Neurobiology of Aging
Volume 30, Issue 7 , Pages 1048-1051 , July 2009

SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese

  • E.K. Tan

      Affiliations

    • Department of Neurology, Singapore General Hospital, Singapore
    • National Neuroscience Institute, Singapore
    • Corresponding Author InformationCorresponding author at: Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. Tel.: +65 6326 5003; fax: +65 6220 3321.
    • ,
  • J. Lee

      Affiliations

    • Department of Neurology, Singapore General Hospital, Singapore
    • ,
  • C.P. Chen

      Affiliations

    • National University of Singapore, Singapore
    • ,
  • Y.Y. Teo

      Affiliations

    • University of Oxford, United Kingdom
    • ,
  • Y. Zhao

      Affiliations

    • Department of Clinical Research, Singapore General Hospital, Singapore
    • ,
  • W.L. Lee

      Affiliations

    • National Neuroscience Institute, Singapore

Received 8 August 2007 ,Revised 18 October 2007 ,Accepted 25 October 2007.

References 

  1. Andersen OM, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, et al. Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry. 2006;45(8):2618–2628
  2. Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 2005;102(38):13461–13466
  3. Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH, et al. A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J. Clin. Psychiatry. 2007;68(4):613–618
  4. De Ferrari GV, Papassotiropoulos A, Biechele T, Wavrant De-Vrieze F, Avila ME, Major MB, et al. Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2007;104(22):9434–9439
  5. Grupe A, Abraham R, Li Y, Rowland C, Hollingworth P, Morgan A, et al. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Hum. Mol. Genet. 2007;16(8):865–873
  6. Kamboh MI. Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease. Hum. Biol. 1995;67(2):195–215
  7. Lee JH, Cheng R, Schupf N, Manly J, Lantigua R, Stern Y, et al. The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort. Arch. Neurol. 2007;64(4):501–506
  8. Liu F, Arias-Vasquez A, Sleegers K, Aulchenko YS, Kayser M, Sanchez-Juan P, et al. A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. Am. J. Hum. Genet. 2007;81(1):17–31
  9. Nussbaum RL, Ellis CE. Alzheimer's disease and Parkinson's disease. N. Engl. J. Med. 2002;347:1867–1875
  10. Reiman EM. Linking brain imaging and genomics in the study of Alzheimer's disease and aging. Ann. N.Y. Acad. Sci. 2007;1097:94–113
  11. Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat. Genet. 2007;39(2):168–177
  12. Zhao Y, Cui JG, Lukiw WJ. Reduction of sortilin-1 in Alzheimer hippocampus and in cytokine-stressed human brain cells. Neuroreport. 2007 Jul 16;18(11):1187–1191

PII: S0197-4580(07)00415-0

doi: 10.1016/j.neurobiolaging.2007.10.013

Neurobiology of Aging
Volume 30, Issue 7 , Pages 1048-1051 , July 2009

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