Neurobiology of Aging
Volume 29, Issue 8 , Pages 1199-1203 , August 2008

Increased hippocampal atrophy rates in AD over 6 months using serial MR imaging

  • J. Barnes

      Affiliations

    • Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom
    • Corresponding Author InformationCorresponding author at: Dementia Research Centre, Box 16, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom. Tel.: +44 845 155 5000x723804; fax: +44 20 7676 2066.
    • ,
  • R.I. Scahill

      Affiliations

    • Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom
    • ,
  • C. Frost

      Affiliations

    • Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom
    • London School of Hygiene and Tropical Medicine, London, United Kingdom
    • ,
  • J.M. Schott

      Affiliations

    • Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom
    • ,
  • M.N. Rossor

      Affiliations

    • Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom
    • Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College, London, United Kingdom
    • ,
  • N.C. Fox

      Affiliations

    • Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom

Received 28 November 2006 ,Revised 15 January 2007 ,Accepted 5 February 2007.

References 

  1. Bradley KM, Bydder GM, Budge MM, Hajnal JV, White SJ, Ripley BD, et al. Serial brain MRI at 3–6 month intervals as a surrogate marker for Alzheimer's disease. Br. J. Radiol. 2002;75:506–513
  2. Dawbarn D, Allen SJ. Neurobiology of Alzheimer's Disease. second ed.. Oxford University Press; 2001;
  3. Duvernoy HM. The Human Hippocampus. second ed.. Springer-Verlag; 1998;
  4. Fox NC, Scahill RI, Crum WR, Rossor MN. Correlation between rates of brain atrophy and cognitive decline in AD. Neurology. 1999;52:1687–1689
  5. Freeborough PA, Fox NC, Kitney RI. Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans. Comput. Methods Programs Biomed. 1997;53:15–25
  6. Jack CR, Slomkowski M, Gracon S, Hoover TM, Felmlee JP, Stewart K, et al. MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD. Neurology. 2003;60:253–260
  7. Kantarci K, Jack CR. Quantitative magnetic resonance techniques as surrogate markers of Alzheimer's disease. NeuroRx. 2004;1:196–205
  8. Krishnan KR, Charles HC, Doraiswamy PM, Mintzer J, Weisler R, Yu X, et al. Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease. Am. J. Psychiatry. 2003;160:2003–2011
  9. Mazziotta JC, Toga AW, Evans A, Fox P, Lancaster J. A probabilistic atlas of the human brain: theory and rationale for its development. Neuroimage. 1995;2:89–101
  10. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's Disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939–944
  11. Scahill RI, Frost C, Jenkins R, Whitwell JL, Rossor MN, Fox NC. A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch. Neurol. 2003;60:989–994
  12. Schott JM, Price SL, Frost C, Whitwell JL, Rossor MN, Fox NC. Measuring atrophy in Alzheimer disease—a serial MRI study over 6 and 12 months. Neurology. 2005;65:119–124
  13. Watson C, Andermann F, Gloor P, Jones-Gotman M, Peters T, Evans A, et al. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology. 1992;42:1743–1750
  14. Whitwell JL, Schott JM, Lewis EB, MacManus DG, Fox NC. Using nine degrees-of-freedom registration to correct for changes in voxel size in serial MRI studies. Magn. Reson. Imaging. 2004;22:993–999

PII: S0197-4580(07)00050-4

doi: 10.1016/j.neurobiolaging.2007.02.011

Neurobiology of Aging
Volume 29, Issue 8 , Pages 1199-1203 , August 2008

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