Neurobiology of Aging
Volume 29, Issue 10 , Pages 1502-1511 , October 2008

Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice

  • Pu Wu

      Affiliations

    • Shanghai Institute of Brain Functional Genomics, MOE & STCSM Key Lab of Brain Functional Genomics, East China Normal University, Shanghai 200062, China
    • ,
  • Qian Shen

      Affiliations

    • Shanghai Institute of Brain Functional Genomics, MOE & STCSM Key Lab of Brain Functional Genomics, East China Normal University, Shanghai 200062, China
    • ,
  • Suzhen Dong

      Affiliations

    • Shanghai Institute of Brain Functional Genomics, MOE & STCSM Key Lab of Brain Functional Genomics, East China Normal University, Shanghai 200062, China
    • ,
  • Zhiliang Xu

      Affiliations

    • Center for Systems Neurobiology, Departments of Pharmacology and Biomedical Engineering, Boston University, Boston, MA 02118, USA
    • ,
  • Joe Z. Tsien

      Affiliations

    • Center for Systems Neurobiology, Departments of Pharmacology and Biomedical Engineering, Boston University, Boston, MA 02118, USA
    • ,
  • Yinghe Hu

      Affiliations

    • Shanghai Institute of Brain Functional Genomics, MOE & STCSM Key Lab of Brain Functional Genomics, East China Normal University, Shanghai 200062, China
    • Corresponding Author InformationCorresponding author at: Key Lab of Brain Functional Genomics, MOE & STCSM, Shanghai Institute of Brain Functional Genomics, East China Normal University, 3663 Zhongshan Road N. Shanghai 200062, China. Tel.: +86 21 62603004; fax: +86 21 62601953.

Received 6 October 2006 ,Revised 16 March 2007 ,Accepted 30 March 2007.

References 

  1. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, et al. Inflammation and Alzheimer's disease. Neurobiol. Aging. 2000;21:383–421
  2. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337–342
  3. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug. Discov. 2006;5:493–506
  4. Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J. Biol. Chem. 2004;279:46907–46914
  5. Bruce-Keller AJ, Umberger G, McFall R, Mattson MP. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann. Neurol. 1999;45:8–15
  6. Cinelli P, Madani R, Tsuzuki N, Vallet P, Arras M, Zhao CN, et al. Neuroserpin, a neuroprotective factor in focal ischemic stroke. Mol. Cell. Neurosci. 2001;18:443–457
  7. De Strooper B. Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex. Neuron. 2003;38:9–12
  8. Duan W, Guo Z, Jiang H, Ware M, Li XJ, Mattson MP. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc. Natl. Acad. Sci. U.S.A. 2003;100:2911–2916
  9. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. U.S.A. 1998;95:14863–14868
  10. Feng R, Wang H, Wang J, Shrom D, Zeng X, Tsien JZ. Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proc. Natl. Acad. Sci. U.S.A. 2004;101:8162–8167
  11. Guarente L, Picard F. Calorie restriction—the SIR2 connection. Cell. 2005;120:473–482
  12. Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 1997;20:154–159
  13. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002;297:353–356
  14. Hosack DA, Dennis G, Sherman BT, Lane HC, Lempicki RA. Identifying biological themes within lists of genes with EASE. Genome Biol. 2003;4:R70
  15. Ingram DK, Weindruch R, Spangler EL, Freeman JR, Walford RL. Dietary restriction benefits learning and motor performance of aged mice. J. Gerontol. 1987;42:78–81
  16. Jiang CH, Tsien JZ, Schultz PG, Hu Y. The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc. Natl. Acad. Sci. U.S.A. 2001;98:1930–1934
  17. Jin K, Mao XO, Sun Y, Xie L, Greenberg DA. Stem cell factor stimulates neurogenesis in vitro and in vivo. J. Clin. Invest. 2002;110:311–319
  18. Katzman R. Alzheimer's disease. N. Engl. J. Med. 1986;314:964–973
  19. Kopan R, Ilagan MX. Gamma-secretase: proteasome of the membrane?. Nat. Rev. Mol. Cell. Biol. 2004;5:499–504
  20. Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 1986;83:4044–4048
  21. Lee CK, Weindruch R, Prolla TA. Gene-expression profile of the ageing brain in mice. Nat. Genet. 2000;25:294–297
  22. Lee J, Duan W, Long JM, Ingram DK, Mattson MP. Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. J. Mol. Neurosci. 2000;15:99–108
  23. Li X, Yang Q, Hu Y. Gene expression profiling reveals the mechanism of action of anticonvulsant drug QYS. Brain Res. Bull. 2005;66:99–105
  24. Mattson MP. Pathways towards and away from Alzheimer's disease. Nature. 2004;430:631–639
  25. Mattson MP, Chan SL, Duan W. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol. Rev. 2002;82:637–672
  26. Mattson MP, Guo Q, Furukawa K, Pedersen WA. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J. Neurochem. 1998;70:1–14
  27. Patel NV, Gordon MN, Connor KE, Good RA, Engelman RW, Mason J, et al. Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models. Neurobiol. Aging. 2005;26:995–1000
  28. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature. 1999;402:615–622
  29. Pitsikas N, Algeri S. Deterioration of spatial and non-spatial reference and working memory in aged rats: protective effect of life-long calorie restriction. Neurobiol. Aging. 1992;13:369–373
  30. Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, et al. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J. Biol. Chem. 2006;281:21745–21754
  31. Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science. 2005;309:476–481
  32. Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, et al. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron. 2004;42:23–36
  33. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, et al Cloning of a gene bearing missense mutations in early onset familial Alzheimer's disease. Nature. 1995;375:754–760
  34. Tenner AJ. Complement in Alzheimer's disease: opportunities for modulating protective and pathogenic events. Neurobiol. Aging. 2001;22:849–861
  35. Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW. Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. J. Gerontol. A: Biol. Sci. Med. Sci. 1999;54:B492–B501
  36. Wang J, Ho L, Qin W, Rocher AB, Seror I, Humala N, et al. Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. Faseb. J. 2005;19:659–661
  37. Wang J, Ho L, Zhao Z, Seror I, Humala N, Dickstein DL, et al. Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease. Faseb. J. 2006;20:2313–2320
  38. Winsky-Sommerer R, Spier AD, Fabre V, de Lecea L, Criado JR. Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice. Brain Res. 2004;1023:157–162
  39. Wu P, Hu YH. Definition of genes and paths involved in Alzheimer's disease: using gene expression profiles and chemical genetics at the mouse brain level. Curr. Genom. 2006;7:293–300
  40. Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 2000;407:802–809

PII: S0197-4580(07)00137-6

doi: 10.1016/j.neurobiolaging.2007.03.028

Neurobiology of Aging
Volume 29, Issue 10 , Pages 1502-1511 , October 2008

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