Neurobiology of Aging
Volume 30, Issue 4 , Pages 574-590 , April 2009

Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E

  • Simon P. Selwood

      Affiliations

    • Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA, United States
    • Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States
    • These authors contributed equally to this work.
    • ,
  • S. Parvathy

      Affiliations

    • Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA, United States
    • Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States
    • These authors contributed equally to this work.
    • ,
  • Barbara Cordell

      Affiliations

    • Formerly of Scios, Inc., Fremont, CA, United States
    • ,
  • Heather S. Ryan

      Affiliations

    • Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA, United States
    • Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States
    • Department of Veterans Affairs Sierra Pacific MIRECC, Palo Alto VA Health Care System, Palo Alto, CA, United States
    • ,
  • Farshid Oshidari

      Affiliations

    • Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA, United States
    • Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States
    • ,
  • Valerie Vincent

      Affiliations

    • Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA, United States
    • Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States
    • ,
  • Jerome Yesavage

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States
    • Department of Veterans Affairs Sierra Pacific MIRECC, Palo Alto VA Health Care System, Palo Alto, CA, United States
    • ,
  • Laura C. Lazzeroni

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States
    • ,
  • Greer M. Murphy Jr.

      Affiliations

    • Neuroscience Research Laboratories, Stanford University School of Medicine, Stanford, CA, United States
    • Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States
    • Department of Veterans Affairs Sierra Pacific MIRECC, Palo Alto VA Health Care System, Palo Alto, CA, United States
    • Corresponding Author InformationCorresponding author at: Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Medical School Lab Surge Building, Rm. P-104, Stanford, CA 94305-5485, United States. Tel.: +1 650 725 0565; fax: +1 650 498 7761.

Received 7 January 2007 ,Revised 7 August 2007 ,Accepted 8 August 2007.

