« Previous
Next »
Neurobiology of Aging
Volume 30, Issue 9
, Pages 1350-1360
, September 2009
APOE genotype-specific differences in the innate immune response
References
- . The cell biology of macrophage activation. Annu. Rev. Immunol. 1984;2:283–318
- . Apolipoprotein E suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells. J. Biol. Chem. 1982;257:5900–5909
- . Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature. 1997;388:878–881
- . Apolipoprotein E isoform mediated regulation of nitric oxide release. Free Radic. Biol. Med. 2002;32:1071–1075
- . Androgen-mediated immune function is altered by the apolipoprotein E gene. Endocrinology. 2007;148:3390
- Brown, C., Choi, E., Xu, Q., Vitek, M., Colton, C.A., 2007. The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol. Neurobiol. Aging, June 4 (Epub ahead of print)
- . APOE genotype is a major predictor of long term progression of disability in MS. Neurology. 2001;56:312–316
- . Apolipoprotein-E allele specific regulation of nitric oxide production. N.Y. Acad. Sci. 2002;962:212–225
- . APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. Neurobiol. Aging. 2002;23:777–785
- . Sex steroids APOE genotype and the innate immune system. Neurobiol. Aging. 2005;26:363–372
- . A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J. Clin. Psychiatry. 2007;68:613–618
- . HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy. Nat. Med. 1998;4:1182–1184
- . Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport. J. Neuroimmunol. 2002;4673:1–8
- . Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection. J. Lipid Res. 1999;40:680–685
- . Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Curr. Alzheimer Res. 2007;4:185–189
- . 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J. Biol. Chem. 1997;272:4959–4963
- . Alternative activation of macrophages. Nat. Rev. Immunol. 2003;3:23–35
- . Apolipoprotein E genotype differentially influences the pro-inflammatory and anti-inflammatory response to cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 2001;122:622–623
- . A dual role for apolipoprotein E in neuroinflammation: anti- and pro-inflammatory activity. J. Mol. Neurosci. 2004;23:205–212
- . Immunoregulatory plasma lipoproteins role of apoprotein E and apoprotein B. J. Biol. Chem. 1980;255:11775–11781
- . Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression. Biochem. Biophys. Res. Commun. 2007;357:319–324
- . Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. J. Am. Med. Soc. 1997;278:2143–2145
- . CAT2-mediated l-arginine transport and nitric oxide production in activated macrophages. Biochem. J. 1999;340:549–553
- . Lower cognitive performance of older football players possessing apolipoprotein E epsilon4. Neurosurgery. 2000;47:651–657
- . Altered immune responses in apolipoprotein E-deficient mice. J. Lipid Res. 2000;41:613–620
- . Down regulation of microglial activation by apolipoprotein E and apoE mimetic peptides. Exp. Neurol. 2001;167:74–85
- . COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J. Neurotrauma. 2007;24:1093–1107
- . Activation of innate immunity in the CNS triggers neurodegeneration through a Toll like receptor 4 dependent pathway. Proc. Natl. Acad. Sci. 2003;10:8514–8519
- . In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. Brain Res. 1986;384:145–155
- . Genetic risk profiles for Alzheimer's disease: integration of APOE genotype and variants that up-regulate inflammation. Neurobiol. Aging. 2007;28:1637–1643
- . Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 2001;25:402–408
- . Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J. Neuroimmunol. 2001;114:107–113
- . Suppression of lymphocyte activation by plasma lipoproteins. Cancer Res. 1983;43(Suppl. 5):2496s–2502s
- . Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. J. Neuroinflamm. 2006;3:10
- . Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK. FASEB J. 2006;20:797–799
- . Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2006;103:5641–5643
- . Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E. Mol. Pathol. 2003;56:132–136
- . Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade. Neurobiol. Dis. 2005;20(3):709–718
- . Resident macrophages of the central nervous system: Modulation of phenotype in relation to a specialized microenvironment. In: Goetzl E editors. Neuroimmune Networks: Physiology and Diseases. New York, NY: Alan R. Liss, Inc.; 1989;p. 119–125
- . Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain. Brain Res. Mol. Brain Res. 2001;86:76–83
- . Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo. J. Lipid Res. 1998;39:1740–1743
- . Apolipoprotein E, a gene with complex biological interactions in the aging brain. Neurobiol. Dis. 1997;4:170–185
- . The Brain's immune system. Sci. Am. 1995;273:38
- . Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe2. J. Clin. Invest. 1998;102:130–135
- . Modulation of nitric oxide production in human macrophages by apolipoprotein E and amyloid beta peptide. Biophys. Biochem. Res. Commun. 1997;240:391–394
- . Human apolipoprotein E2, E3 and E4 isoform-specific transgenic mice: human like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild type mice. Neurobiol. Dis. 1996;3:229–245
PII: S0197-4580(07)00445-9
doi: 10.1016/j.neurobiolaging.2007.11.014
© 2007 Elsevier Inc. All rights reserved.
« Previous
Next »
Neurobiology of Aging
Volume 30, Issue 9
, Pages 1350-1360
, September 2009
