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Neurobiology of Aging
Volume 29, Issue 5
, Pages 739-752
, May 2008
α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia
References
- . Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 1995;270:27995–27998
- . Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects. Neurosci. Lett. 2000;287:65–67
- . Protein kinase B (Akt) regulation and function in T lymphocytes. Semin. Immunol. 2002;14:19–26
- . Alpha-synuclein cooperates with CSPα in preventing neurodegeneration. Cell. 2005;123:383–396
- . Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. Mol. Cell. Biol. 1993;13:4679–4690
- . Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle. Cell. Mol. Life Sci. 2001;58:580–595
- . Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis. J. Biol. Chem. 2003;278:52052–52060
- . Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition. J. Neuroinflam. 2005;2:14
- . A novel assay to monitor amyloidogenicity in solution using the fluorescent dye K114. J. Neurochem. 2003;86:1359–1368
- . Stabilization of α-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem. 1998;273:9443–9449
- . Isolation and characterization of adult microglial cells and oligodendrocytes derived from postmortem human brain tissue.. Brain Res. Protocols. 2000;5:85–94
- . The genetics of Parkinson's disease. Curr. Opin. Genet. Dev. 2000;10:292–298
- . A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J. Immunol. Meth. 1988;15:61–69
- . MAP kinases in the immune response. Ann. Rev. Immunol. 2002;20:55–72
- . Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments. FEBS Lett. 1998;440:71–75
- . Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. FASEB J. 2003;17:1945–1947
- . MAPKAP kinase 2 is activated by heat shock and TNF-alpha: in vivo phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade. J. Cell Biochem. 1995;57:321–330
- . Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif. J. Biol. Chem. 1995;270:27213–27221
- . In vivo phosphorylation and activation of ribosomal protein S6 kinases during Xenopus oocyte maturation. J. Biol. Chem. 1989;264:13711–13717
- . Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies. J. Neural Transm. 2001;108:1383–1396
- . Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase. J. Biol. Chem. 2000;275:11064–11070
- . Tau phosphorylation increases in symptomatic mice overexpressing A30P α-synuclein. Exp. Neurol. 2005;192:274–287
- . Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell. 1994;78:1039–1049
- . Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J. Biol. Chem. 2002;277:28706–28713
- . Genetics of Parkinson's disease. Curr. Opin. Neurol. 2005;18:363–369
- George, J.M., 2002. The synucleins. Genome Biol. 3:reviews3002.1-reviews.6.
- . A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. J. Biol. Chem. 2001;276:2380–2386
- . Mutant and wild type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro. J. Biol. Chem. 1999;274:7619–7622
- . Alpha-synuclein and neurodegenerative diseases. Nat. Rev. Neurosci. 2001;2:492–501
- . The E46K mutation in alpha-synuclein increases amyloid fibril formation. J. Biol. Chem. 2005;280:7800–7807
- . Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase. Biochemistry. 1993;32:7727–7738
- . Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Meth. 1989;119:203–210
- . α-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells. J. Biol. Chem. 2002;277:11465–11472
- . Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J. Neurochem. 2000;75:965–972
- . The state of the STATs: recent developments in the study of signal transduction to the nucleus. Curr. Opin. Cell Biol. 1997;9:233–239
- . Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis. Acta Pharmacol. Sin. 2005;26:1253–1258
- . Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using α-synuclein-immunohistochemistry. Neurosci. Lett. 2000;286:69–73
- . Microglial activation parallels system degeneration in multiple system atrophy. J. Neuropath. Exp. Neurol. 2004;63:43–52
- . The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron. 1995;14:467–475
- . α-Synuclein affects the MAPK pathway and accelerates cell death. J. Biol. Chem. 2001;276:45320–45329
- . 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. J. Biol. Chem. 1999;274:27168–27176
- . Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. J. Neurosci. 2005;25:3701–3711
- . The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 1996;15:7060–7069
- . Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid type CB2 receptor. Br. J. Pharmacol. 2003;139:775–786
- . Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in astrocytes and astrocytoma cells. FASEB J. 2006;20:2000–2008
- . Chymotrypsin-like proteases contribute to human monocytic THP-1 cell as well as human microglial neurotoxicity. Glia. 2005;51:56–64
- . Interaction of various intracellular signaling mechanisms involved in mononuclear phagocyte toxicity toward neuronal cells. J. Leukoc. Biol. 2000;67:127–133
- . Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J. Biol. Chem. 1996;271:8313–8320
- . Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 1998;18:106–108
- . Intravesicular localization and exocytosis of α-synuclein and its aggregates. J. Neurosci. 2005;25:6016–6024
- . A precipitating role for truncated α-synuclein and the proteasome in α-synuclein aggregation: implications for pathogenesis of Parkinson disease. J. Biol. Chem. 2005;280:22670–22678
- . β-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes. J. Neurosci. 1998;18:4451–4460
- . c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell Biol. 1994;14:6683–6688
- . Distinct cleavage patterns of normal and pathologic forms of α-synuclein by calpain I in vitro. J. Neurochem. 2003;86:836–847
- . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 1983;65:55–63
- . The role of the carboxy terminus of alpha-synuclein on fibril formation in vitro. Biochemistry. 2003;42:8530–8540
- . Localization of phosphoneuroprotein 14 (PNP 14) and its mRNA expression in rat brain determined by immunocytochemistry and in situ hybridization. Brain Res. Mol. Brain Res. 1994;27:81–86
- . Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem. J. 1999;344:427–431
- . Clinical heterogeneity of α-synuclein gene duplication in Parkinson's disease. Ann. Neurol. 2006;59:298–309
- . Alpha-synuclein: normal function and role in neurodegenerative diseases. Curr. Topics Dev. Biol. 2004;60:17–54
- . Kinetworks protein kinase multiblot analysis. Meth. Mol. Biol. 2003;218:99–111
- . Could a loss of alpha-synuclein function put dopaminergic neurons at risk?. J. Neurochem. 2004;89:1318–1324
- . Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 1997;276:2045–2047
- . α-Synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway. FASEB J. 2002;16:1826–1828
- . Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C. J. Biol. Chem. 1997;272:7586–7594
- . Dityrosine cross-linking promotes formation of stable α-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J. Biol. Chem. 2000;275:18344–18349
- . Oxidative stress in transgenic mice with oligodendroglial α-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy. Am. J. Pathol. 2005;166:869–876
- . Proteolytic cleavage of extracellular secreted α-synuclein via matrix metalloproteinases. J. Biol. Chem. 2005;280:25216–25224
- . Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem. J. 1993;296:15–19
- . Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts. Biochem. Biophys. Res. Commun. 2004;316:411–415
- . Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing. FEBS Lett. 2006;580:399–409
- . Identification of serine 380 as the major site of autophosphorylation of Xenopus pp90rsk. Biochem. Biophys. Res. Commun. 1997;235:398–402
- . NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry. 1996;35:13709–13715
- . Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1. J. Biol. Chem. 2000;275:40400–40406
- . Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol. Cell Biol. 1998;18:1946–1955
- . The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. J. Biol. Chem. 1999;274:34029–34035
- . The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 2004;55:164–173
- . B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1. J. Biol. Chem. 2004;279:35726–35734
- . Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J. Biol. Chem. 2002;277:43648–43658
- . α-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005;19:533–542
- . Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. EMBO J. 1994;13:1123–1131
- . Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Brain Pathol. 2003;13:473–481
- . Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases. Am. J. Pathol. 2002;161:2087–2098
PII: S0197-4580(06)00436-2
doi: 10.1016/j.neurobiolaging.2006.11.013
© 2006 Elsevier Inc. All rights reserved.
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Neurobiology of Aging
Volume 29, Issue 5
, Pages 739-752
, May 2008