References 

  1. Agostinho P, Oliveira CR. Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides. Eur. J. Neurosci. 2003;17(6):1189–1196
  2. Bales KR, Verina T, Cummins DJ, Du Y, Dodel RC, Saura J, et al. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 1999;96(26):15233–15238
  3. Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition [letter] [see comments]. Nat. Genet. 1997;17(3):263–264
  4. Bamberger ME, Harris ME, McDonald DR, Husemann J, Landreth GE. A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J. Neurosci. 2003;23(7):2665–2674
  5. Barger SW, Van Eldik LJ. S100 beta stimulates calcium fluxes in glial and neuronal cells. J. Biol. Chem. 1992;267(14):9689–9694
  6. Barrientos A, Casademont J, Cardellach F, Estivill X, Urbano-Marquez A, Nunes V. Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging. Brain Res. Mol. Brain Res. 1997;52(2):284–289
  7. Bernstein HG, Bukowska A, Krell D, Bogerts B, Ansorge S, Lendeckel U. Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome. J. Neurocytol. 2003;32(2):153–160
  8. Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW. Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc. Natl. Acad. Sci. U.S.A. 2004;101(7):2173–2178
  9. Brooks WM, Lynch PJ, Ingle CC, Hatton A, Emson PC, Faull RL, et al. Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease. Brain Res. 2007;1127(1):127–135
  10. Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, et al. Expression of human apolipoprotein E3 or E4 in the brains of Apoe−/− mice: isoform-specific effects on neurodegeneration. J. Neurosci. 1999;19(12):4867–4880
  11. Castegna A, Thongboonkerd V, Klein J, Lynn BC, Wang YL, Osaka H, et al. Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins. J. Neurochem. 2004;88(6):1540–1546
  12. Chen TY, Liu PH, Ruan CT, Chiu L, Kung FL. The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein. Biochem. Biophys. Res. Commun. 2006;342(1):266–272
  13. Christelle, A., 2004. Proteomic analysis of inflammatory protein expression patterns in cell culture and transgenic animal models of Alzheimer's disease [Ph.D.]. University of Basel, Basel, 99 pp.
  14. Chu S, Zengel JM, Lindahl L. A novel protein shared by RNase MRP and RNase P. RNA. 1997;3(4):382–391
  15. Chung IH, Lee SH, Lee KW, Park SH, Cha KY, Kim NS, et al. Gene expression analysis of cultured amniotic fluid cell with Down syndrome by DNA microarray. J. Korean Med. Sci. 2005;20(1):82–87
  16. Colangelo V, Schurr J, Ball MJ, Pelaez RP, Bazan NG, Lukiw WJ. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J. Neurosci. Res. 2002;70(3):462–473
  17. Colon AL, Menchen LA, Hurtado O, De Cristobal J, Lizasoain I, Leza JC, et al. Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis. Cytokine. 2001;16(6):220–226
  18. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261(5123):921–923
  19. DeMattos RB, Cirrito JR, Parsadanian M, May PC, O’Dell MA, Taylor JW, et al. ApoE and clusterin cooperatively suppress Abeta levels and deposition. Evidence that ApoE regulates extracellular abeta metabolism in vivo. Neuron. 2004;41(2):193–202
  20. Diez MM, Koistinaho JJ, Kahn KK, Games DD, Hökfelt TT. Neuropeptides in hippocampus and cortex in transgenic mice overexpressing V717F beta-amyloid precursor protein—initial observations. Neuroscience. 2000;100(2):259–286
  21. Ding Q, Markesbery WR, Chen Q, Li F, Keller JN. Ribosome dysfunction is an early event in Alzheimer's disease. J. Neurosci. 2005;25(40):9171–9175
  22. Dodart JC, Mathis C, Saura J, Bales KR, Paul SM, Ungerer A. Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice. Neurobiol. Dis. 2000;7(2):71–85
  23. Engidawork E, Baiic N, Fountoulakis M, Dierssen M, Greber-Platzer S, Lubec G. Beta-amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect. J. Neural. Transm. Suppl. 2001;(61):335–346
  24. Frenkel D, Maron R, Burt DS, Weiner HL. Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. J. Clin. Invest. 2005;115(9):2423–2433
  25. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, et al Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein [see comments]. Nature. 1995;373(6514):523–527
  26. Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, et al. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol. Cell. 1999;4(6):893–902
  27. Gong CX, Wang JZ, Iqbal K, Grundke-Iqbal I. Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices. Neurosci. Lett. 2003;340(2):107–110
  28. Hann BC, Walter P. The signal recognition particle in S. cerevisiae. Cell. 1991;67(1):131–144
  29. Hattori C, Asai M, Onishi H, Sasagawa N, Hashimoto Y, Saido TC, et al. BACE1 interacts with lipid raft proteins. J. Neurosci. Res. 2006;84(4):912–917
  30. Helisalmi S, Hiltunen M, Vepsalainen S, Iivonen S, Corder EH, Lehtovirta M, et al. Genetic variation in apolipoprotein D and Alzheimer's disease. J. Neurol. 2004;251(8):951–957
  31. Herren B. ADAM-mediated shedding and adhesion: a vascular perspective. News Physiol. Sci. 2002;17:73–76
  32. Hook VY, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, et al. The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. J. Biol. Chem. 1999;274(5):3165–3172
  33. Horiuchi K, Weskamp G, Lum L, Hammes HP, Cai H, Brodie TA, et al. Potential role for ADAM15 in pathological neovascularization in mice. Mol. Cell. Biol. 2003;23(16):5614–5624
  34. Horvath AJ, Irving JA, Rossjohn J, Law RH, Bottomley SP, Quinsey NS, et al. The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. J. Biol. Chem. 2005;280(52):43168–43178
