Neurobiology of Aging
Volume 29, Issue 5 , Pages 716-723 , May 2008

Glucocorticoid receptor variant and risk of dementia and white matter lesions

  • Elisabeth F.C. van Rossum

      Affiliations

    • Department of Internal Medicine, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • Department of Epidemiology & Biostatistics, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • These authors contributed equally.
    • ,
  • Frank Jan de Jong

      Affiliations

    • Department of Epidemiology & Biostatistics, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • Department of Neurology, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • These authors contributed equally.
    • ,
  • Jan W. Koper

      Affiliations

    • Department of Internal Medicine, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • ,
  • André G. Uitterlinden

      Affiliations

    • Department of Internal Medicine, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • ,
  • Niels D. Prins

      Affiliations

    • Department of Neurology, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • ,
  • Ewoud J. van Dijk

      Affiliations

    • Department of Neurology, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • ,
  • Peter J. Koudstaal

      Affiliations

    • Department of Neurology, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • ,
  • Albert Hofman

      Affiliations

    • Department of Epidemiology & Biostatistics, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • ,
  • Frank H. de Jong

      Affiliations

    • Department of Internal Medicine, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • ,
  • Steven W.J. Lamberts

      Affiliations

    • Department of Internal Medicine, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • ,
  • Monique M.B. Breteler

      Affiliations

    • Department of Epidemiology & Biostatistics, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 10 4087930; fax: +31 10 4089382.

Received 4 September 2006 ,Revised 13 November 2006 ,Accepted 19 November 2006.

