Neurobiology of Aging
Volume 30, Issue 6 , Pages 903-909 , June 2009

Comparison of lifelong and late life exercise on oxidative stress in the cerebellum

  • Li Cui

      Affiliations

    • Department of Neuroscience, Evelyn F. & William L. McKnight Brain Institute, University of Florida College of Medicine, PO Box 100244, Gainesville, FL 32610-0244, USA
    • ,
  • Tim Hofer

      Affiliations

    • Department of Aging and Geriatrics, Institute on Aging, University of Florida, Gainesville, FL 32610, USA
    • ,
  • Asha Rani

      Affiliations

    • Department of Neuroscience, Evelyn F. & William L. McKnight Brain Institute, University of Florida College of Medicine, PO Box 100244, Gainesville, FL 32610-0244, USA
    • ,
  • Christiaan Leeuwenburgh

      Affiliations

    • Department of Aging and Geriatrics, Institute on Aging, University of Florida, Gainesville, FL 32610, USA
    • ,
  • Thomas C. Foster

      Affiliations

    • Department of Neuroscience, Evelyn F. & William L. McKnight Brain Institute, University of Florida College of Medicine, PO Box 100244, Gainesville, FL 32610-0244, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 352 392 4359; fax: +1 352 392 8347.

Received 30 April 2007 ,Revised 25 July 2007 ,Accepted 12 September 2007.

