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Neurobiology of Aging
Volume 29, Issue 7
, Pages 1052-1059
, July 2008
Reversion of age-related recognition memory impairment by iron chelation in rats
References
- . Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidants. Biochem. Biophys. Res. Commun. 2005;336(2):386–391
- . Of metals, mice, and men: what animal models can teach us about body iron loading. J. Clin. Invest. 2000;105(9):1185–1186
- . MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's disease. Cell Mol. Biol. (Noisy-le-grand). 2000;46(4):821–833
- . Increased basal ganglia iron levels in Huntington disease. Arch. Neurol. 1999;56(5):569–574
- . Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain. J. Comp. Neurol. 1993;338:97–113
- . The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons. J. Neurochem. 1991;56(4):1441–1444
- . The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity. J. Pharmacol. Toxicol. Methods. 2006;54(2):99–105
- . Iron: a pathological mediator of Alzheimer disease?. Dev. Neurosci. 2002;24:184–187
- . Studies on lipid peroxidation and protein oxidation in the aging brain. Neurobiol. Aging. 1995;16(1):53–57
- . A quantitative analysis of isoferritins in select regions of the aged, parkinsonian and Alzheimer Disease brains. J. Neurochem. 1995;65:717–724
- . Intramuscular desferrioxamine in patients with Alzheimer's disease. Lancet. 1991;338(8762):324–326
- . Neonatal iron exposure induces oxidative stress in adult Wistar rats. Dev. Brain Res. 2001;130:109–114
- . Temporary inactivation reveals an essential role of the dorsal hippocampus in consolidation of object recognition memory. Neurosci. Lett. 2006;405(1–2):142–146
- . Recognition memory impairment and brain oxidative stress induced by postnatal iron administration. Eur. J. Neurosci. 2005;21(9):2521–2528
- . Selegiline protects against recognition memory impairment induced by neonatal iron treatment. Exp. Neurol. 2005;196(1):177–183
- . Reversal of age-related deficits in object recognition memory in rats with l-deprenyl. Exp. Gerontol. 2005;40(6):506–511
- . Increased nigral iron content and alteration in other metal ions occurring in brain in Parkinson's disease. J. Neurochem. 1994;52:1830–1836
- . Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain. 1991;114(Pt 4):1953–1975
- . Extending the spontaneous preference test of recognition: evidence of object-location and object-location and object-context recognition. Behav. Brain Res. 1999;99:191–200
- . Oxidative stress and oxidant therapy in Parkinson's disease. Prog. Neurobiol. 1996;48:1–19
- . A new one-trial test for neurobiological studies of memory in rats. I. Behavioral data. Behav. Brain Res. 1988;31:47–59
- . Current status of metals as therapeutic targets in Alzheimer's disease. J. Am. Geriatr. Soc. 2003;51:1143–1148
- . Neonatal iron exposure induces neurobehavioural dysfunctions in adult mice. Toxicol. Appl. Pharmacol. 1999;159:25–30
- . Maze learning and motor activity deficits in adult mice induced by iron exposure during a critical postnatal period. Dev. Brain Res. 2000;119:65–74
- . Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat. Eur. J. Neurosci. 2006;23(7):1757–1765
- . Oxidized protein degradation and repair in ageing and oxidative stress. FEBS Lett. 2006;580:2910–2916
- . MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice. Brain Res. 2003;971(1):95–106
- . Iron in the basal ganglia in Parkinson's disease. An in vivo study using extended X-ray absorption fine structure and cryo-electron microscopy. Brain. 1999;122(4):667–673
- . The effect of aging on the non-haemin iron in the human brain. J. Neurochem. 1958;3:41–51
- . Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss. Am. J. Neuroradiol. 2006;27(2):430–439
- . Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron. 2003;37(6):899–909
- . The role of transition metals in the pathogenesis of Parkinson's disease. J. Neurol. Sci. 1995;134:69–78
- . Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats. Neurobiol. Aging. 2006;27(9):1289–1297
- . Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice. J. Neural Transm. 1997;104:469–481
- . Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990;186:464–478
- . Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc. Natl. Acad. Sci. U.S.A. 2003;100:8526–8531
- . Deferoxamine improves spatial memory performance following experimental brain injury in rats. Brain Res. 1996;717(1–2):109–117
- . Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951;193:265–275
- . Oxidative processes in Alzheimer's disease: the role of Abeta–metal interactions. Exp. Gerontol. 2000;35:445–451
- . Oxidative damage and age-related functional declines. Mech. Ageing Dev. 2006;127:411–423
- . Increasing striatal iron content associated with normal aging. Mov. Disord. 1998;13:281–286
- . N-Acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria. Brain Res. 2000;855(1):100–106
- . Effect of aging on the blood–brain barrier. Neurobiol. Aging. 1988;9(1):31–39
- . Differential contributions of hippocampus, amygdala and perirhinal cortex to recognition of novel objects, contextual stimuli and stimulus relationships. Brain Res. Bull. 2005;67(1–2):62–76
- . Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. Learn. Mem. 2002;9(2):49–57
- . Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats. Behav. Brain Res. 2001;127:159–181
- . Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents. Neuroscience. 2001;107(3):415–431
- . Iron, neuroinflammation, and Alzheimer's disease. J. Alzheimers Dis. 2005;8(2):183–200(discussion 209–15)
- . Effect of alpha-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity. Brain Res. 2006;1109(1):176–182
- . Iron as the malignant spirit in successful ageing. Ageing Res. Rev. 2003;2:25–37
- . Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch. Neurol. 2002;59(6):972–976
- . Brain iron transport and neurodegeneration. Trends Mol. Med. 2001;7(3):103–108
- . Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level. J. Struct. Biol. 2006;153(1):42–54
- . Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat. Neurosci. 2000;3(3):238–244
- . Treatment of Alzheimer's disease with clioquinol. Dement. Geriatr. Cogn. Disord. 2001;12(6):408–414
- . Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions. Ann. NY Acad. Sci. 2004;1012:326–341
- . Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J. Neurochem. 1989;52:515–520
- . Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch. Neurol. 2003;60(12):1685–1691
- . Brain iron deposition and the free radical-mitochondrial theory of ageing. Ageing Res. Rev. 2004;3:265–301
- . Memory deficits in adult rats following postnatal iron administration. Behav. Brain. Res. 2001;124:77–85
- . Neurotoxic methamphetamine regimen severely impairs recognition memory in rats. Synapse. 2003;49:89–96
- . Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lesion in rats. Neuropharmacology. 2004;46(2):254–263
- . Age-related changes in the blood–brain barrier. Exp. Gerontol. 1997;32(4–5):501–519
- . Neurodegenerative disease and iron storage in the brain. Curr. Opin. Neurol. 2004;17(4):437–442
- . Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat. Neurobiol. Aging. 2002;23(1):135–143
- . The hippocampus supports both the recollection and the familiarity components of recognition memory. Neuron. 2006;49(3):459–466
- . Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage. Acta Neurochir. Suppl. 2006;96:199–202
- . Brain iron in the ferrocene-loaded rat: its chelation and influence on dopamine metabolism. Biochem. Pharmacol. 1995;49:1821–1826
- . Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28. Ann. NY Acad. Sci. 2004;1012:306–325
- . Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes. J. Neurochem. 2001;76:1766–1773
- . Iron, brain ageing and neurodegenerative disorders. Nat. Rev. Neurosci. 2004;5(11):863–873
- . Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism. J. Struct. Biol. 2005;150(2):144–153
- . Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration. Biochem. Biophys. Res. Commun. 2005;333(2):544–549
PII: S0197-4580(07)00048-6
doi: 10.1016/j.neurobiolaging.2007.02.006
© 2007 Elsevier Inc. All rights reserved.
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Neurobiology of Aging
Volume 29, Issue 7
, Pages 1052-1059
, July 2008
