« Previous
Next »
Neurobiology of Aging
Volume 29, Issue 10
, Pages 1474-1484
, October 2008
Enhanced proteasome-dependent degradation of the CDK inhibitor p27kip1 in immortalized lymphocytes from Alzheimer's dementia patients
References
- . BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells. Cancer Res. 2005;65:3264–3272
- . Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the ‘Dr. Jekyll and Mr. Hyde concept’ of Alzheimer's disease or the yin and yang of neuroplasticity. Prog. Neurobiol. 2003;71:83–248
- . Peripheral proteasome and caspase activity in Parkinson disease and Alzheimer disease. Neurology. 2006;66:529–534
- . Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin. Cancer Biol. 2003;13:41–47
- . A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J. 2002;21:3390–3401
- . Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle. J. Alzheimers Dis. 2002;4:249–254
- . A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. J. Clin. Invest. 1999;104:815–823
- . Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?. Trends Neurosci. 2001;24:25–31
- . Ca2+/calmodulin-dependent modulation of cell cycle elements pRb and p27kip1 involved in the enhanced proliferation of lymphoblasts from patients with Alzheimer dementia. Neurobiol. Dis. 2003;13:254–263
- . Calmodulin-mediated activation of Akt regulates survival of c-Myc-overexpressing mouse mammary carcinoma cells. J. Biol. Chem. 2004;279:38903–38911
- . Protein quality control in Alzheimer's disease by the ubiquitin proteasome system. Prog. Neurobiol. 2004;74:249–270
- . Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells. J. Biol. Chem. 1997;272:182–188
- . Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol. Cell. Biol. 2000;20:9138–9148
- . A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell. 1996;85:733–744
- . High affinity calmodulin target sequence in the signalling molecule PI 3-kinase. FEBS Lett. 1998;425:175–177
- . Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J. Neurochem. 2005;93:105–117
- . Translational control of p27Kip1 accumulation during the cell cycle. Science. 1996;271:1861–1864
- . Divide and die: cell cycle events as triggers of nerve cell death. J. Neurosci. 2004;24:9232–9239
- . Altered Ca2+ homeostasis in lymphoblasts from patients with late-onset Alzheimer disease. Alzheimer Dis. Assoc. Disord. 1997;11:220–227
- . Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. J. Biol. Chem. 2000;275:25146–25154
- . Calmodulin activates phosphatidylinositol 3-kinase. J. Biol. Chem. 1997;272:28183–28186
- . Impaired proteasome function in Alzheimer's disease. J. Neurochem. 2000;75:436–439
- . Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J. Biol. Chem. 2005;280:1095–1102
- . HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways. Cell Cycle. 2005;4:87–95
- . PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Proc. Natl. Acad. Sci. U.S.A. 1998;95:15406–15411
- . PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat. Med. 2002;8:1153–1160
- . Calcineurin is a common target of cyclophilin–cyclosporin A and FKBP–FK506 complexes. Cell. 1991;66:807–815
- . PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development. 2002;129:3513–3522
- . Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am. J. Pathol. 1997;150:933–939
- . A U-rich element in the 5′ untranslated region is necessary for the translation of p27 mRNA. Mol. Cell. Biol. 2000;20:5947–5959
- . Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood. 2002;99:4079–4086
- . Free full text complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. Am. J. Pathol. 2005;166:737–749
- . The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. Exp. Neurol. 2005;195:508–517
- . Cell cycle kinesis in lymphocytes in the diagnosis of Alzheimer's disease. Neurosci. Lett. 2002;317:81–84
- . The cell division cycle and the pathophysiology of Alzheimer's disease. Neuroscience. 1998;87:731–739
- . Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 2000;19:2069–2081
- . Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995;269:682–685
- . Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway. J. Biol. Chem. 2004;279:6132–6142
- . Cyclin’ toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease. J. Neurosci. Res. 2000;61:128–133
- . Akt activity in Alzheimer's disease and other neurodegenerative disorders. Neuroreport. 2004;15:955–959
- . Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev. 1997;11:1464–1478
- . Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 1995;9:1149–1163
- . PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat. Med. 2002;8:1145–1152
- . Regulation of the cdk inhibitor p27 and its deregulation in cancer. J. Cell. Physiol. 2000;183:10–17
- . Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways. J. Neurosci. 2002;22:7380–7388
- . Impairment of mitogenic activation of peripheral blood lymphocytes in Alzheimer's disease. Neuroreport. 2001;12:3969–3972
- . Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science. 1997;277:567–570
- . Cell-cycle-dependent abnormal calcium response in fibroblasts from patients with familial Alzheimer's disease. Dementia. 1995;6:9–16
- . KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-l-tyrosyl]-4-phenylpiperazine, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 1990;265:4315–4320
- . Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. Nature. 1999;398:160–185
- . p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr. Biol. 1999;9:661–664
- . Enhanced proliferation of lymphoblasts from patients with Alzheimer dementia associated with calmodulin-dependent activation of the Na+/H+ exchanger. Neurobiol. Dis. 2001;8:289–298
- . Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat. Med. 2002;8:1136–1144
- . The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mech. Ageing Dev. 2005;126:1019–1025
- . Alzheimer's disease: the two-hit hypothesis. Lancet Neurol. 2004;3:219–226
PII: S0197-4580(07)00123-6
doi: 10.1016/j.neurobiolaging.2007.03.013
© 2007 Elsevier Inc. All rights reserved.
« Previous
Next »
Neurobiology of Aging
Volume 29, Issue 10
, Pages 1474-1484
, October 2008
