Neurobiology of Aging
Volume 30, Issue 9 , Pages 1413-1419 , September 2009

Prefrontal cortex atrophy predicts dementia over a six-year period

  • S. Burgmans

      Affiliations

    • Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • European Graduate School of Neuroscience (EURON), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author at: Department of Psychiatry and Neuropsychology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands Tel.: +31 43 3881942; fax: +31 43 3884092.
    • ,
  • M.P.J. van Boxtel

      Affiliations

    • Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • European Graduate School of Neuroscience (EURON), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • ,
  • F. Smeets

      Affiliations

    • Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • European Graduate School of Neuroscience (EURON), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • ,
  • E.F.P.M. Vuurman

      Affiliations

    • Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • European Graduate School of Neuroscience (EURON), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • ,
  • E.H.B.M. Gronenschild

      Affiliations

    • Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • European Graduate School of Neuroscience (EURON), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • ,
  • F.R.J. Verhey

      Affiliations

    • Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • European Graduate School of Neuroscience (EURON), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • ,
  • H.B.M. Uylings

      Affiliations

    • Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • Department of Anatomy and Neuroscience, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    • European Graduate School of Neuroscience (EURON), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • ,
  • J. Jolles

      Affiliations

    • Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • European Graduate School of Neuroscience (EURON), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands

Received 13 July 2007 ,Revised 10 October 2007 ,Accepted 26 November 2007.

References 

  1. APA . Diagnostic and Statistical Manual of Mental Disorders IV. Washington, DC: American Psychiatric Associations; 1994;
  2. De la Torre JC. Alzheimer disease as a vascular disorder: nosological evidence. Stroke. 2002;33(4):1152–1162
  3. DeCarli C, Frisoni GB, Clark CM, Harvey D, Grundman M, Petersen RC, et al. Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia. Arch. Neurol. 2007;64(1):108–115
  4. Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, et al. MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. AJNR Am. J. Neuroradiol. 1998;19(4):659–671
  5. Jolles J, Houx PJ, Van Boxtel MPJ, Ponds RWHM. Maastricht Aging Study: Determinants of Cognitive Aging. Maastricht: Neuropsych Publishers; 1995;
  6. Jones BF, Barnes J, Uylings HBM, Fox NC, Frost C, Witter MP, et al. Differential regional atrophy of the cingulate gyrus in Alzheimer disease: a volumetric MRI study. Cereb. Cortex. 2006;16(12):1701–1708
  7. Korf ES, Wahlund LO, Visser PJ, Scheltens P. Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment. Neurology. 2004;63(1):94–100
  8. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 1984;34(7):939–944
  9. Nyúl LG, Udupa JK. On standardizing the MR image intensity scale. Magn. Reson. Med. 1999;42(6):1072–1081
  10. Persson J, Nyberg L, Lind J, Larsson A, Nilsson LG, Ingvar M, et al. Structure-function correlates of cognitive decline in aging. Cereb. Cortex. 2006;16(7):907–915
  11. Raz N. Aging of the brain and its impact on cognitive performance: Integration of structural and functional findings. In:  Craik FIM,  Salthouse TA editor. The Handbook of Aging and Cognition. Mahwah, NJ: Lawrence Erlbaum Associates; 2000;
  12. Raz N, Lindenberger U, Rodrigue KM, Kennedy KM, Head D, Williamson A, et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb. Cortex. 2005;15(11):1676–1689
  13. Salat DH, Kaye JA, Janowsky JS. Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease. Arch. Neurol. 1999;56(3):338–344
  14. Salat DH, Kaye JA, Janowsky JS. Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer disease. Arch. Neurol. 2001;58(9):1403–1408
  15. Shrout PE, Fleiss JL. Intraclass correlations: uses in assessing rater reliability. Psychol. Bull. 1979;2:420–428
  16. Sled JG, Zijdenbos AP, Evans AC. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans. Med. Imaging. 1998;17(1):87–97
  17. Tisserand DJ, Pruessner JC, Sanz Arigita EJ, Van Boxtel MP, Evans AC, Jolles J, et al. Regional frontal cortical volumes decrease differentially in aging: an MRI study to compare volumetric approaches and voxel-based morphometry. Neuroimage. 2002;17(2):657–669
  18. Tisserand DJ, Van Boxtel MP, Pruessner JC, Hofman P, Evans AC, Jolles J. A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time. Cereb. Cortex. 2004;14(9):966–973
  19. Uylings HBM, Malofeeva LI, Bogolepova IN, Jacobsen AM, Amunts K, Zilles K. No postnatal doubling of number of neurons in human Broca's areas (Brodmann areas 44 and 45)? A stereological study. Neuroscience. 2005;136(3):715–728
  20. Van Boxtel MP, Buntinx F, Houx PJ, Metsemakers JF, Knottnerus A, Jolles J. The relation between morbidity and cognitive performance in a normal aging population. J. Gerontol. A. Biol. Sci. Med. Sci. 1998;53(2):M147–M154
  21. Van den Brandt PA, Goldbohm RA, Van ’t Veer P, Volovics A, Hermus RJ, Sturmans F. A large-scale prospective cohort study on diet and cancer in the Netherlands. J. Clin. Epidemiol. 1990;43(3):285–295
  22. Visser PJ, Scheltens P, Verhey FR, Schmand B, Launer LJ, Jolles J, et al. Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment. J. Neurol. 1999;246(6):477–485
  23. Visser PJ, Verhey FR, Hofman PA, Scheltens P, Jolles J. Medial temporal lobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment. J. Neurol. Neurosurg. Psychiatry. 2002;72(4):491–497
  24. Zijdenbos AP, Forghani R, Evans AC. Automatic “pipeline” analysis of 3-D MRI data for clinical trials: application to multiple sclerosis. IEEE Trans. Med. Imag. 2002;21(10):1280–1291

PII: S0197-4580(07)00457-5

doi: 10.1016/j.neurobiolaging.2007.11.028

Neurobiology of Aging
Volume 30, Issue 9 , Pages 1413-1419 , September 2009

Article Tools

* Image Usage & Resolution