  35. Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, et al. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron. 2004;44(2):227–238
  36. Ignatius MJ, Gebicke-Harter PJ, Skene JH, Schilling JW, Weisgraber KH, Mahley RW, et al. Expression of apolipoprotein E during nerve degeneration and regeneration. Proc. Natl. Acad. Sci. U.S.A. 1986;83(4):1125–1129
  37. Imaizumi K, Miyoshi K, Katayama T, Yoneda T, Taniguchi M, Kudo T, et al. The unfolded protein response and Alzheimer's disease. Biochim. Biophys. Acta. 2001;1536(2–3):85–96
  38. Iqbal K, Grundke-Iqbal I. Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies. Acta Neuropathol. (Berl.). 2005;109(1):25–31
  39. Johnson-Wood K, Lee M, Motter R, Hu K, Gordon G, Barbour R, et al. Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 1997;94(4):1550–1555
  40. Kaneda Y, Kinoshita K, Sato M, Saeki Y, Yamada R, Wataya-Kaneda M, et al. The induction of apoptosis in HeLa cells by the loss of LBP-p40. Cell Death Differ. 1998;5(1):20–28
  41. Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M. Induction of neuronal death by ER stress in Alzheimer's disease. J. Chem. Neuroanat. 2004;28(1–2):67–78
  42. Kazmin DA, Chinenov Y, Larson E, Starkey JR. Comparative modeling of the N-terminal domain of the 67kDa laminin-binding protein: implications for putative ribosomal function. Biochem. Biophys. Res. Commun. 2003;300(1):161–166
  43. Kelly AE, Kranitz H, Dotsch V, Mullins RD. Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex. J. Biol. Chem. 2006;281(15):10589–10597
  44. Kiuchi Y, Isobe Y, Fukushima K. Type IV collagen prevents amyloid beta-protein fibril formation. Life Sci. 2002;70(13):1555–1564
  45. Koenigsknecht J, Landreth G. Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism. J. Neurosci. 2004;24(44):9838–9846
  46. Krapfenbauer K, Engidawork E, Cairns N, Fountoulakis M, Lubec G. Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders. Brain Res. 2003;967(1–2):152–160
  47. Lee HC, Wei YH. Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int. J. Biochem. Cell Biol. 2005;37(4):822–834
  48. Lehmann DJ, Refsum H, Nurk E, Warden DR, Tell GS, Vollset SE, et al. Apolipoprotein E epsilon4 and impaired episodic memory in community-dwelling elderly people: a marked sex difference. The Hordaland Health Study. J. Neurol. Neurosurg. Psychiatry. 2006;77(8):902–908
  49. Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, et al. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Am. J. Pathol. 1995;146(4):848–860
  50. Li C, Hung Wong W. Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biol. 2001;2(8):(research 0032.1–.11)
  51. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. PNAS. 2001;98(1):31–36
  52. Liu L, Li Y, Van Eldik LJ, Griffin WS, Barger SW. S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors. J. Neurochem. 2005;92(3):546–553
  53. Maloney MT, Minamide LS, Kinley AW, Boyle JA, Bamburg JR. Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease. J. Neurosci. 2005;25(49):11313–11321
  54. Mandon EC, Jiang Y, Gilmore R. Dual recognition of the ribosome and the signal recognition particle by the SRP receptor during protein targeting to the endoplasmic reticulum. J. Cell. Biol. 2003;162(4):575–585
  55. Masliah E, Sisk A, Mallory M, Games D. Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. J. Neuropathol. Exp. Neurol. 2001;60(4):357–368
  56. Mattson MP, Chan SL. Calcium orchestrates apoptosis. Nat. Cell Biol. 2003;5(12):1041–1043
  57. Mattson MP, Chan SL. Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium. 2003;34(4–5):385–397
  58. Mattson MP, Gary DS, Chan SL, Duan W. Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease. Biochem. Soc. Symp. 2001;(67):151–162
  59. McComb RD, Moul JM, Bigner DD. Distribution of type VI collagen in human gliomas: comparison with fibronectin and glioma-mesenchymal matrix glycoprotein. J. Neuropathol. Exp. Neurol. 1987;46(6):623–633
  60. McGeer PL, McGeer EG. Inflammation, autotoxicity and Alzheimer disease. Neurobiol. Aging. 2001;22(6):799–809
  61. Meloni, B.P., Tilbrook, P.A., Boulos, S., Arthur, P.G., Knuckey, N.W., 2006. Erythropoietin preconditioning in neuronal cultures: signaling, protection from in vitro ischemia, and proteomic analysis. J. Neurosci. Res.
  62. Mitrasinovic OM, Murphy GM. Accelerated phagocytosis of amyloid-beta by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor. J. Biol. Chem. 2002;277(33):29889–29896
  63. Murphy GM, Zhao F, Yang L, Cordell B. Expression of macrophage colony-stimulating factor receptor is increased in the AbetaPP(V717F) transgenic mouse model of Alzheimer's disease. Am. J. Pathol. 2000;157(3):895–904
  64. Nagy Z, Esiri MM, Jobst KA, Johnston C, Litchfield S, Sim E, et al. Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease. Neuroscience. 1995;69(3):757–761
  65. Nilsson LN, Bales KR, DiCarlo G, Gordon MN, Morgan D, Paul SM, et al. Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease. J. Neurosci. 2001;21(5):1444–1451
  66. Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, et al. Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. J. Neurosci. 2005;25(18):4649–4658
  67. Oh SH, Adler HJ, Raphael Y, Lomax MI. WDR1 colocalizes with ADF and actin in the normal and noise-damaged chick cochlea. J. Comp. Neurol. 2002;448(4):399–409
