Neurobiology of Aging
Volume 30, Issue 5 , Pages 759-768 , May 2009

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

  • Maryse Letiembre

      Affiliations

    • University of the Saarland, Department of Neurology, Kirrberger Strasse, 66421 Homburg/Saar, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 6841 16 47 913; fax: +49 6841 16 47 801.
    • ,
  • Yang Liu

      Affiliations

    • University of the Saarland, Department of Neurology, Kirrberger Strasse, 66421 Homburg/Saar, Germany
    • ,
  • Silke Walter

      Affiliations

    • University of the Saarland, Department of Neurology, Kirrberger Strasse, 66421 Homburg/Saar, Germany
    • ,
  • Wenlin Hao

      Affiliations

    • University of the Saarland, Department of Neurology, Kirrberger Strasse, 66421 Homburg/Saar, Germany
    • ,
  • Tatjana Pfander

      Affiliations

    • University of Göttingen, Department of Neuropathology, Robert-Koch Strasse 40, 37075 Göttingen, Germany
    • ,
  • Arne Wrede

      Affiliations

    • University of Göttingen, Department of Neuropathology, Robert-Koch Strasse 40, 37075 Göttingen, Germany
    • ,
  • Walter Schulz-Schaeffer

      Affiliations

    • University of Göttingen, Department of Neuropathology, Robert-Koch Strasse 40, 37075 Göttingen, Germany
    • These authors contributed equally to this work.
    • ,
  • Klaus Fassbender

      Affiliations

    • University of the Saarland, Department of Neurology, Kirrberger Strasse, 66421 Homburg/Saar, Germany
    • These authors contributed equally to this work.
    • Corresponding Author InformationCorresponding author. Tel.: +49 6841 16 24 103; fax: +49 6841 16 24 137.

Received 10 June 2007 ,Revised 10 August 2007 ,Accepted 14 August 2007.

