Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

Karuppagounder, Saravanan S.; Xu, Hui; Shi, Qingli; Chen, Lian H.; Pedrini, Steve; Pechman, David; Baker, Harriet; Beal, M. Flint; Gandy, Sam E.; Gibson, Gary E.

doi:10.1016/j.neurobiolaging.2007.12.013

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Volume 30, Issue 10 , Pages 1587-1600, October 2009

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

Saravanan S. Karuppagounder
- Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, United States
Hui Xu
- Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, United States
Qingli Shi
- Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, United States
Lian H. Chen
- Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, United States
Steve Pedrini
- Thomas Jefferson University, Farber Institute for the Neurosciences, 900 Walnut Street, Suite 467, Philadelphia, PA 19107, United States
David Pechman
- Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, United States
Harriet Baker
- Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, United States
M. Flint Beal
- Department of Neurology and Neurosciences, Weill Medical College of Cornell University, 525E, 68th Street, New York, NY 10021, United States
Sam E. Gandy
- Thomas Jefferson University, Farber Institute for the Neurosciences, 900 Walnut Street, Suite 467, Philadelphia, PA 19107, United States
Gary E. Gibson
- Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, United States
- Corresponding author. Tel.: +1 914 597 2291; fax: +1 914 597 2757.