Neurobiology of Aging
Volume 30, Issue 6 , Pages 898-902, June 2009

Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals

  • Janka Koschack

      Affiliations

    • Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Straße 5, D-37075 Göttingen, FRG, Germany
    • Department of General Practice, University of Göttingen, Germany
    • ,
  • Dieter Lütjohann

      Affiliations

    • Department of Clinical Pharmacology, University of Bonn, Germany
    • ,
  • Carsten Schmidt-Samoa

      Affiliations

    • Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Straße 5, D-37075 Göttingen, FRG, Germany
    • ,
  • Eva Irle

      Affiliations

    • Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Straße 5, D-37075 Göttingen, FRG, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +551 398950; fax: +551 3912712.

Received 16 August 2007; received in revised form 5 October 2007; accepted 18 October 2007. published online 03 December 2007.

Abstract 

The present study assessed the association between serum 24S-hydroxycholesterol (24S-OH-Chol) and 27-hydroxycholesterol (27-OH-Chol) and hippocampal volumes in 69 middle-aged cognitively normal individuals. Results showed that subjects with high levels of oxysterols had significantly larger hippocampal volumes than subjects with low levels of oxysterols. Multiple regression analysis revealed that 24S-OH-Chol, but not 27-OH-Chol or cholesterol, was able to significantly predict hippocampal size. Future studies should elucidate whether high brain cholesterol metabolism in the middle age is protective against hippocampal atrophy and cognitive decline.

Keywords: 24S-hydroxycholesterol, Cholesterol, Hippocampus, Aging

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0197-4580(07)00411-3

doi:10.1016/j.neurobiolaging.2007.10.010

Neurobiology of Aging
Volume 30, Issue 6 , Pages 898-902, June 2009

Article Tools

* Image Usage & Resolution