References 

  1. Abreu MT, Arditi M. Innate immunity and toll-like receptors: clinical implications of basic science research. J. Pediatr. 2004;144(4):421–429
  2. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, et al. Inflammation and Alzheimer's disease. Neurobiol. Aging. 2000;21(3):383–421
  3. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, et al. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat. Med. 2000;6(4):435–442
  4. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, et al. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J. Biol. Chem. 2002;277(17):15028–15034
  5. Beyreuther K, Bush AI, Dyrks T, Hilbich C, Konig G, Monning U, et al Mechanisms of amyloid deposition in Alzheimer's disease. Ann. N.Y. Acad. Sci. 1991;640:129–139
  6. Bsibsi M, Ravid R, Gveric D, van Noort JM. Broad expression of Toll-like receptors in the human central nervous system. J. Neuropathol. Exp. Neurol. 2002;61(11):1013–1021
  7. Chen K, Iribarren P, Hu J, Chen J, Gong W, Cho EH, et al. Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide. J. Biol. Chem. 2006;281(6):3651–3659
  8. Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, et al. Early onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J. Biol. Chem. 2001;276(24):21562–21570
  9. Cluskey S, Ramsden DB. Mechanisms of neurodegeneration in amyotrophic lateral sclerosis. Mol. Pathol. 2001;54(6):386–392
  10. Dal Canto MC, Gurney ME. Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis. Am. J. Pathol. 1994;145(6):1271–1279
  11. DiCarlo G, Wilcock D, Henderson D, Gordon M, Morgan D. Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice. Neurobiol. Aging. 2001;22(6):1007–1012
  12. Dudal S, Krzywkowski P, Paquette J, Morissette C, Lacombe D, Tremblay P, et al. Inflammation occurs early during the Abeta deposition process in TgCRND8 mice. Neurobiol. Aging. 2004;25(7):861–871
  13. Dybdahl B, Wahba A, Lien E, Flo TH, Waage A, Qureshi N, et al. Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation. 2002;105(6):685–690
  14. Eriksen JL, Wszolek Z, Petrucelli L. Molecular pathogenesis of Parkinson disease. Arch. Neurol. 2005;62(3):353–357
  15. Fassbender K, Walter S, Kuhl S, Landmann R, Ishii K, Bertsch T, et al. The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB J. 2004;18(1):203–205
  16. Franklin TB, Krueger-Naug AM, Clarke DB, Arrigo AP, Currie RW. The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system. Int. J. Hyperthermia. 2005;21(5):379–392
  17. Frasier M, Walzer M, McCarthy L, Magnuson D, Lee JM, Haas C, et al. Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein. Exp. Neurol. 2005;192(2):274–287
  18. Gurney ME. Transgenic-mouse model of amyotrophic lateral sclerosis. N. Engl. J. Med. 1994;331(25):1721–1722
  19. Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD, et al Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science. 1994;264(5166):1772–1775
  20. Herber DL, Roth LM, Wilson D, Wilson N, Mason JE, Morgan D, et al. Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice. Exp. Neurol. 2004;190(1):245–253
  21. Iribarren P, Chen K, Hu J, Gong W, Cho EH, Lockett S, et al. CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein-coupled receptor mFPR2. FASEB J. 2005;19(14):2032–2034
  22. Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Schindzielorz A, et al. Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha-synuclein in human and transgenic mouse brain. J. Neurosci. 2000;20(17):6365–6373
  23. Kahle PJ, Neumann M, Ozmen L, Muller V, Odoy S, Okamoto N, et al. Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am. J. Pathol. 2001;159(6):2215–2225
  24. Kakimura J, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, et al. Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. FASEB J. 2002;16(6):601–603
  25. Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J. Neurosci. 2005;25(39):8843–8853
  26. Kramer ML, Schulz-Schaeffer WJ. Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J. Neurosci. 2007;27(6):1405–1410
  27. Lee J, Chan SL, Mattson MP. Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. Neuromol. Med. 2002;2(1):29–45
  28. Letiembre M, Hao W, Liu Y, Walter S, Mihaljevic I, Rivest S, et al. Innate immune receptor expression in normal brain aging. Neuroscience. 2007;146(1):248–254
  29. Liu Y, Walter S, Stagi M, Cherny D, Letiembre M, Schulz-Schaeffer W, et al. LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide. Brain. 2005;128(Pt 8):1778–1789
  30. Moore DJ, West AB, Dawson VL, Dawson TM. Molecular pathophysiology of Parkinson's disease. Annu. Rev. Neurosci. 2005;28:57–87
  31. Nguyen MD, D’Aigle T, Gowing G, Julien JP, Rivest S. Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J. Neurosci. 2004;24(6):1340–1349
  32. Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc. Natl. Acad. Sci. U.S.A. 2000;97(25):13766–13771
  33. Qureshi ST, Medzhitov R. Toll-like receptors and their role in experimental models of microbial infection. Genes Immun. 2003;4(2):87–94
  34. Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron. 1991;6(4):487–498
  35. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001;81(2):741–766
  36. Tahara K, Kim HD, Jin JJ, Maxwell JA, Li L, Fukuchi KI. Role of toll-like receptor signalling in A{beta} uptake and clearance. Brain. 2006;129(Pt 11):3006–3019
  37. Takeda K, Takeuchi O, Akira S. Recognition of lipopeptides by toll-like receptors. J. Endotoxin Res. 2002;8(6):459–463
  38. Teismann P, Schulz JB. Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res. 2004;318(1):149–161
  39. Town T, Nikolic V, Tan J. The microglial “activation” continuum: from innate to adaptive responses. J. Neuroinflammation. 2005;2:24
  40. Tsan MF, Baochong G. Pathogen-associated molecular pattern contamination as putative endogenous ligands of toll-like receptors. J. Endotoxin Res. 2007;13(1):6–14
  41. Underhill DM. Toll-like receptors: networking for success. Eur. J. Immunol. 2003;33(7):1767–1775
  42. Vabulas RM, Ahmad-Nejad P, Ghose S, Kirschning CJ, Issels RD, Wagner H. HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J. Biol. Chem. 2002;277(17):15107–15112
  43. Vabulas RM, Braedel S, Hilf N, Singh-Jasuja H, Herter S, Ahmad-Nejad P, et al. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J. Biol. Chem. 2002;277(23):20847–20853
  44. Vabulas RM, Wagner H, Schild H. Heat shock proteins as ligands of toll-like receptors. Curr. Top. Microbiol. Immunol. 2002;270:169–184
  45. Walter S, Doering A, Letiembre M, Liu Y, Hao W, Diem R, et al. The LPS receptor, CD14 in experimental autoimmune encephalomyelitis and multiple sclerosis. Cell Physiol. Biochem. 2006;17(3–4):167–172

PII: S0197-4580(07)00344-2

doi: 10.1016/j.neurobiolaging.2007.08.018

Neurobiology of Aging
Volume 30, Issue 5 , Pages 759-768 , May 2009

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