Neurobiology of Aging
Volume 29, Issue 7 , Pages 1002-1010 , July 2008

Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics

  • Shannon L. Bianchi
  • ,
  • Thuy Tran
  • ,
  • ChuiLiang Liu

      Affiliations

    • Permanent Address: Department of Anesthesia, T.C.M Hospital of Guangdong Province, Giangzhou 510120, China.
  • ,
  • Susan Lin
  • ,
  • Yujuan Li

      Affiliations

    • Permanent Address: Department of Anesthesia, Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China.
  • ,
  • Jason M. Keller

      Affiliations

    • Present Address: National Institute of Dental and Craniofacial Research (NIDCR), Div. PNMB, Rm 1W15, National Institutes of Health, Bethesda, MD 20892-2190.
  • ,
  • Roderic G. Eckenhoff
  • ,
  • Maryellen F. Eckenhoff

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1 215 662 3705; fax: +1 215 349 5708.

Received 21 September 2006 ,Revised 17 January 2007 ,Accepted 5 February 2007.

References 

  1. Abildstrom H, Rasmussen LS, Rentowl P, Hanning CD, Rasmussen H, Kristensen PA, et al. Cognitive dysfunction 1–2 years after non-cardiac surgery in the elderly. ISPOCD group. International Study of Post-Operative Cognitive Dysfunction. Acta Anaesthesiol. Scand. 2000;44(10):1246–1251
  2. Ancelin ML, de Roquefeuil G, Ledesert B, Bonnel F, Cheminal JC, Ritchie K. Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology in the elderly. Br. J. Psychiatry. 2001;178:360–366
  3. Avila J. Tau phosphorylation and aggregation in Alzheimer's disease pathology. FEBS Lett. 2006;580(12):2922–2927
  4. Bedford PD. Adverse cerebral effects of anesthesia on old people. Lancet. 1955;ii:259–263
  5. Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron. 2005;45(5):675–688
  6. Binder LI, Guillozet-Bongaarts AL, Garcia-Sierra F, Berry RW. Tau, tangles, and Alzheimer's disease. Biochim. Biophys. Acta. 2005;1739(2–3):216–223
  7. Bohnen N, Warner MA, Kokmen E, Beard CM, Kurland LT. Alzheimer's disease and cumulative exposure to anesthesia: a case-control study. J. Am. Geriatr. Soc. 1994;42(2):198–201
  8. Carnini A., Lear, J.D., Eckenhoff, R.G., 2007. Inhaled anesthetic modulation of amyloid beta1-40 assembly and growth. Curr. Alzheimer Res., in press.
  9. Catalano SM, Dodson EC, Henze DA, Joyce JG, Krafft GA, Kinney GG. The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease. Curr. Top. Med. Chem. 2006;6(6):597–608
  10. Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, et al. Self-assembly of Abeta (1-42) into globular neurotoxins. Biochemistry. 2003;42(44):12749–12760
  11. Churcher I. Tau therapeutic strategies for the treatment of Alzheimer's disease. Curr. Top. Med. Chem. 2006;6(6):579–595
  12. Culley DJ, Baxter M, Yukhananov R, Crosby G. The memory effects of general anesthesia persist for weeks in young and aged rats. Anesth. Analg. 2003;96(4):1004–1009
  13. Culley DJ, Baxter MG, Crosby CA, Yukhananov R, Crosby G. Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats. Anesth. Analg. 2004;99(5):1393–1397
  14. Culley DJ, Baxter MG, Yukhananov R, Crosby G. Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats. Anesthesiology. 2004;100(2):309–314
  15. Davidsson P, Westman-Brinkmalm A, Nilsson CL, Lindbjer M, Paulson L, Andreasen N, et al. Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients. Neuroreport. 2002;13(5):611–615
  16. Eckenhoff RG. Promiscuous ligands and attractive cavities: How do the inhaled anesthetics work?. Mol. Interv. 2001;1:258–268
  17. Eckenhoff RG, Johansson JS. Molecular interactions between inhaled anesthetics and proteins. Pharmacol. Rev. 1997;49(4):343–367
  18. Eckenhoff RG, Johansson JS, Wei H, Carnini A, Kang B, Wei W, et al. Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity. Anesthesiology. 2004;101(3):703–709
  19. Gasparini M, Vanacore N, Schiaffini C, Brusa L, Panella M, Talarico G, et al. A case-control study on Alzheimer's disease and exposure to anesthesia. Neurol. Sci. 2002;23(1):11–14
  20. Ghirlanda G, Hilcove SA, Pidikiti R, Johansson JS, Lear JD, DeGrado WF, et al. Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide. FEBS Lett. 2004;578(1–2):140–144
  21. Gotz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 2001;293(5534):1491–1495
  22. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 1996;274(5284):99–102
  23. Jevtovic-Todorovic V, Hartman RE, Izumi Y, Benshoff ND, Dikranian K, Zorumski CF, et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J. Neurosci. 2003;23(3):876–882
  24. Johnson T, Monk T, Rasmussen LS, Abildstrom H, Houx P, Korttila K, et al. Postoperative cognitive dysfunction in middle-aged patients. Anesthesiology. 2002;96(6):1351–1357
  25. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003;300(5618):486–489
  26. Klein WL, Stine WB, Teplow DB. Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiol. Aging. 2004;25(5):569–580
  27. Kvolik S, Glavas-Obrovac L, Bares V, Karner I. Effects of inhalation anesthetics halothane, sevoflurane, and isoflurane on human cell lines. Life Sci. 2005;77(19):2369–2383
  28. Lee TA, Wolozin B, Weiss KB, Bednar MM. Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty. J. Alzheimers Dis. 2005;7(4):319–324
  29. Lee VM, Trojanowski JQ. Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now. J. Alzheimers Dis. 2006;9(3 Suppl.):257–262
  30. Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006;440(7082):352–357
  31. Liu R, Loll PJ, Eckenhoff RG. Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein. FASEB J. 2005;19(6):567–576
  32. Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar M, et al. Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro. Anesthesiology. 2005;102(6):1147–1157
  33. Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, et al. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet. 1998;351(9106):857–861(erratum appears in Lancet 1998 June 6;351(9117):1742)
  34. Muravchick S, Smith DS. Parkinsonian symptoms during emergence from general anesthesia. Anesthesiology. 1995;82(1):305–307
  35. Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, et al. Temporal profile of Abeta oligomerization in an in vivo model of Alzheimer's disease: a link between Abeta and tau pathology. J. Biol. Chem. 2006;281(3):1599–1604
  36. Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R. Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science. 2005;307(5707):262–265
  37. Selkoe DJ. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat. Cell Biol. 2004;6(11):1054–1061
  38. Wei H, Kang B, Wei W, Liang G, Meng QC, Li Y, et al. Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently. Brain Res. 2005;1037(1–2):139–147
  39. Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, et al. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J. Neurosci. 2002;22(5):1858–1867
  40. Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, et al. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology. 2006;104(5):988–994
  41. Xie Z, Tanzi RE. Alzheimer's disease and post-operative cognitive dysfunction. Exp. Gerontol. 2006;41(4):346–359
  42. Yon JH, Daniel-Johnson J, Carter LB, Jevtovic-Todorovic V. Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways. Neuroscience. 2005;135(3):815–827

PII: S0197-4580(07)00047-4

doi: 10.1016/j.neurobiolaging.2007.02.009

Neurobiology of Aging
Volume 29, Issue 7 , Pages 1002-1010 , July 2008