Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice

Bernardo, Alexandra; Harrison, Fiona E.; McCord, Meghan; Zhao, Jiali; Bruchey, Aleksandra; Davies, Sean S.; Jackson Roberts, L.; Mathews, Paul M.; Matsuoka, Yasuji; Ariga, Toshio; Yu, Robert K.; Thompson, Rebecca; McDonald, Michael P.

doi:10.1016/j.neurobiolaging.2007.12.022

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Volume 30, Issue 11 , Pages 1777-1791, November 2009

Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice

Alexandra Bernardo
- Department of Pharmacology, Vanderbilt University, Nashville, TN, United States
- Program in Neuroscience, Vanderbilt University, Nashville, TN, United States
Fiona E. Harrison
- Department of Pharmacology, Vanderbilt University, Nashville, TN, United States
- Program in Neuroscience, Vanderbilt University, Nashville, TN, United States
Meghan McCord
- Program in Neuroscience, Vanderbilt University, Nashville, TN, United States
Jiali Zhao
- Department of Pharmacology, Vanderbilt University, Nashville, TN, United States
Aleksandra Bruchey
- Program in Neuroscience, Vanderbilt University, Nashville, TN, United States
Sean S. Davies
- Department of Pharmacology, Vanderbilt University, Nashville, TN, United States
L. Jackson Roberts II
- Department of Pharmacology, Vanderbilt University, Nashville, TN, United States
Paul M. Mathews
- Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Department of Psychiatry, New York University Medical Center, Orangeburg, NY, United States
Yasuji Matsuoka
- Department of Neurology, Georgetown University, Washington, DC, United States
Toshio Ariga
- Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, Augusta, GA, United States
Robert K. Yu
- Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, Augusta, GA, United States
Rebecca Thompson
- Program in Neuroscience, Vanderbilt University, Nashville, TN, United States
Michael P. McDonald
- Department of Pharmacology, Vanderbilt University, Nashville, TN, United States
- Program in Neuroscience, Vanderbilt University, Nashville, TN, United States
- Departments of Neurology and Anatomy & Neurobiology, University of Tennessee Health Science Center, Memphis, TN, United States
- Corresponding author at: University of Tennessee Health Science Center, 855 Monroe Avenue, Link Building, Room 415, Memphis, TN 38163, United States. Tel.: +1 901 448 4648.