References 

  1. Andersen BB, Gundersen HJ, Pakkenberg B. Aging of the human cerebellum: a stereological study. J. Comp. Neurol. 2003;466(3):356–365
  2. Barja G. Free radicals and aging. Trends Neurosci. 2004;27(10):595–600
  3. Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, Foster TC, et al. Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J. Neurosci. 2003;23(9):3807–3819
  4. Cardozo-Pelaez F, Song S, Parthasarathy A, Hazzi C, Naidu K, Sanchez-Ramos J. Oxidative DNA damage in the aging mouse brain. Mov. Disord. 1999;14(6):972–980
  5. Carter CS, Cesari M, Ambrosius WT, Hu N, Diz D, Oden S, et al. Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats. J. Gerontol. A Biol. Sci. Med. Sci. 2004;59(5):416–423
  6. Churchill JD, Galvez R, Colcombe S, Swain RA, Kramer AF, Greenough WT. Exercise experience and the aging brain. Neurobiol. Aging. 2002;23(5):941–955
  7. Devi SA, Kiran TR. Regional responses in antioxidant system to exercise training and dietary vitamin E in aging rat brain. Neurobiol. Aging. 2004;25(4):501–508
  8. Dorszewska J, Adamczewska-Goncerzewicz Z. Oxidative damage to DNA, p53 gene expression and p53 protein level in the process of aging in rat brain. Respir. Physiol. Neurobiol. 2004;139(3):227–236
  9. Forster MJ, Dubey A, Dawson KM, Stutts WA, Lal H, Sohal RS. Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc. Natl. Acad. Sci. U.S.A. 1996;93(10):4765–4769
  10. Foster TC. Biological markers of age-related memory deficits: treatment of senescent physiology. CNS Drugs. 2006;20(2):153–166
  11. Gedik CM, Grant G, Morrice PC, Wood SG, Collins AR. Effects of age and dietary restriction on oxidative DNA damage, antioxidant protection and DNA repair in rats. Eur. J. Nutr. 2005;44(5):263–272
  12. Grady RM, Wozniak DF, Ohlemiller KK, Sanes JR. Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin. J. Neurosci. 2006;26(11):2841–2851
  13. Grimaldi P, Rossi F. Lack of neurogenesis in the adult rat cerebellum after Purkinje cell degeneration and growth factor infusion. Eur. J. Neurosci. 2006;23(10):2657–2668
  14. Hamilton ML, Van Remmen H, Drake JA, Yang H, Guo ZM, Kewitt K, et al. Does oxidative damage to DNA increase with age?. Proc. Natl. Acad. Sci. U.S.A. 2001;98(18):10469–10474
  15. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956;11(3):298–300
  16. Hofer T, Seo AY, Prudencio M, Leeuwenburgh C. A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration. Biol. Chem. 2006;387(1):103–111
  17. Holloszy JO, Schechtman KB. Interaction between exercise and food restriction: effects on longevity of male rats. J. Appl. Physiol. 1991;70(4):1529–1535
  18. Holloszy JO, Smith EK, Vining M, Adams S. Effect of voluntary exercise on longevity of rats. J. Appl. Physiol. 1985;59(3):826–831
  19. Hu D, Serrano F, Oury TD, Klann E. Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase. J. Neurosci. 2006;26(15):3933–3941
  20. Huang CM, Miyamoto H, Huang RH. The mouse cerebellum from 1 to 34 months: parallel fibers. Neurobiol. Aging. 2005;27(11):1715–1718
  21. Jolitha AB, Subramanyam MV, Asha Devi S. Modification by vitamin E and exercise of oxidative stress in regions of aging rat brain: studies on superoxide dismutase isoenzymes and protein oxidation status. Exp. Gerontol. 2006;41(8):753–763
  22. Judge S, Jang YM, Smith A, Selman C, Phillips T, Speakman JR, et al. Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005;289(6):R1564–R1572
  23. Klintsova AY, Dickson E, Yoshida R, Greenough WT. Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise. Brain Res. 2004;1028(1):92–104
  24. Kuhn HG, Winkler J, Kempermann G, Thal LJ, Gage FH. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J. Neurosci. 1997;17(15):5820–5829
  25. Larsen JO, Skalicky M, Viidik A. Does long-term physical exercise counteract age-related Purkinje cell loss? A stereological study of rat cerebellum. J. Comp. Neurol. 2000;428(2):213–222
  26. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch. Neurol. 2001;58(3):498–504
  27. Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, et al. Gene regulation and DNA damage in the ageing human brain. Nature. 2004;429(6994):883–891
  28. Marzetti E, Leeuwenburgh C. Skeletal muscle apoptosis, sarcopenia and frailty at old age. Exp. Gerontol. 2006;41(12):1234–1238
  29. Mattson MP, Wan R. Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. J. Nutr. Biochem. 2005;16(3):129–137
  30. Mecocci P, MacGarvey U, Kaufman AE, Koontz D, Shoffner JM, Wallace DC, et al. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann. Neurol. 1993;34(4):609–616
  31. Monteiro RA, Henrique RM, Rocha E, Marini-Abreu MM, Oliveira MH, Silva MW. Age-related changes in the volume of somata and organelles of cerebellar granule cells. Neurobiol. Aging. 1998;19(4):325–332
  32. Navarro A, Gomez C, Lopez-Cepero JM, Boveris A. Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004;286(3):R505–R511
  33. Ogonovszky H, Berkes I, Kumagai S, Kaneko T, Tahara S, Goto S, et al. The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain. Neurochem. Int. 2005;46(8):635–640
  34. Pedreanez A, Arcaya JL, Carrizo E, Mosquera J. Forced swimming test increases superoxide anion positive cells and angiotensin II positive cells in the cerebrum and cerebellum of the rat. Brain Res. Bull. 2006;71(1–3):18–22
  35. Radak Z, Kaneko T, Tahara S, Nakamoto H, Pucsok J, Sasvari M, et al. Regular exercise improves cognitive function and decreases oxidative damage in rat brain. Neurochem. Int. 2001;38(1):17–23
  36. Richards M, Hardy R, Wadsworth ME. Does active leisure protect cognition? Evidence from a national birth cohort. Soc. Sci. Med. 2003;56(4):785–792
  37. Rogers DC, Fisher EM, Brown SD, Peters J, Hunter AJ, Martin JE. Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm. Genome. 1997;8(10):711–713
  38. Rutten BP, Schmitz C, Gerlach OH, Oyen HM, de Mesquita EB, Steinbusch HW, et al. The aging brain: accumulation of DNA damage or neuron loss?. Neurobiol. Aging. 2007;28(1):91–98
  39. Semba RD, Blaum C, Guralnik JM, Moncrief DT, Ricks MO, Fried LP. Carotenoid and vitamin E status are associated with indicators of sarcopenia among older women living in the community. Aging Clin. Exp. Res. 2003;15(6):482–487
  40. Seo AY, Hofer T, Sung B, Judge S, Chung HY, Leeuwenburgh C. Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise. Antioxid. Redox Signal. 2006;8(3–4):529–538
  41. Sohal RS, Agarwal S, Candas M, Forster MJ, Lal H. Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech. Ageing Dev. 1994;76(2–3):215–224
  42. Tsakiris T, Angelogianni P, Tesseromatis C, Tsakiris S, Tsopanakis C. Alterations in antioxidant status, protein concentration, acetylcholinesterase, Na+, K+-ATPase, and Mg2+-ATPase activities in rat brain after forced swimming. Int. J. Sports Med. 2006;27(1):19–24
  43. van Praag H, Shubert T, Zhao C, Gage FH. Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 2005;25(38):8680–8685
  44. Washburn RA, Smith KW, Jette AM, Janney CA. The Physical Activity Scale for the Elderly (PASE): development and evaluation. J. Clin. Epidemiol. 1993;46(2):153–162
  45. Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K. A prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch. Intern. Med. 2001;161(14):1703–1708

PII: S0197-4580(07)00377-6

doi: 10.1016/j.neurobiolaging.2007.09.005

Neurobiology of Aging
Volume 30, Issue 6 , Pages 903-909 , June 2009

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