Neurobiology of Aging
Volume 30, Issue 4 , Pages 600-606 , April 2009

Thyroid function, the risk of dementia and neuropathologic changes: The Honolulu–Asia Aging Study

  • Frank Jan de Jong

      Affiliations

    • Department of Epidemiology & Biostatistics, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
    • ,
  • Kamal Masaki

      Affiliations

    • Pacific Health Research Institute, 846 S Hotel Street, Honolulu, HI 96813, USA
    • ,
  • Hepei Chen

      Affiliations

    • Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, 3C-309 Bethesda, MD 20892, USA
    • ,
  • Alan T. Remaley

      Affiliations

    • Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA
    • ,
  • Monique M.B. Breteler

      Affiliations

    • Department of Epidemiology & Biostatistics, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
    • ,
  • Helen Petrovitch

      Affiliations

    • Pacific Health Research Institute, 846 S Hotel Street, Honolulu, HI 96813, USA
    • ,
  • Lon R. White

      Affiliations

    • Pacific Health Research Institute, 846 S Hotel Street, Honolulu, HI 96813, USA
    • ,
  • Lenore J. Launer

      Affiliations

    • Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, 3C-309 Bethesda, MD 20892, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 301 496 117; fax: +1 301 496 4006.

Received 5 December 2006 ,Revised 26 June 2007 ,Accepted 28 July 2007.

References 

  1. American Psychiatric Association, 1987. Diagnostic and Statistical Manual of Mental Disorders, Revised third Edition, American Psychiatric Association, Washington, DC.
  2. Belandia B, Latasa MJ, Villa A, Pascual A. Thyroid hormone negatively regulates the transcriptional activity of the beta-amyloid precursor protein gene. J. Biol. Chem. 1998;273:30366–30371
  3. Boelaert K, Franklyn JA. Thyroid hormone in health and disease. J. Endocrinol. 2005;187:1–15
  4. Breteler MM, van Duijn CM, Chandra V, Fratiglioni L, Graves AB, Heyman A, et al. Medical history and the risk of Alzheimer's disease: a collaborative re-analysis of case–control studies. Int. J. Epidemiol. 1991;20(Suppl. 2):S36–S42
  5. Chiovato L, Mariotti S, Pinchera A. Thyroid diseases in the elderly. Baillieres Clin. Endocrinol. Metab. 1997;11:251–270
  6. Chopra IJ, Hershman JM, Pardridge WM, Nicoloff JT. Thyroid function in nonthyroidal illnesses. Ann. Intern. Med. 1983;98:946–957
  7. Chui HC, Victoroff JI, Margolin D, Jagust W, Shankle R, Katzman R. Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers. Neurology. 1992;42:473–480
  8. de Jong FJ, den Heijer T, Visser TJ, de Rijke YB, Drexhage HA, Hofman A, et al. Thyroid hormones, dementia and atrophy of the medial temporal lobe. J. Clin. Endocrinol. Metab. 2006;91:2569–2573
  9. den Heijer T, Geerlings MI, Hoebeek FE, Hofman A, Koudstaal PJ, Breteler MM. Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people. Arch. Gen. Psychiatry. 2006;63:57–62
  10. Dugbartey AT. Neurocognitive aspects of hypothyroidism. Arch. Intern. Med. 1998;158:1413–1418
  11. Ganguli M, Burmeister LA, Seaberg EC, Belle S, DeKosky ST. Association between dementia and elevated TSH: a community-based study. Biol. Psychiatry. 1996;40:714–725
  12. Havlik RJ, Izmirlian G, Petrovitch H, Ross GW, Masaki K, Curb JD, et al. APOE-epsilon4 predicts incident AD in Japanese-American men: the Honolulu Asia Aging Study. Neurology. 2000;54:1526–1529
  13. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J. Lipid Res. 1990;31:545–548
  14. Kalmijn S, Mehta KM, Pols HA, Hofman A, Drexhage HA, Breteler MM. Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clin. Endocrinol. (Oxf). 2000;53:733–737
  15. Latasa MJ, Belandia B, Pascual A. Thyroid hormones regulate beta-amyloid gene splicing and protein secretion in neuroblastoma cells. Endocrinology. 1998;139:2692–2698
  16. Launer LJ. Demonstrating the case that AD is a vascular disease: epidemiologic evidence. Ageing Res. Rev. 2002;1:61–77
  17. Mariotti S, Franceschi C, Cossarizza A, Pinchera A. The aging thyroid. Endocr. Rev. 1995;16:686–715
  18. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939–944
  19. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 1991;41:479–486
  20. Molchan SE, Lawlor BA, Hill JL, Mellow AM, Davis CL, Martinez R, et al. The TRH stimulation test in Alzheimer's disease and major depression: relationship to clinical and CSF measures. Biol. Psychiatry. 1991;30:567–576
  21. Petrovitch H, Nelson J, Snowdon D, Davis DG, Ross GW, Li CY, et al. Microscope field size and the neuropathologic criteria for Alzheimer's disease. Neurology. 1997;49:1175–1176
  22. Petrovitch H, White LR, Ross GW, Steinhorn SC, Li CY, Masaki KH, et al. Accuracy of clinical criteria for AD in the Honolulu–Asia Aging Study, a population-based study. Neurology. 2001;57:226–234
  23. Ross DS. Serum thyroid-stimulating hormone measurement for assessment of thyroid function and disease. Endocrinol. Metab. Clin. North Am. 2001;30:245–264(vii)
  24. SAS Institute Inc., 1999. SAS/STAT Software, version 8.0 for Windows, Cary, NC, SAS Institute Inc.
  25. Scobbo RR, VonDohlen TW, Hassan M, Islam S. Serum TSH variability in normal individuals: the influence of time of sample collection. W.V. Med. J. 2004;100:138–142
  26. Shi ZX, Levy A, Lightman SL. Hippocampal input to the hypothalamus inhibits thyrotrophin and thyrotrophin-releasing hormone gene expression. Neuroendocrinology. 1993;57:576–580
  27. Small GW, Matsuyama SS, Komanduri R, Kumar V, Jarvik LF. Thyroid disease in patients with dementia of the Alzheimer type. J. Am. Geriatr. Soc. 1985;33:538–539
  28. SPSS Inc., 2000. Advanced Statistical Analysis Using SPSS, version 10.0 for Windows, SPSS Inc., Chicago, IL.
  29. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004;291:228–238
  30. Syme SL, Marmot MG, Kagan A, Kato H, Rhoads G. Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: introduction. Am. J. Epidemiol. 1975;102:477–480
  31. Teng EL, Hasegawa K, Homma A, Imai Y, Larson E, Graves A, et al. The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia. Int. Psychogeriatr. 1994;6:45–58(discussion 62)
  32. van Osch LA, Hogervorst E, Combrinck M, Smith AD. Low thyroid-stimulating hormone as an independent risk factor for Alzheimer's disease. Neurology. 2004;62:1967–1971
  33. White L, Petrovitch H, Ross GW, Masaki KH, Abbott RD, Teng EL, et al. Prevalence of dementia in older Japanese-American men in Hawaii: the Honolulu–Asia Aging Study. JAMA. 1996;276:955–960
  34. Yoshimasu F, Kokmen E, Hay ID, Beard CM, Offord KP, Kurland LT. The association between Alzheimer's disease and thyroid disease in Rochester, Minnesota. Neurology. 1991;41:1745–1747

PII: S0197-4580(07)00301-6

doi: 10.1016/j.neurobiolaging.2007.07.019

Neurobiology of Aging
Volume 30, Issue 4 , Pages 600-606 , April 2009

Article Tools

* Image Usage & Resolution