA receptors than other axospinous synaptic junctions. Neuroscience. 2004;125(3):615–623
- . Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum. Neurobiol. Aging. 2007;25:407–416
- . Unbiased stereological estimation of the total number of synapses in a brain region. J. Neurocytol. 1996;25(12):805–819
- . Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol. Aging. 2006;27(4):570–575
- . Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease. Arch. Neurol. 2007;64(3):354–362
- . Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease. Ann. NY Acad. Sci. 2007;1097:30–39
- . Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones. J. Microsc. 1986;143:3–45
- . The efficiency of systematic sampling in stereology—reconsidered. J. Microsc. 1999;193(Pt 3):199–211
- . Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell. Biol. 2007;8(2):101–112
- . Alzheimer's disease: the amyloid cascade hypothesis. Science. 1992;256(5054):184–185
- . Uniform serial sectioning for transmission electron microscopy. J. Neurosci. 2006;26(47):12101–12103
- . Principles and Techniques of Electron Microscopy, Biological Applications. New York: Van Nostrand Reinhold; 1970;
- . siRNA targeted against amyloid precursor protein impairs synaptic activity in vivo. Neurobiol. Aging. 2006;27(12):1740–1750
- . Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc. Natl. Acad. Sci. U.S.A. 1999;96(6):3228–3233
- . AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 2006;52(5):831–843
- Iacono, D., O’Brian, R., Resnik, S.M., Zonderman, A.B., Pletnikova, O., Rudow, G., West, M.J., Crain, B., Troncoso, J., submitted for publication. Neuronal hypertrophy in asymptomatic Alzheimer's disease.
- . Visualization of Abeta42(43) and Abeta40 in senile plaques with end-specific Abeta monoclonals: evidence that an initially deposited species is Abeta 42(43). Neuron. 1994;13:45–53
- . Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2006;103(13):5161–5166
- . Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum. Mol. Genet. 2004;13(2):159–170
- . Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol. Eng. 2001;17(6):157–165
- . APP processing and synaptic function. Neuron. 2003;37(6):925–937
- . Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003;300(5618):486–489
- . Beta-amyloid disrupted synaptic vesicle endocytosis in cultured hippocampal neurons. Neuroscience. 2007;147:60–70
- . Abeta40 inhibits amyloid deposition in vivo. J. Neurosci. 2007;27(3):627–633
- . Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J. Neurosci. 2007;27(4):796–807
- . A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006;440(7082):352–357
- . Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice. Neurobiol. Aging. 2006;
- . An alternative interpretation of the amyloid Abeta hypothesis with regard to the pathogenesis of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2005;102(26):9093–9098
- . Synaptic remodeling during aging and in Alzheimer's disease. J. Alzheimers Dis. 2006;9(3 Suppl.):91–99
- . Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J. Neurosci. 1996;16(18):5795–5811
- . Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience. 1997;78(1):135–146
- . Editorial introduction to papers. J. Microsc. 2006;222:143–145
- . Prediction of the variance of stereological volume estimates from systematic sections using computer-intensive methods. J. Microsc. 2006;222(Pt 3):166–176
- . Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol. Rev. 1997;77(4):1081–1132
- . A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet. 2006;22(5):281–289
- . Array tomography: a new tool for imaging the molecular architecture and ultrastructure of neural circuits. Neuron. 2007;55(1):25–36
- . Dendrite and dendritic spine alterations in Alzheimer models. J. Neurocytol. 2004;33(3):377–387
- . Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice.. Brain Res. 1994;666(2):151–167
- . High-level neuronal expression of abeta 1–42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 2000;20(11):4050–4058
- . Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 1998;21(5):1213–1221
- . Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and age-related spatial learning impairments. J. Neurosci. 2004;24(35):7648–7653
- . Direct and efficient stereological estimation of total cell quantities using electron microscopy. J. Microsc. 2006;222(Pt 3):182–187
- . A dynamic relationship between intracellular and extracellular pools of Abeta. Am. J. Pathol. 2006;168(1):184–194
- . Amyloid precurser protein increases cortical neuron size in transgenic mice. Neurobiol. Aging. 2009;30:1238–1244
- . Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice. J. Neurosci. 2005;25(42):9686–9693
- . A network dysfunction perspective on neurodegenerative diseases. Nature. 2006;443(7113):768–773
- . Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice. J. Neurosci. 2005;25(44):10220–10229
- . Mutant presenilin 1 alters synaptic transmission in cultured hippocampal neurons. J. Biol. Chem. 2007;282(2):1119–1127
- . Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc. Natl. Acad. Sci. U.S.A. 2003;100(3):1381–1386
- . Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor. Proc. Natl. Acad. Sci. U.S.A. 1994;91(16):7450–7454
- . Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease. J. Biol. Chem. 1993;268(5):3072–3083
- . Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses. J. Neurosci. 2005;25(48):11061–11070
- . Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice. Am. J. Pathol. 2005;167(1):161–173
- . Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neurosci. Res. 2006;54(4):235–253
- . Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006;51(1):29–42
- . Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies. Neurobiol. Aging. 2003;24(8):1029–1046
- . Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology. 2007;68(18):1501–1508
- . Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol. Aging. 2006;27(10):1372–1384
- . Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am. J. Pathol. 2004;164(4):1495–1502
- . Alzheimer's disease is a synaptic failure. Science. 2002;298(5594):789–791
- . The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc. Natl. Acad. Sci. U.S.A. 2007;104(2):403–409
- . Cerebrospinal fluid Abeta40 and Abeta42: natural course and clinical usefulness. J. Alzheimers Dis. 2001;3(3):313–321
- . Proteomic analysis of brain tissue from an Alzheimer's disease mouse model by two-dimensional difference gel electrophoresis. Neurobiol. Aging. 2007;28(3):357–370
- . Estimators of the precision of stereological estimates: an example based on the CA1 pyramidal cell layer of rats. Neuroscience. 2005;136(3):757–767
- . Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals. Cell Calcium. 2005;38(3/4):427–437
- . Regulation of NMD A receptor trafficking by amyloid-beta. Nat. Neurosci. 2005;8(8):1051–1058
- . Transgenic models of Alzheimer's disease: learning from animals. NeuroRx. 2005;2(3):423–437
- . Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J. Neurosci. 2005;25(31):7278–7287
- . Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways. J. Neurosci. 2002;22(17):7380–7388
- . Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005;307(5713):1282–1288
- . Proteomics analysis of the Alzheimer's disease hippocampal proteome. J. Alzheimer's Dis. 2007;11:153–164
- . Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. Am. J. Pathol. 2000;157(1):331–339
- . Total regional and global number of synapses in the human brain neocortex. Synapse. 2001;41(3):258–273
- . The synaptic Abeta hypothesis of Alzheimer disease. Nat. Neurosci. 2005;8(8):977–979
- . Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell. 2005;120(4):545–555
- . Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Annu. Rev. Physiol. 1991;30:572–580
- . Neuroplasticity in Alzheimer's disease. J. Neurosci. Res. 2002;70(3):402–437
- . Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 1996;17(1):181–190
- . Alzheimer disease: the calcium conspiracy. Nat. Neurosci. 2006;9(11):1354–1355
- . The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction. J. Neurosci. 1999;19(18):7793–7803
- . Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell. 2006;126(5):981–993
- . Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice. Neurobiol. Dis. 2006;23(3):653–662
- . Stereology meets electron tomography: towards quantitative 3D electron microscopy. J. Struct. Biol. 2007;159(3):443–450
- . Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis. J. Neurosci. 2007;27:6771–6780
- . New stereological methods for counting neurons. Neurobiol. Aging. 1993;14(4):275–285
- . Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends Neurosci. 1999;22(2):51–61
- . Differences in the pattern of neuronal loss in normal aging and Alzheimer's disease. Lancet. 1994;244:769–772
- . Hippocampal neurons in pre-clinical Alzheimer's disease. Neurobiol. Aging. 2004;25(9):1205–1212
- . Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 1991;231:482–497
- . Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci. Lett. 2001;306(1/2):116–120
- . Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol. Aging. 2007;28:1689–1699
- . A new fractionator principle with varying sampling fractions: exemplified by estimation of synapse number using electron microscopy. J. Microsc. 2006;222(Pt 3):251–255
PII: S0197-4580(08)00024-9
doi: 10.1016/j.neurobiolaging.2008.01.009
© 2008 Elsevier Inc. All rights reserved.
« Previous
Next »
Neurobiology of Aging
Volume 30, Issue 11
, Pages 1756-1776
, November 2009