  68. Pack-Chung E, Meyers MB, Pettingell WP, Moir RD, Brownawell AM, Cheng I, et al. Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. J. Biol. Chem. 2000;275(19):14440–14445
  69. Perez E, Barrachina M, Rodriguez A, Torrejon-Escribano B, Boada M, Hernandez I, et al. Aquaporin expression in the cerebral cortex is increased at early stages of Alzheimer disease. Brain Res. 2007;1128(1):164–174
  70. Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature. 2003;423(6938):435–439
  71. Pirttila T, Soininen H, Mehta PD, Heinonen O, Lehtimaki T, Bogdanovic N, et al. Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains. Neurobiol. Aging. 1997;18(1):121–127
  72. Poliquin L, Bergeron D, Fortier JL, Paquette Y, Bergeron R, Rassart E. Determinants of thymotropism in Kaplan radiation leukemia virus and nucleotide sequence of its envelope region. J. Virol. 1992;66(8):5141–5146
  73. Polvikoski T, Sulkava R, Haltia M, Kainulainen K, Vuorio A, Verkkoniemi A, et al. Dementia, and cortical deposition of beta-Amyloid protein. N. Engl. J. Med. 1995;333(19):1242–1248
  74. Poon HF, Farr SA, Banks WA, Pierce WM, Klein JB, Morley JE, et al. Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein. Brain Res. Mol. Brain Res. 2005;138(1):8–16
  75. Reddy PH. Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease. J. Neurochem. 2006;96(1):1–13
  76. Reddy PH, McWeeney S, Park BS, Manczak M, Gutala RV, Partovi D, et al. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum. Mol. Genet. 2004;13(12):1225–1240
  77. Risser R, Horowitz JM, McCubrey J. Endogenous mouse leukemia viruses. Annu. Rev. Genet. 1983;17:85–121
  78. Rodriguez A, Perez-Gracia E, Espinosa JC, Pumarola M, Torres JM, Ferrer I. Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt–Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice. Acta Neuropathol. (Berl.). 2006;112(5):573–585
  79. Romisch K, Miller FW, Dobberstein B, High S. Human autoantibodies against the 54kDa protein of the signal recognition particle block function at multiple stages. Arthritis Res. Ther. 2006;8(2):R39
  80. Sajdel-Sulkowska EM, Marotta CA. Alzheimer's disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex. Science. 1984;225(4665):947–949
  81. Sarafian TA, Verity MA, Vinters HV, Shih CC, Shi L, Ji XD, et al. Differential expression of peroxiredoxin subtypes in human brain cell types. J. Neurosci. Res. 1999;56(2):206–212
  82. Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 1993;90(20):9649–9653
  83. Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, et al. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell. 2001;107(7):893–903
  84. Sheng JG, Mrak RE, Bales KR, Cordell B, Paul SM, Jones RA, et al. Overexpression of the neuritotrophic cytokine S100beta precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice. J. Neurochem. 2000;74(1):295–301
  85. Shin DH, Lee E, Chung YH, Mun GH, Park J, Lomax MI, et al. Subcellular localization of WD40 repeat 1 protein in PC12 rat pheochromocytoma cells. Neurosci. Lett. 2004;367(3):399–403
  86. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. U.S.A. 2003;100(16):9440–9445
  87. Takeichi M, Abe K. Synaptic contact dynamics controlled by cadherin and catenins. Trends Cell. Biol. 2005;15(4):216–221
  88. Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP. IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev. Cell. 2005;9(6):745–756
  89. Tanimukai H, Grundke-Iqbal I, Iqbal K. Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. Am. J. Pathol. 2005;166(6):1761–1771
  90. Trommer BL, Shah C, Yun SH, Gamkrelidze G, Pasternak ES, Ye GL, et al. ApoE isoform affects LTP in human targeted replacement mice. Neuroreport. 2004;15(17):2655–2658
  91. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U.S.A. 2001;98(9):5116–5121
  92. Urmoneit B, Prikulis I, Wihl G, D’Urso D, Frank R, Heeren J, et al. Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy. Lab. Invest. 1997;77(2):157–166
  93. Wang C, Wilson WA, Moore SD, Mace BE, Maeda N, Schmechel DE, et al. Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiol. Dis. 2005;18(2):390–398
  94. Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, et al. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science. 1999;284(5412):339–343
  95. Webster SD, Yang AJ, Margol L, Garzon-Rodriguez W, Glabe CG, Tenner AJ. Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp. Neurol. 2000;161(1):127–138
  96. Weeraratna AT, Kalehua A, Deleon I, Bertak D, Maher G, Wade MS, et al. Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues. Exp. Cell Res. 2007;313(3):450–461
  97. Wick MJ, Ann DK, Lee NM, Loh HH. Isolation of a cDNA encoding a novel zinc-finger protein from neuroblastoma×glioma NG108-15 cells. Gene. 1995;152(2):227–232
  98. Yang DS, Small DH, Seydel U, Smith JD, Hallmayer J, Gandy SE, et al. Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner. Neuroscience. 1999;90(4):1217–1226
  99. Yao PJ, Zhu M, Pyun EI, Brooks AI, Therianos S, Meyers VE, et al. Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease. Neurobiol. Dis. 2003;12(2):97–109
  100. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258(5081):468–471

☆ Supported by NIMH awards MH40041, MH57833, NIA award AG17824, the VA Sierra Pacific MIRECC, and by the Alzheimer's Association.

☆☆ All animal procedures had received IACUC approval.

PII: S0197-4580(07)00332-6

doi: 10.1016/j.neurobiolaging.2007.08.006

Neurobiology of Aging
Volume 30, Issue 4 , Pages 574-590 , April 2009

Article Tools