Neurobiology of Aging
Volume 30, Issue 4 , Pages 561-573 , April 2009

Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia

  • Vahram Haroutunian

      Affiliations

    • Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, United States
    • MIRECC, James J. Peters Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, United States
    • Corresponding Author InformationCorresponding author at: Psychiatry Research, 4F-33B, Bronx VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, United States. Tel.: +1 718 584 9000x6082; fax: +1 718 365 9622.
  • ,
  • Pavel Katsel

      Affiliations

    • Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, United States
  • ,
  • James Schmeidler

      Affiliations

    • Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, United States

Received 19 April 2007 ,Revised 16 July 2007 ,Accepted 22 July 2007.

References 

  1. Benjamini Y, Hochberg Y. Controlling the false discovery rate—a practical and powerful approach to multiple testing. J. R. Soc. Ser. B: Methodol. 1995;57:289–300
  2. Blalock EM, Chen KC, Stromberg AJ, Norris CM, Kadish I, Kraner SD, et al. Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation. Ageing Res. Rev. 2005;4:481–512
  3. Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW. Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc. Natl. Acad. Sci. U.S.A. 2004;101:2173–2178
  4. Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br. J. Psychiatry. 1968;114:797–811
  5. Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 2003;19:185–193
  6. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K. Staging of Alzheimer disease-associated neurofibrillarypathology using paraffin sections and immunocytochemistry. Acta Neuropathol. 2006;112:389–404
  7. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl.). 1991;82:239–259
  8. Braak H, Braak E. Staging of Alzheimer-related cortical destruction. Int. Psychogeriatr. 1997;9(Suppl. 1):257–261
  9. Braak H, Tredici KD, Schultz C, Braak E. Vulnerability of select neuronal types to Alzheimer's disease. Ann. N.Y. Acad. Sci. 2002;924:53–61
  10. Bussiere T, Gold G, Kovari E, Giannakopoulos P, Bouras C, Perl DP, et al. Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease. Neuroscience. 2003;117:577–592
  11. Davis KL, Mohs RC, Marin D, Purohit DP, Perl DP, Lantz M, et al. Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA. 1999;281:1401–1406
  12. Davis KL, Mohs RC, Marin DB, Purohit DP, Perl DP, Lantz M, et al. Cholinergic markers are not decreased in early Alzheimer's disease. JAMA. 1999;281:1401–1406
  13. Davis KL, Mohs RC, Marin DB, Purohit DP, Perl DP, Lantz M, et al. Neuropeptide abnormalities in patients with early Alzheimer disease. Arch. Gen. Psychiatry. 1999;56:981–987
  14. Dooneief G, Marder K, Tang MX, Stern Y. The Clinical Dementia Rating scale: community-based validation of “profound’ and “terminal’ stages. Neurology. 1996;46:1746–1749
  15. Emilsson L, Saetre P, Jazin E. Alzheimer's disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling. Neurobiol. Dis. 2006;21:618–625
  16. Giannakopoulos P, Herrmann FR, Bussiere T, Bouras C, Kovari E, Perl DP, et al. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology. 2003;60:1495–1500
  17. Ginsberg SD, Che S, Counts SE, Mufson EJ. Single cell gene expression profiling in Alzheimer's disease. NeuroRx. 2006;3:302–318
  18. Ginsberg SD, Elarova I, Ruben M, Tan F, Counts SE, Eberwine JH, et al. Single-cell gene expression analysis: implications for neurodegenerative and neuropsychiatric disorders. Neurochem. Res. 2004;29:1053–1064
  19. Ginsberg SD, Hemby SE, Lee VM, Eberwine JH, Trojanowski JQ. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann. Neurol. 2000;48:77–87
  20. Hardy J. A hundred years of Alzheimer's disease research. Neuron. 2006;52:3–13
  21. Haroutunian V, Davies PJ, Vianna C, Buxbaum JD, Purohit DP. Tau protein abnormalities associated with the progression of Alzheimer disease type dementia. Neurobiol. Aging. 2006;28:1–7
  22. Haroutunian V, Davis KL. Pathophysiology of dementia. In:  Tasman A,  Kay J,  Lieberman J editor. Psychiatry. vol. 1:Chichester, England: John Wiley & Sons; 2003;p. 338–349
  23. Haroutunian V, Perl DP, Purohit DP, Marin D, Khan K, Lantz M, et al. Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease. Arch. Neurol. 1998;55:1185–1191
  24. Haroutunian V, Purohit DP, Perl DP, Marin D, Khan K, Lantz M, et al. Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease. Arch. Neurol. 1999;56:713–718
