« Previous
Next »
Neurobiology of Aging
Volume 30, Issue 9
, Pages 1379-1392
, September 2009
Amyloid-β precursor protein mediates neuronal toxicity of amyloid β through Go protein activation
References
- . Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature. 2004;431(7010):805–810
- . Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant Presenilin 1 and amyloid precursor proteins. Neuron. 1997;19:939–945
- . The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction. J. Neurosci. 1999;19(5):1717–1727
- . Methodological variables in the assessment of beta amyloid neurotoxicity. Neurobiol. Aging. 1992;13:609–612
- . Beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron. 1995;14:879–888
- . Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 1991;88(17):7552–7556
- . Amyloid β-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. J. Neurochem. 1995;65:931–934
- . Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J. Neurosci. 2006;26(22):6011–6018
- . Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature. 1996;382(6593):716–719
- . Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc. Natl. Acad. Sci. U.S.A. 2006;103(18):7130–7135
- . G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO J. 1997;16(16):4897–4907
- . Aberrant activation of focal adhesion proteins mediates fibrillar amyloid β-induced neuronal dystrophy. J. Neurosci. 2003;23:493–502
- . The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002;297(5580):353–356
- . Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein. Mol. Cell. Biol. 2005;25(21):9304–9317
- . Multiple mechanisms underlie neurotoxicity by different types of Alzheimeŕs disease mutations of amyloid precursor protein. J. Biol. Chem. 2000;275(44):34541–34551
- . Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death. J. Neurochem. 2003;84:864–877
- . Phosphorylation of ADF/Cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimeŕs disease. J. Neurosci. 2006;26(24):6533–6542
- . Amyloid beta-induced neurodegeneration promotes cell surface accumulation of amyloid-beta precursor protein. Neurobiol. Dis. 2004;16(3):617–629
- . Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003;300:486–489
- . Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. U.S.A. 1998;95(11):6448–6453
- . Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc. Natl. Acad. Sci. U.S.A. 1994;91:12243–12247
- . Amyloid beta interacts with amyloid precursor protein: a potential toxic mechanism in Alzheimeŕs disease. Nat. Neurosci. 2000;3:460–464
- . A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat. Med. 2000;6(4):397–404
- . Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann. Neurol. 2003;54:781–789
- . Caspase cleavage of the amyloid precursor protein modulates amyloid β-protein toxicity. J. Neurochem. 2003;87:733–741
- . DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. J. Neurosci. 2003;23(17):6914–6927
- . Abeta1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases. J. Cell Sci. 2007;120:279–288
- . Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go. Nature. 1993;362:75–79
- . Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions. Neurosci. Lett. 1992;136(1):75–78
- . In vitro aging of beta amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 1991;563:311–314
- . A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J. Neurochem. 2000;74:2331–2342
- . APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat. Genet. 2006;38(1):24–26
- . Fe65 and the protein network centered around the cytosolic domain of the Alzheimeŕs beta-amyloid precursor protein. FEBS Lett. 1998;434:1–7
- . The role of G protein activation in the toxicity of amyloidogenic Abeta-(1–40), Abeta-(25–35), and bovine calcitonin. J. Biol. Chem. 2001;276(4):2523–2530
- . Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J. Neurosci. 2006;26(52):13428–13436
- . Increased APP expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006;51(1):29–42
- . The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix.. Brain Res. 1993;629(2):275–282
- . Alzheimer's disease: genes, proteins and therapy. Physiol. Rev. 2001;81:741–766
- . Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597–624). FASEB J. 2006;20(8):1254–1256
- . Antibody-regulated neurotoxic function of cell-surface beta amyloid precursor protein. Mol. Cell. Neurosci. 2000;16:708–723
- . Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins. Neuron. 1992;8(4):799–809
- . Characterization of the toxic mechanism triggered by Alzheimer's Amyloid beta peptides via p75 neurotrophin receptor in neuronal hybrid cells. J. Neurosci. Res. 2003;73:627–636
- . Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein. J. Neurosci. 1999;19(16):6955–6964
- . Localization of a fibrillar amyloid beta-protein binding domain on its precursor. J. Biol. Chem. 2002;277(27):36392–36398
- . Beta-Amyloid(1–42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J. Biol. Chem. 2000;275(8):5626–5632
- . Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection. J. Biol. Chem. 2002;277(20):17649–17656
- . Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid-like protein 2 resulting in cellular accumulation.. Brain Res. 2003;966:231–244
- . Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J. Clin. Invest. 1997;100(9):2333–2340
- . G protein-mediated neuronal DNA fragmentation induced by familial Alzheimeŕs disease-associated mutants of APP. Science. 1996;272:1349–1352
- . RAGE and Abeta peptide neurotoxicity in Alzheimer's disease. Nature. 1996;382:685–691
- . The amyloid precursor protein: beyond amyloid. Mol. Neurodegener. 2006;1:5
PII: S0197-4580(07)00450-2
doi: 10.1016/j.neurobiolaging.2007.11.017
© 2007 Elsevier Inc. All rights reserved.
« Previous
Next »
Neurobiology of Aging
Volume 30, Issue 9
, Pages 1379-1392
, September 2009
