Comparison of lifelong and late life exercise on oxidative stress in the cerebellum

Cui, Li; Hofer, Tim; Rani, Asha; Leeuwenburgh, Christiaan; Foster, Thomas C.

doi:10.1016/j.neurobiolaging.2007.09.005

« Previous Next »Neurobiology of Aging
Volume 30, Issue 6 , Pages 903-909, June 2009

Comparison of lifelong and late life exercise on oxidative stress in the cerebellum

Li Cui
- Department of Neuroscience, Evelyn F. & William L. McKnight Brain Institute, University of Florida College of Medicine, PO Box 100244, Gainesville, FL 32610-0244, USA
Tim Hofer
- Department of Aging and Geriatrics, Institute on Aging, University of Florida, Gainesville, FL 32610, USA
Asha Rani
- Department of Neuroscience, Evelyn F. & William L. McKnight Brain Institute, University of Florida College of Medicine, PO Box 100244, Gainesville, FL 32610-0244, USA
Christiaan Leeuwenburgh
- Department of Aging and Geriatrics, Institute on Aging, University of Florida, Gainesville, FL 32610, USA
Thomas C. Foster
- Department of Neuroscience, Evelyn F. & William L. McKnight Brain Institute, University of Florida College of Medicine, PO Box 100244, Gainesville, FL 32610-0244, USA
- Corresponding author. Tel.: +1 352 392 4359; fax: +1 352 392 8347.

Received 30 April 2007; received in revised form 25 July 2007; accepted 12 September 2007. published online 02 November 2007.

Abstract

Aging was associated with increased oxidation of DNA, RNA, and lipids in the cerebellum of male rats. DNA and lipid oxidation was reduced by lifelong (94 weeks) voluntary exercise on a running wheel. A reduction in cerebellar lipid oxidation, but not RNA or DNA oxidation, was observed following 3 months of moderate exercise or dietary supplementation of vitamin E, initiated at 18 months of age. The level of lipid oxidation correlated with measures of forelimb grip strength. The results indicate that lifelong exercise attenuates multiple molecular markers of age-related oxidative damage in the cerebellum. In addition, modest exercise initiated late in life can have a beneficial effect on lipid oxidation and motor function.

Keywords: Aging, Cerebellum, Voluntary exercise, Nucleic acid oxidation, Lipid peroxidation, Rat