  25. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4:249–264
  26. Katsel P, Davis KL, Gorman JM, Haroutunian V. Variations in differential gene expression patterns across multiple brain regions in schizophrenia. Schizo. Res. 2005;77:241–252
  27. Katsel P, Davis KL, Haroutunian V. Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions: a gene ontology study. Schizo. Res. 2005;79:157–173
  28. Katsel PL, Davis KL, Haroutunian V. Large-scale microarray studies of gene expression in multiple regions of the brain in schizophrenia and Alzheimer's disease. Int. Rev. Neurobiol. 2005;63:41–82
  29. Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch. Neurol. 1985;42:1097–1105
  30. Loring JF, Wen X, Lee JM, Seilhamer J, Somogyi R. A gene expression profile of Alzheimer's disease. DNA Cell Biol. 2001;20:683–695
  31. Masliah E, Miller A, Terry RD. The synaptic organization of the neocortex in Alzheimer's disease. Med. Hypotheses. 1993;41:334–340
  32. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 1991;41:479–486
  33. Morris JC. The clinical dementia rating (CDR): current version and scoring rules. Neurology. 1993;43:2412–2414
  34. Morris JC, Storandt M, Miller JP, McKeel DW, Price JL, Rubin EH, et al. Mild cognitive impairment represents early-stage Alzheimer disease. Arch. Neurol. 2001;58:397–405
  35. Morrison JH, Hof PR, Rapp PR. Neuropathology of normal aging in cerebral cortex. In:  Beal MF,  Lang AE,  Ludolph A editor. Neurodegenerative Diseases. Cambridge: Cambridge University Press; 2005;p. 396–406
  36. Naslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA. 2000;283:1571–1577
  37. Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, et al. Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiol. Aging. 2006;[Epub ahead of print]
  38. Parvathy S, Davies P, Haroutunian V, Purohit DP, Davis KL, Mohs RC, et al. Correlation between Abetax-40-, Abetax-42-, and Abetax-43-containing amyloid plaques and cognitive decline. Arch. Neurol. 2001;58:2025–2032
  39. Pasinetti GM. Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia. J. Neurosci. Res. 2001;65:471–476
  40. Price JL, Ko AI, Wade MJ, Tsou SK, McKeel DW, Morris JC. Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch. Neurol. 2001;58:1395–1402
  41. Price JL, Morris JC. Tangles and plaques in nondemented aging and “preclinical” Alzheimer's disease. Ann. Neurol. 1999;45:358–368
  42. Rapp MA, Schnaider-Beeri M, Sano M, Silverman J, Haroutunian V. The relationship of neuropsychological performance to functional status in old age: a comparison of nursing home residents and community dwellers. Am. J. Geriatr. Psychiatry. 2005;13:450–459
  43. Ricciarelli R, d’Abramo C, Massone S, Marinari U, Pronzato M, Tabaton M. Microarray analysis in Alzheimer's disease and normal aging. IUBMB Life. 2004;56:349–354
  44. Roberson ED, Mucke L. 100 years and counting: prospects for defeating Alzheimer's disease. Science. 2006;314:781–784
  45. Stern Y, Liu X, Albert M, Brandt J, Jacobs DM, Castillo-Castaneda C, et al. Application of a growth curve approach to modeling the progression of Alzheimer's disease. J. Gerontol A: Biol. Sci. Med. Sci. 1996;51:M179–M184
  46. Terry RD. Alzheimer's disease and the aging brain. J. Geriatr. Psychiatry Neurol. 2006;19:125–128
  47. Tomlinson BE, Blessed G, Roth M. Observations on the brains of demented old people. J. Neurol. Sci. 1970;11:205–242
  48. Uboga NV, Price JL. Formation of diffuse and fibrillar tangles in aging and early Alzheimer's disease. Neurobiol. Aging. 2000;21:1–10
  49. Von Gunten A, Kovari E, Rivara CB, Bouras C, Hof PR, Giannakopoulos P. Stereologic analysis of hippocampal Alzheimer's disease pathology in the oldest-old: evidence for sparing of the entorhinal cortex and CA1 field. Exp. Neurol. 2005;193:198–206
  50. Xu PT, Li YJ, Qin XJ, Scherzer CR, Xu H, Schmechel DE, et al. Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Neurobiol. Dis. 2006;21:256–275
  51. Yao PJ, Zhu M, Pyun EI, Brooks AI, Therianos S, Meyers VE, et al. Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease. Neurobiol. Dis. 2003;12:97–109

 Although we are unable at this time to publish the entire array data set, we are committed to sharing the gene expression data broadly with our academic colleagues. We will be happy to collaborate with interested investigators and to interrogate the data set for the expression levels of genes of interest.

PII: S0197-4580(07)00296-5

doi: 10.1016/j.neurobiolaging.2007.07.021

Neurobiology of Aging
Volume 30, Issue 4 , Pages 561-573 , April 2009