References 

  1. American Psychiatry Association . Diagnostic and Statistical Manual of Mental Disorders. American Psychiatry Association; 1987;
  2. Baxter JD, Rousseau GG. Glucocorticoid hormone action: an overview. Monogr. Endocrinol. 1979;12:1–24
  3. Bjorntorp P, Rosmond R. Obesity and cortisol. Nutrition. 2000;16:924–936
  4. Bots ML, van Swieten JC, Breteler MM, de Jong PT, van Gijn J, Hofman A, et al. Cerebral white matter lesions and atherosclerosis in the Rotterdam Study. Lancet. 1993;341:1232–1237
  5. Breteler MM. Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol. Aging. 2000;21:153–160
  6. Copeland JR, Kelleher MJ, Kellett JM, Gourlay AJ, Gurland BJ, Fleiss JL, et al. A semi-structured clinical interview for the assessment of diagnosis and mental state in the elderly: the Geriatric Mental State Schedule. I. Development and reliability. Psychol. Med. 1976;6:439–449
  7. de Groot JC, de Leeuw FE, Oudkerk M, van Gijn J, Hofman A, Jolles J, et al. Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study. Ann. Neurol. 2000;47:145–151
  8. de Leeuw FE, De Groot JC, Oudkerk M, Witteman JC, Hofman A, van Gijn J, et al. Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly. Stroke. 2000;31:425–429
  9. den Heijer T, Geerlings MI, Hoebeek FE, Hofman A, Koudstaal PJ, Breteler MM. Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people. Arch. Gen. Psychiatr. 2006;63:57–62
  10. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 1975;12:189–198
  11. Hofman A, Grobbee DE, de Jong PT, van den Ouweland FA. Determinants of disease and disability in the elderly: the Rotterdam Elderly Study. Eur. J. Epidemiol. 1991;7:403–422
  12. Hofman A, Ott A, Breteler MM, Bots ML, Slooter AJ, van Harskamp F, et al. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet. 1997;349:151–154
  13. Huizenga NA, Koper JW, de Lange P, Pols HA, Stolk RP, Grobbee DE, et al. Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo–pituitary–adrenal axis to a low dose of dexamethasone in elderly individuals. J. Clin. Endocrinol. Metab. 1998;83:47–54
  14. Kalmijn S, Feskens EJ, Launer LJ, Stijnen T, Kromhout D. Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men. Diabetologia. 1995;38:1096–1102
  15. Kalmijn S, Launer LJ, Stolk RP, de Jong FH, Pols HA, Hofman A, et al. A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly. J. Clin. Endocrinol. Metab. 1998;83:3487–3492
  16. Kelly JJ, Mangos G, Williamson PM, Whitworth JA. Cortisol and hypertension. Clin. Exp. Pharmacol. Physiol. Suppl. 1998;25:S51–S56
  17. Koper JW, Stolk RP, de Lange P, Huizenga NA, Molijn GJ, Pols HA, et al. Lack of association between five alleles in the human glucocorticoid receptor gene and glucocorticoid resistance. Human Genet. 1997;99:663–668
  18. Lupien SJ, de Leon M, de Santi S, Convit A, Tarshish C, Nair NP, et al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat. Neurosci. 1998;1:69–73
  19. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939–944
  20. O’Brien JT, Schweitzer I, Ames D, Tuckwell V, Mastwyk M. Cortisol suppression by dexamethasone in the healthy elderly: effects of age, dexamethasone levels, and cognitive function. Biol. Psychiatr. 1994;36:389–394
  21. Ott A, Breteler MM, van Harskamp F, Claus JJ, van der Cammen TJ, Grobbee DE, et al. Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. BMJ. 1995;310:970–973
  22. Ott A, Breteler MM, van Harskamp F, Stijnen T, Hofman A. Incidence and risk of dementia. The Rotterdam Study. Am. J. Epidemiol. 1998;147:574–580
  23. Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM. Diabetes mellitus and the risk of dementia: the Rotterdam Study. Neurology. 1999;53:1937–1942
  24. Prins ND, van Straaten EC, van Dijk EJ, Simoni M, van Schijndel RA, Vrooman HA, et al. Measuring progression of cerebral white matter lesions on MRI: visual rating and volumetrics. Neurology. 2004;62:1533–1539
  25. Rasmuson S, Andrew R, Nasman B, Seckl JR, Walker BR, Olsson T. Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimer's disease. Biol. Psychiatr. 2001;49:547–552
  26. Reul JM, de Kloet ER. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology. 1985;117:2505–2511
  27. Reul JM, Gesing A, Droste S, Stec IS, Weber A, Bachmann C, et al. The brain mineralocorticoid receptor: greedy for ligand, mysterious in function. Eur. J. Pharmacol. 2000;405:235–249
  28. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology. 1993;43:250–260
  29. Roth M, Tym E, Mountjoy CQ, Huppert FA, Hendrie H, Verma S, et al. CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br. J. Psychiatr. 1986;149:698–709
  30. Russcher H, van Rossum EFC, de Jong FH, Brinkmann AO, Lamberts SWJ, Koper JW. Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK allele. Mol. Endocrinol. 2005;19:1687–1696
  31. Sapolsky RM, Uno H, Rebert CS, Finch CE. Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J. Neurosci. 1990;10:2897–2902
  32. Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann. Neurol. 2002;52:168–174
  33. Seeman TE, McEwen BS, Singer BH, Albert MS, Rowe JW. Increase in urinary cortisol excretion and memory declines: MacArthur studies of successful aging. J. Clin. Endocrinol. Metab. 1997;82:2458–2465
  34. Stolk RP, Lamberts SW, de Jong FH, Pols HA, Grobbee DE. Gender differences in the associations between cortisol and insulin in healthy subjects. J. Endocrinol. 1996;149:313–318
  35. Umegaki H, Ikari H, Nakahata H, Endo H, Suzuki Y, Ogawa O, et al. Plasma cortisol levels in elderly female subjects with Alzheimer's disease: a cross-sectional and longitudinal study. Brain Res. 2000;881:241–243
  36. van Dijk EJ, Prins ND, Vermeer SE, Vrooman HA, Hofman A, Koudstaal PJ, et al. C-reactive protein and cerebral small-vessel disease: the Rotterdam Scan Study. Circulation. 2005;112:900–905
  37. van Rossum EFC, Feelders RA, van den Beld AW, Uitterlinden AG, Janssen JA, Ester W, et al. Association of the ER22/23EK allele in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. Am. J. Med. 2004;117:158–162
  38. van Rossum EFC, Koper JW, Huizenga NA, Uitterlinden AG, Janssen JA, Brinkmann AO, et al. A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes. 2002;51:3128–3134
  39. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and the risk of dementia and cognitive decline. N. Engl. J. Med. 2003;348:1215–1222
  40. Wenham PR, Price WH, Blandell G. Apolipoprotein E genotyping by one-stage PCR. Lancet. 1991;337:1158–1159

PII: S0197-4580(06)00439-8

doi: 10.1016/j.neurobiolaging.2006.11.016

Neurobiology of Aging
Volume 29, Issue 5 , Pages 716-723 , May 2008

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