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Neurobiology of Aging
Volume 29, Issue 8
, Pages 1167-1176
, August 2008
A SNP in the ACT gene associated with astrocytosis and rapid cognitive decline in AD
References
- . Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell. 1988;52:487–501
- . Effects of Alzheimer's peptide and alpha1-antichymotrypsin on astrocyte gene expression. Neurobiol. Aging. 2007;28:51–61
- . Molecular evolution of serpins: Homologous structure of the human alpha 1-antichymotrypsin and alpha 1-antitrypsin genes. Biochemistry. 1987;26:7755–7759
- Bertram, L., Tanzi, R. E. (2004). Alzheimer's disease: One disorder, too many genes? Hum. Mol. Genet. ddh077.
- . Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin iii. Biochemistry. 1983;22:5055–5061
- . Haplotypes of the alpha-1 antitrypsin gene in healthy controls and z deficiency patients. Hum. Mutat. 2004;24:535–536
- . Cryptic haplotypes of serpina1 confer susceptibility to chronic obstructive pulmonary disease. Hum. Mutat. 2006;27:103–109
- . Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 1992;360:672–674
- . Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921–923
- . Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 2003;25:115–121
- . Alpha 1-antichymotrypsin regulates alzheimer beta-amyloid peptide fibril formation. Proc. Natl. Acad. Sci. USA. 1995;92:2313–2317
- . Alpha-antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the spanish population. Neurosci. Lett. 1998;240:107–109
- . Alpha 1-antichymotrypsin binding to alzheimer a beta peptides is sequence specific and induces fibril disaggregation in vitro. J. Neurochem. 1993;61:298–305
- . No genetic effect of alpha1-antichymotrypsin in alzheimer disease. Genomics. 1996;33:53–56
- . A haplotype map of the human genome. Nature. 2005;437:1299–1320
- . Absence of association of alpha1-antichymotrypsin polymorphisms with Alzheimer's disease: a report on autopsy-confirmed cases. Exp. Neurol. 1998;151:237–240
- . Visualization of a beta 42(43) and a beta 40 in senile plaques with end-specific a beta monoclonals: evidence that an initially deposited species is a beta 42(43). Neuron. 1994;13:45–53
- . A specific structural interaction of Alzheimer's peptide a beta 1-42 with alpha 1-antichymotrypsin. Nat. Struct. Biol. 1996;3:668–671
- . Alzheimer's peptide abeta1-42 binds to two beta-sheets of alpha1-antichymotrypsin and transforms it from inhibitor to substrate. J. Biol. Chem. 1998;273:28360–28364
- . Apoe*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism. Nat. Genet. 1995;10:486–488
- . Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis. J. Biol. Chem. 2002;277:15666–15670
- . Oncostatin m and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes. J. Biol. Chem. 1998;273:4112–4118
- . Mechanism of interleukin-1- and tumor necrosis factor alpha-dependent regulation of the alpha 1-antichymotrypsin gene in human astrocytes. J. Neurosci. 2000;20:7510–7516
- . Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with lewy bodies. Distinctions between diseases. Neurology. 1998;50:388–391
- . Using meta-analysis to explain the diversity of results in genetic studies of late-onset Alzheimer's disease and to identify high-risk subgroups. Neuroscience. 2001;108:541–554
- . Gene polymorphism affecting alpha1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk. Ann. Neurol. 2000;48:388–391
- . A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease. Neurobiol. Aging. 2005;26:449–453
- . Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of alzheimer beta-protein into filaments. Nature. 1994;372:92–94
- . Alzheimer a beta neurotoxicity: Promotion by antichymotrypsin, apoe4; inhibition by a beta-related peptides. Neurobiol. Aging. 1996;17:773–780
- . Apoe alleles predict the rate of cognitive decline in alzheimer disease: a nonlinear model. Neurology. 2005;65:1888–1893
- . Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists. Arch. Pathol. Lab. Med. 1993;117:132–144
- . Polymorphism in the alpha(1)-antichymotrypsin (ACT) gene promoter: effect on expression in transfected glial and liver cell lines and plasma ACT concentrations. Hum. Genet. 2001;109:303–310
- . Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice. Am. J. Pathol. 2000;157:2003–2010
- . No association between the alpha 1-antichymotrypsin a allele and Alzheimer's disease. Neurology. 1997;48:1313–1316
- . Accuracy of clinical operational diagnostic criteria for Alzheimer's disease in relation to different pathological diagnostic protocols. Dement. Geriatr. Cogn. Disord. 1998;9:219–226
- . Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease. J. Neurosci. 2001;21:1444–1451
- . Effect of cytokines, dexamethasone and the a/t-signal peptide polymorphism on the expression of alpha(1)-antichymotrypsin in astrocytes: significance for Alzheimer's disease. Neurochem. Int. 2001;39:361–370
- . Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation. Neurobiol. Aging. 2004;25:1153–1167
- . Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mrna. Am. J. Pathol. 1989;135:827–834
- . Mixed-Effects Models in s and s-Plus. Springer; 2000;
- . A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease. Genomics. 1993;17:740–743
- . The Cambridge Examination for Mental Disorders of the Elderly. Camdex: Cambridge University Press; 1988;
- . Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am. J. Hum. Genet. 2002;70:425–434
- . Glioma cell activation by Alzheimer's peptide abeta1-42, alpha1-antichymotrypsin, and their mixture. Cell. Mol. Life Sci. 2002;59:1734–1743
- . Polymorphism in aact gene may lower age of onset of Alzheimer's disease. Neuroreport. 1996;7:534–536
- . Tau load is associated with apolipoprotein E genotype and the amount of amyloid beta protein, abeta40, in sporadic and familial Alzheimer's disease. Neuropathol. Appl. Neurobiol. 2003;29:35–44
- . Alpha-1-antichymotrypsin bi-allele polymorphism, apolipoprotein-E tri-allele polymorphism and genetic risk of Alzheimer's syndrome. J. Neural. Transm. Park Dis. Dement. Sect. 1995;10:207–212
- . Human plasma proteinase inhibitors. Annu. Rev. Biochem. 1983;52:655–709
- . Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease. Hum. Genet. 2002;110:356–365
- . Alpha 1-antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in japanese apolipoprotein E epsilon 4 allele carriers. Ann. Neurol. 1997;42:115–117
- . Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer's disease. Neurosci. Lett. 2004;362:99–102
PII: S0197-4580(07)00060-7
doi: 10.1016/j.neurobiolaging.2007.02.021
© 2007 Elsevier Inc. All rights reserved.
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Neurobiology of Aging
Volume 29, Issue 8
, Pages 1167-1176
, August 2008
